CAS: 956100-62-2; 8-Bromo-2-Chloroquinazolin-4-Amine
该化合物是一种卤化的五氯苯衍生物,在制药和化学研究方面有很大的效用,其独特的结构,以五氯基的溴和氯替代物为主,增强了其反应性,使其成为生物活性化合物合成中的宝贵中间体.溴和氯组的存在允许有选择的功能化,有利于在药用化学应用中进一步衍生.这种化合物对于针对环环球食肉类的动脉抑制剂和其他治疗剂的发展特别有用.在标准条件下,它的高纯度和稳定性确保了合成工作流程的可靠性能.研究人员认为这种化合物在建造复杂的分子结构中具有多功能性.
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号331647-05-3 8-溴-2,4-二氯喹唑啉 | CAS号956100-63-3 8-溴-2-氯喹唑啉合成工艺路线路线简述
- 合成目标产物 4-Amino-8-Bromo-2-Chloroquinazoline 主要起始原料 8-Bromo-2,4-Dichloroquinazoline
- 331647-05-3 = 956100-62-2
反应条件:1.1 Reagents: Ammonia Solvents: Methanol,Dichloromethane; 16 H,Rt
标题:Condensed-Ring Pyrimidylamino Derivatives,Preparation Method Therefor,And Intermediate,Pharmaceutical Composition And Applications In The Treatment Of Cancer
参考文献:World Intellectual Property Organization]
57-13-6 + 20776-51-6 = 956100-62-2
反应条件:1.1 Heated; 16 H,150 °C1.2 Reagents: Phosphorus Oxychloride Catalysts: N,N-Dimethylaniline; Rt; 16 H,120 °C; 120 °C -> Rt1.3 Reagents: Ammonia Solvents: Tetrahydrofuran,Water; 2 H,Rt
标题:Beta-Adrenergic Receptor Allosteric Modulators
参考文献:World Intellectual Property Organization]
= 956100-62-2 [标题:Reaction Conditions
标题:An Allosteric Modulator Binds To A Conformational Hub In The β2 Adrenergic Receptor
作者:Liu,Xiangyu; Kaindl,Jonas; Korczynska,Magdalena; Stossel,Anne; Dengler,Daniela; Et Al
参考文献:Nature Chemical Biology 日期:2020 卷标:16(7) 页码:749-755]
331647-05-3 = 956100-62-2
反应条件:1.1 Reagents: Ammonia Solvents: Methanol,Dichloromethane; 16 H,Rt
标题:Fused Ring Pyrimidine Compound,Intermediate,And Preparation Method,Composition And Use Thereof
参考文献:World Intellectual Property Organization]
331647-05-3 = 956100-62-2
反应条件:1.1 Reagents: Ammonia Solvents: Dichloromethane; Overnight,Rt
标题:Substituted 2-Amino-Fused Heterocyclic Compounds As Jnk Modulators And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Diabetes And Related Diseases
参考文献:World Intellectual Property Organization]
331647-05-3 = 956100-62-2
反应条件:1.1 Reagents: Ammonium Hydroxide Solvents: Tetrahydrofuran; 30 Min,0 °C
标题:Certain Chemical Entities,Compositions,And Methods
参考文献:World Intellectual Property Organization]
331647-05-3 = 956100-62-2
反应条件:1.1 Reagents: Ammonium Hydroxide Solvents: Tetrahydrofuran; 30 Min,0 °C
标题:Preparation Of Quinazoline And Pyrido[3,4-D]Pyrimidine Derivatives As Protein Kinase Inhibitors For Treatment Of Cancer
参考文献:World Intellectual Property Organization]
331647-05-3 = 956100-62-2
反应条件:1.1 Reagents: Ammonium Hydroxide Solvents: Tetrahydrofuran,Water; 0 °C; Overnight,Rt; 1 H,Rt
标题:Preparation Of Fused Pyridinones And Related Compounds As Pim Kinase Inhibitors And Their Use In The Treatment Of Cancer
参考文献:World Intellectual Property Organization
📜2-氨基-3-溴苯甲酸置于ammonium Hydroxide,三氯氧磷体系中,用 四氢呋喃,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 15.5H,反应生成 4-氨基-8-溴-2-氯喹唑啉
参考文献: Certain Chemical Entities,Compositions,And Methods[fr] Entités Chimiques,Compositions Et Méthodes Particulières
标题: Certain Chemical Entities,Compositions,And Methods[fr] Entités Chimiques,Compositions Et Méthodes Particulières
摘要:描述了作为激酶抑制剂的化学实体,药物组合物以及治疗癌症的方法.
