CAS: 924-73-2; Ethyl 3-Aminopropanoate

该化合物是β-拉尼的酯衍生物,具有氨基氨基和酯功能组,该化合物是有机合成的多种中间体,特别是在制药,农用化学品和特殊化学品的制作方面,其双功能再活动允许选择性修改,使其在浸泡物结合和热循环形成中具有价值;乙酯组增加有机溶剂的溶性,便利在温和条件下作出反应;乙基-3氨基丙诺酸具有明确界定的结构和高纯度,在合成应用中具有一贯性能;在标准储存条件下,其稳定性进一步确保了研究和工业过程中的可靠使用.

结构式图片

相似化合物

4244-84-2 23583-21-3 88574-53-2

物理性质

MSDS等安全信息

上下游产品

N-formyl-β-alanine ethyl esterN-formyl-β-alanine ethyl ester ethanol β-alanine hydr°Chloride ethyl 2-cyanoacetate 2-azetidinone aminTris2-(ethoxycarbonyl)ethylamin 3,3'-imino-di-propionic acid diethyl ester N-(N-benzyloxycarbonyl-glycyl)-β-alanine ethyl esterN-(N-benzyloxycarbonyl-glycyl)-β-alanine ethyl ester

合成工艺路线路线简述

  • 107-95-9 = 924-73-2
    反应条件:1.1 Solvents: 2,2-Dimethoxypropane
    标题:Studies On The Synthesis Of Yohimbane And Campthoteca Alkaloids Through The Domino Knoevenagel-Hetero-Diels-Alder Reaction
    作者:Klapa,Katharina Anna
    参考文献:2007]

    107-95-9 = 924-73-2
    反应条件:1.1 Reagents: Thionyl Chloride Solvents: Ethanol; 4 H,Cooled1.2 8 H,60 °C
    标题:Process For The Preparation Of Resveratrol Amino Acid Ester Derivatives
    参考文献:China]

    40139-55-7 = 924-73-2
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol,Tetrahydrofuran; 6 H,Rt
    标题:Preparation Of 2-Fluoro-2-Deoxy-Glucose Conjugates For Improved Cancer Treatment
    参考文献:World Intellectual Property Organization]

    4244-84-2 = 924-73-2
    反应条件:1.1 Reagents: Ammonia Solvents: Water; 2 H,Rt
    标题:Favipiravir-Based Ionic Liquids As Potent Antiviral Drugs For Oral Delivery: Synthesis,Solubility,And Pharmacokinetic Evaluation
    作者:Moshikur,Rahman Md; Ali,Korban Md.; Wakabayashi,Rie; Moniruzzaman,Muhammad; Goto,Masahiro
    参考文献:Molecular Pharmaceutics 日期:2021 卷标:18(8) 页码:3108-3115]

    107-95-9 = 924-73-2
    反应条件:1.1 Reagents: Thionyl Chloride; Rt
    标题:Design,Synthesis,And Bioactivity Evaluation Of Novel Bcl-2/hdac Dual-Target Inhibitors For The Treatment Of Multiple Myeloma
    作者:Zhou,Ruolan; Fang,Shaoyu; Zhang,Minmin; Zhang,Qingsen; Hu,Jian; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2019 卷标:29(3) 页码:349-352]

    107-95-9 = 924-73-2
    反应条件:1.1 Reagents: Thionyl Chloride Solvents: Ethanol; -10 °C; 2 H,80 °C; 80 °C -> Rt1.2 Solvents: Tert-Butyl Methyl Ether; 20 Min,Rt
    标题:Preparation Of The Tri-Cycle Compound And Their Medical Applications In The Treatment Of Hbv Related Diseases
    参考文献:World Intellectual Property Organization]

    4244-84-2 = 924-73-2
    反应条件:1.1 Reagents: Triethylamine
    标题:A Promising Cellulose-Based Polyzwitterion With Ph-Sensitive Charges
    作者:Elschner,Thomas; Heinze,Thomas
    参考文献:Beilstein Journal Of Organic Chemistry 日期:2014 卷标:10 页码:1549-1556]

    107-95-9 = 924-73-2
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethanol; 24 H,Reflux
    标题:Synthesis,Characterization And Pharmacological Evaluation Of Amide Prodrugs Of Flurbiprofen
    作者:Mishra,Ashutosh; Veerasamy,Ravichandran; Jain,Prateek Kumar; Dixit,Vinod Kumar; Agrawal,Ram Kishor
    参考文献:Journal Of The Brazilian Chemical Society 日期:2008 卷标:19(1) 页码:89-100]

    31295-20-2 = 924-73-2
    反应条件:1.1 Reagents: Hydrochloric Acid,Thionyl Chloride Catalysts: Ethanol
    标题:Thiocarbonyl Olefination. Iv. Preparation Of β-Amino Acids From N-(Acetyl)Thio Amides; Total Synthesis Of Iturinic Acid
    作者:Slopianka,Marion; Gossauer,Albert
    参考文献:Liebigs Annalen Der Chemie 日期:1981 卷标:(12) 页码:2258-65]

    = 924-73-2 [标题:Reaction Conditions
    标题:Pharmaceutical Compositions Containing Conjugates Of 2-Fluoro-2-Deoxy-Glucose With Anticancer Agents For Improved Cancer Treatment
    参考文献:European Patent Organization]

    107-95-9 = 924-73-2
    反应条件:1.1 Reagents: Thionyl Chloride Solvents: Ethanol; 0 °C; Overnight,Reflux1.2 Reagents: Potassium Hydroxide Solvents: Dichloromethane,Water; 0 °C
    标题:Polymerisation Of β-Alanine Through Catalytic Ester-Amide Exchange
    作者:Steunenberg,Peter; Koenst,Paul M.; Scott,Elinor L.; Franssen,Maurice C. R.; Zuilhof,Han; Et Al
    参考文献:European Polymer Journal 日期:2013 卷标:49(7) 页码:1773-1781]

    = 924-73-2
    反应条件:1.1 Catalysts: Cesium Fluoride Solvents: Water; 35 Min
    标题:Cesium Fluoride-Catalyzed Aza-Michael Addition Reaction In Aqueous Media
    作者:Labade,Vilas B.; Pawar,Shivaji S.; Shingare,Murlidhar S.
    参考文献:Monatshefte Fuer Chemie 日期:2011 卷标:142(10) 页码:1055-1059]

    40139-55-7 = 924-73-2
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol,Dichloromethane; 7 H,Rt
    标题:Synthesis And Cytotoxic Properties Of New Fluorodeoxyglucose-Coupled Chlorambucil Derivatives
    作者:Reux,Bastien; Weber,Valerie; Galmier,Marie-Josephe; Borel,Michele; Madesclaire,Michel; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2008 卷标:16(9) 页码:5004-5020]

    105-56-6 = 924-73-2
    反应条件:1.1 Reagents: Iron Chloride (Fecl3),Sodium Borohydride Solvents: Ethanol
    标题:Reduction Of Nitriles With Combined Reducing Agent - Sodium Borohydride/iron Salts
    作者:Lin,Ronghui; Zhang,Yongmin; Zhou,Zhiniu
    参考文献:Gaodeng Xuexiao Huaxue Xuebao 日期:1990 卷标:11(8) 页码:889-90]

    107-95-9 = 924-73-2
    反应条件:1.1 Reagents: Hydrochloric Acid,Ammonia Solvents: Chloroform
    标题:The Total Syntheses Of Dl-Matrine And Dl-Leontine
    作者:Mandell,Leon; Singh,K. P.; Gresham,J. T.; Freeman,W. J.
    参考文献:Journal Of The American Chemical Society 日期:1965 卷标:87(22) 页码:5234-6]

    4244-84-2 = 924-73-2
    反应条件:1.1 Reagents: Ammonia Solvents: Diethyl Ether,Water; 2 H,Rt
    标题:Ionic Liquid,Solvent,And Transdermal Preparation
    参考文献:Japan]

    107-95-9 = 924-73-2
    反应条件:1.1 Reagents: Thionyl Chloride Solvents: Ethanol; -5 °C; 3 H,Rt
    标题:Synthesis Of Ergosterol Peroxide Conjugates As Mitochondria Targeting Probes For Enhanced Anticancer Activity
    作者:Bu,Ming; Li,Hongling; Wang,Haijun; Wang,Jing; Lin,Yu; Et Al
    参考文献:Molecules 日期:2019 卷标:24(18)]

    107-95-9 = 924-73-2
    反应条件:1.1 Reagents: Thionyl Chloride Solvents: Ethanol; 0 °C; Overnight,Reflux1.2 Reagents: Potassium Hydroxide Solvents: Dichloromethane; Cooled
    标题:Enzyme-Catalyzed Polymerization Of β-Alanine Esters,A Sustainable Route Towards The Formation Of Poly-β-Alanine
    作者:Steunenberg,Peter; Uiterweerd,Michiel; Sijm,Maarten; Scott,Elinor L.; Zuilhof,Han; Et Al
    参考文献:Current Organic Chemistry 日期:2013 卷标:17(7) 页码:682-690]

    = 924-73-2
    反应条件:1.1 Reagents: Monochloramine Solvents: Ethanol; 15 Min,< 10 °C; Rt
    标题:Synthesis Of Substituted Aziridines Via Intramolecular Reactions Of β-N-Chloroethylamino Carbanions
    作者:Makosza,Mieczyslaw; Bobryk,Karolina; Krajewski,Dariusz
    参考文献:Heterocycles 日期:2008 卷标:76(2) 页码:1511-1524]

    = 924-73-2 [标题:Reaction Conditions
    标题:A New Glycociamidine Ring Precursor: Syntheses Of (Z)-Hymenialdisine,(Z)-2-Debromohymenialdisine,And (+/-)-Endo-2-Debromohymenialdisine
    作者:Papeo,Gianluca; Posteri,Helena; Borghi,Daniela; Varasi,Mario
    参考文献:Organic Letters 日期:2005 卷标:7(25) 页码:5641-5644
📜Beta-丙氨酸乙酯盐酸盐置于ammonium Hydroxide体系中,化学反应生成 3-氨基丙酸乙酯
参考文献:杂合磺基膦肽的首次合成和合成
标题:杂合磺基膦肽的首次合成和合成
摘要:首先,通过n-保护的2-氨基链烷磺酰胺,芳族醛和芳基二氯膦的曼尼希型反应,然后用氨基酯进行氨解,以令人满意的高收率合成杂合的磺化膦肽肽.
DOI:10.1021/ol901543Y

海关参考信息

专利信息


专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:US-5405949-A
优先权日:1993-03-29
标题 :Process for the synthesis of glycosaminoglycans with heparin or heparan structure modified in position 2 of the α-L-iduronic-2-O-sulfate acid
发明人：UNGARELLI FABRIZIO; PIANI SILVANO
权利人:ALFA WASSERMANN SPA
摘要:A process for the synthesis of glycosaminoglycans with heparin or heparan structure modified in position 2 of the α-L-iduronic-2-O-sulfate acid in which the sulfate group is, entirely or in part, substituted with a nucleophilic group, is described. The process is carried out by treating glycosaminoglycans having heparin or heparan structure with a nucleophilic reagent in alkaline solution.

专利号:US-5410039-A
优先权日:1993-03-29
标题 :Process for the synthesis of glycosaminoglycans containing α-L-galacturonic acid substituted with nucleophilic groups in position 3
发明人：UNGARELLI FABRIZIO; PIANI SILVANO
权利人:ALFA WASSERMANN SPA
摘要:A process for the synthesis of glycosaminoglycans in which one of the α-L-iduronic-2-O-sulfate acid saccharide units, which is characteristic of glycosaminoglycans with heparin or heparan structure, has undergone a structural modification, entirely or in part, with transformation into α-L-galacturonic acid substituted in position 3 with nucleophilic groups, is described. The process is carried out by treating glycosaminoglycans having heparin or heparan structure with a nucleophilic reagent in alkaline solution.

专利号:US-8710220-B2
优先权日:2009-12-10
标题 :Synthesis of 8-amino boron dipyrromethenes having blue fluorescence
发明人：PE A CABRERA EDUARDO; AZAEL CÉSAR FERNANDO; FLORES JUAN ORLANDO
权利人:PE A CABRERA EDUARDO; AZAEL CÉSAR FERNANDO; FLORES JUAN ORLANDO; UNIV GUANAJUATO
摘要:A family of six 8-amino boron dipyrromethenes having Formulas 1, 2, 3, 4, 6, and 7 has been prepared. The presence of the amine group alters the emission properties of the boron dipyrromethene, such that these compounds are characterized by unexpected blue fluorescence, providing for potential use as lasers. The compound having formula 1 has very high quantum yield. The 8-amino boron dipyrromethenes are prepared in a straightforward, high yield synthesis by substituting an amine group for the thiomethyl group at the 8 position in 8-thiomethyl boron dipyrromethene. The compounds having Formulas 6 and 7 may be used to incorporate peptides and proteins, thus providing biomolecules marked with fluorescent fragments.

专利号:US-9365544-B2
优先权日:2012-07-16
标题 :Process for the preparation of intermediates for the synthesis of Dabigatran Etexilate, and crystalline forms of said intermediates
发明人：HERNÀNDEZ GALLEGO SANTOS; MARQUILLAS OLONDRIZ FRANCISCO; POMARES MARCO MARTA
权利人:INTERQUIM SA
摘要:The present invention relates to new processes for the preparation of synthesis intermediate products useful in the preparation of Dabigatran Etexilate on an industrial scale. The invention also relates to new crystalline forms of intermediate products thus obtained.

专利号:US-6177087-B1
优先权日:1994-06-24
标 题:Non-antigenic amine derived polymers and polymer conjugates
发明人：GREENWALD RICHARD B; MARTINEZ ANTHONY; PENDRI ANNAPURNA
权利人:ENZON INC
摘要:Substantially non-antigenic polymers containing pI and/or pH optimum modulating moieties are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleophiles. Conjugates and methods of preparation and treatment with the conjugates are also disclosed.

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合成参考文献


摘要:Ye, Z.-S., Science of Synthesis Knowledge Updates, (2021) 2, 335.
摘要:Okumura, M., Science of Synthesis: Dearomatizations, (2026) .
参考文献:10.1107/s1600536810028849
摘要:He YJ, Zou P, Wang HY, Wu H, Xie MH. Glycine ethyl ester hydro-chloride. Acta Crystallogr Sect E Struct Rep Online. 2010 Jul 24;66(Pt 8):o2115.
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