CAS: 875446-37-0; (4S,5R)-5-(3,5-Bis(Trifluoromethyl)Phenyl)-3-((4'-Fluoro-5'-Isopropyl-2'-Methoxy-4-(Trifluoromethyl)-[1,1'-Biphenyl]-2-yl)Methyl)-4-Methyloxazolidin-2-One

上下游产品

CAS号875446-35-8 (4S,5R)-5-[3,5-... | CAS号875446-29-0 4-氟-5-异丙基-2-甲氧基苯基硼酸 | CAS号74457-86-6 2-氟-4-甲氧基苯乙酮 | CAS号96826-25-4 2-(2-fluoro-4-m... | CAS号944317-92-4 4-氟-1-溴-2-甲氧基-5-异丙基苯 | CAS号348-57-2 2,4-二氟溴苯 | CAS号450-88-4 2-溴-5-氟苯甲醚 | CAS号914221-54-8 1-(5-溴-2-氟-4-甲氧... | CAS号958029-46-4 Benzenemethanol...

Benzyl N-[1-[3,5-Bis(Trifluoromethyl)Phenyl]-1-Hydroxypropan-2-Yl]-N-[[2-(4-Fluoro-2-Methoxy-5-Propan-2-Ylphenyl)-5-(Trifluoromethyl)Phenyl]Methyl]Carbamate置于potassium Hydroxide体系中,用 四氢呋喃,甲醇 作为反应溶剂,以89%的收率获得产物安塞曲匹
参考文献:安塞曲匹的制备方法
标题:安塞曲匹的制备方法
摘要:本发明提供一种安塞曲匹的制备方法,首先使用化合物1通过叶立德反应得到烯烃后环氧化得到化合物2;然后,采用化合物2和化合物3在溶剂中进行反应制备化合物4,最后通过化合物4与发生缩合反应制备得到化合物5,化合物5经过脱保护环化得到化合物6安塞曲匹:本发明提供的操作方法简单,对反应体系中水分要求不高,工艺成本低,适合工业应用.

专利信息

专利号:WO-2013091696-A1
优先权日:2011-12-21
标题 :Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:LEK PHARMACEUTICALS; HUMLJAN JAN; MARAS NENAD
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:EP-2468735-A1
优先权日:2010-12-23
标 题:Synthesis of intermediates for preparing anacetrapib and derivates thereof
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:US-9212118-B2
优先权日:2010-12-23
标题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:HUMLJAN JAN; MARAS NENAD; LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-10865163-B2
优先权日:2017-12-20
标题:Carbon dioxide as a directing group for C—H functionalization reactions involving Lewis basic amines, alcohols, thiols, and phosphines for the synthesis of compounds
发明人：YOUNG MICHAEL C; KAPOOR MOHIT
权利人:UNIV TOLEDO
摘要:Methods of synthesizing compounds using CO 2 as a directing group for C—H functionalization, and compounds made thereby, are described.

专利号:US-10300471-B2
优先权日:2013-10-08
标题 :Ruthenium-catalyzed synthesis of biaryl compounds in water
发明人：KOOHANG ALI AIDEN; MEHTA ANITA
权利人:CHICAGO DISCOVERY SOLUTIONS LLC
摘要:Using a [RuCl 2 (arene)] 2 complex and a formate source, a directed ortho C—H insertion and aryl-aryl coupling sequence in water provides biaryl compounds useful in the preparation of biologically active molecules and intermediates. Reactions may be conducted in the ambient atmosphere. Ruthenium catalysts prepared from [RuCl 2 (arene)] 2 and a formate source may be prepared in situ or isolated for later use.