CAS: 68497-62-1; N-(2-(Diisopropylamino)Ethyl)-2-(2-Oxopyrrolidin-1-yl)Acetamide

上下游产品

2-(oxo-pyrrolidin-1-yl)-acetic acid ethyl ester N',N'-diisopropyl-ethane-1,2-diamine 2-pyrrolidinonPramiracetam sulfate

N,N-二异丙基乙二胺置于sodium Methylate体系中,用 四氢呋喃,甲苯 作为反应溶剂,化学反应 4.67H,反应生成 普拉西坦
参考文献:一种硫酸普拉西坦的工业化制备方法
标题:一种硫酸普拉西坦的工业化制备方法
摘要:本发明涉及化合物的制备领域,具体涉及一种硫酸普拉西坦的工业化制备方法.该方法包括:(1)将n‑(2‑(二异丙基)乙基)‑2‑氯乙酰胺盐酸盐转化得到游离酰胺,并去除所述游离酰胺中的水分;(2)在氮气保护下将固体碱与α‑吡咯烷酮在溶剂i中反应,同时蒸馏反应产生的醇,而后滴加所述游离酰胺与所述溶剂i制得的溶液,反应得到普拉西坦;(3)使用所述普拉西坦与硫酸制得硫酸普拉西坦.通过该方法可以高效率的得到质量非常好的硫酸普拉西坦,而且成本低廉,环境友好度高,未使用危险物料,工艺安全性高,有利于在工业化制备中推广应用.

专利信息

专利号:US-8063062-B2
优先权日:2006-12-20
标 题 :Compounds with a combination of cannabinoid-CB1 antagonism and acetylcholinesterase inhibition
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G; SHADID BELAL
权利人:LANGE JOSEPHUS H M; KRUSE CORNELIS G; SHADID BELAL; SOLVAY PHARM BV
摘要:Embodiments of this invention relate to compounds having a combination of cannabinoid-CB 1 antagonism and cholinesterase inhibition, to pharmaceutical compositions comprising these compounds, to methods for preparing these compounds, methods for preparing novel intermediates useful for the synthesis of these compounds, and methods for preparing compositions comprising these compounds. The invention also relates to methods of treating Alzheimer's disease, cognitive disorders, memory disorders, dementia, attention deficit disorder, traumatic brain injury, drug dependence, addiction or substance abuse by administering a pharmaceutical composition comprising these compounds to a patient in need thereof. A compound with a combination of cannabinoid-CB 1 antagonism and cholinesterase inhibition is a compound of formula (1) n nwherein the symbols have the meanings given in the specification.

专利号:US-2009176740-A1
优先权日:2007-11-30
标题:Treatment of neurological conditions by the co-administration of aniracetam and l-alpha glycerylphosphorylcholine
发明人：PHILLIPS II DAUGLAS JAMES
权利人:PHILLIPS II DAUGLAS JAMES
摘要:Aniracetam (1-[(4-methoxybenzoyl)]-2-pyrrolidinone) is co-administered with the acetylcholine precursor 1-alpha glycerylphosphorylcholine (Alpha GPC, choline alfoscerate, choline alphoscerate) to potentiate cognition enhancing effects in healthy subjects and patients suffering from neurological conditions including Alzheimer's Disease (AD), attention deficit disorder (ADD), Parkinson's Disease, schizophrenia, vascular dementia, post stroke aphasia, anxiety disorders, cerebral atrophy, chronic alcoholism, Down syndrome, dyslexia, and various other neurodegenerative conditions. The co-administration of aniracetam (and other racetam derivatives including oxiracetam) with the acetylcholine precursor 1-alpha glycerylphosphorylcholine decreases negative side-effects such as severe headaches while increasing the synthesis and release of the neurotransmitters acetylcholine and glutamate to facilitate proper brain functioning.

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-9550795-B2
优先权日:2011-08-31
标 题:Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
发明人：BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; HELAL CHRISTOPHER JOHN; O'NEILL BRIAN THOMAS
权利人:BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; HELAL CHRISTOPHER JOHN; O'NEILL BRIAN THOMAS; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:WO-2012172449-A1
优先权日:2011-06-13
标题:Lactams as beta secretase inhibitors
发明人：BRODNEY MICHAEL AARON
权利人:PFIZER; BRODNEY MICHAEL AARON
摘要:Compound and pharmaceutically acceptable salts of the compound are disclosed, wherein the compound has the structure (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. The compound of formula I is useful as beta secretase inhibitor for use in the treatment of Alzheimer's and other neurodegenerative and/or neurological disorders.

专利号:US-2016229847-A1
优先权日:2013-10-04
标 题:Novel bicyclic pyridinones as gamma-secretase modulators
发明人：PETTERSSON MARTIN YOUNGJIN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; JOHNSON DOUGLAS SCOTT; KAUFFMAN GREGORY WAYNE; O'DONNELL CHRISTOPHER WILLIAM; PATEL NANDINI CHATURBHAI; STEPAN ANTONIA FRIEDERIKE; STIFF CORY MICHAEL; SUBRAMANYAM CHAKRAPANI; TRAN TUAN PHONG; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula II as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.