CAS: 619-56-7; 4-Chlorobenzamide

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CAS号104-88-1 对氯苯甲醛 | CAS号637-87-6 对氯碘苯 | CAS号201230-82-2 carbon monoxide | CAS号3848-36-0 4-氯苯甲醛肟 | CAS号623-03-0 对氯苯腈 | CAS号122-01-0 4-氯苯甲酰氯 | CAS号1126-46-1 甲基-4-氯苯甲酸甲酯 | CAS号99-91-2 对氯苯乙酮 | CAS号21368-28-5 4-chlorobenzoyl... | CAS号1641-36-7 丁基铵乙酸盐 | CAS号3815-20-1 4-联苯基甲酰胺 | CAS号55-21-0 苯甲酰胺 | CAS号1455-99-8 Benzamide,N-but... | CAS号4018-82-0 4-氯-N-(4-甲氧基苯基)苯甲酰胺 | CAS号42365-43-5 4-氯苄胺盐酸盐 | CAS号22091-36-7 4-氯甲基-2-(4-氯苯基)... | CAS号1889-78-7 2-溴-1-(4-氯苯基)-2-苯基乙酮 | CAS号22087-22-5 [2-(4-氯苯基)噁唑-4-基]甲醇 | CAS号623-03-0 对氯苯腈 | CAS号104-86-9 4-氯苄胺

📜对氯扁桃酸置于copper(I) Oxide,Ammonium Hydroxide,氧气体系中,用 水 作为反应溶剂,化学反应 24.0H,以60%的收率获得产物4-氯苯甲酰胺
参考文献:Synthesis Of Primary Amides Via Copper-Catalyzed Aerobic Decarboxylative Ammoxidation Of Phenylacetic Acids And α-Hydroxyphenylacetic Acids With Ammonia In Water
标题:Synthesis Of Primary Amides Via Copper-Catalyzed Aerobic Decarboxylative Ammoxidation Of Phenylacetic Acids And α-Hydroxyphenylacetic Acids With Ammonia In Water
摘要:A Cu2O-Catalyzed Aerobic Oxidative Decarboxylative Ammoxidation To Primary Benzamides From Phenylacetic Acids And Alpha-Hydroxyphenylacetic Acids Is Developed. A Variety Of Primary Benzamides Could Be Prepared Smoothly,In Good To Excellent Yields,By Means Of A One-Pot Domino Protocol Combining Decarboxylation,Dioxygen Activation,Oxidative C-H Bond Functionalization,And Amidation Reactions.
DOI:10.1021/ol403586C

专利信息

专利号:US-4161609-A
优先权日:1977-09-14
标题:Synthesis of carboxylic acid esters
发明人：CRAMER RICHARD D
权利人:DU PONT
摘要:A method is provided for converting a carboxylic acid amide to a carboxylic acid ester by reacting a vaporized mixture of the amide and an aliphatic alcohol or a phenol in the presence of a suitable catalyst at temperatures of from 100 DEG C. to 400 DEG C. The process is especially useful for the conversion of methacrylamide to methyl methacrylate.

专利号:US-5817827-A
优先权日:1995-11-21
标题:Method for the dehydration of amides to nitriles
发明人：BONRATH WERNER; PAULING HORST
权利人:HOFFMANN LA ROCHE
摘要:The present invention relates to a process for the dehydration of amides to nitrites which comprises carrying out the dehydration in the presence of an adduct of sulphur trioxide and an amine as the dehydrating reagent in a basic reaction mixture. Thereby, for example, aliphatic, aromatic and heteroaromatic amides are dehydrated to the corresponding nitrites, such as 5-carbamoyl-4-methyl-oxazole to 5-cyano-4-methyl-oxazole, a valuable intermediate in the synthesis of pyridoxine.

专利号:US-5693792-A
优先权日:1992-02-18
标 题 :β-lactam and cephem compounds and processes for their production
发明人：TORII SHIGERU; TANAKA HIDEO; SASAOKA MITIO; SHIROI TAKASHI; KAMEYAMA YUTAKA
权利人:OTSUKA KAGAKU KK
摘要:The object of the invention is to provide a β-lactam compound and a 2-substituted methyl-3-cephem compound, both of which are of value as intermediates for the synthesis of cephem antibiotics. n The β-lactam compound of the invention may be represented by the general formula ##STR1## wherein R 1 represents a protected amino group, for instance; R 2 represents hydrogen, for instance; R 3 represents hydrogen or a carboxy-protecting group; R 4 represents an aryl group which may be substituted; R 5 represents an alkenyl group which may be substituted, for instance. The 2-substituted methyl-3-cephem compound of the invention may be represented by the general formula ##STR2## wherein R 1 , R 2 and R 3 are as defined above; R 6 represents an aryl group which may be substituted.

专利号:US-2007275962-A1
优先权日:2003-09-10
标 题:Heterobicyclic Compounds as Pharmaceutically Active Agents
发明人：KOUL ANIL; KLEBL BERT; MULLER GERHARD; MISSIO ANDREA; SCHWAB WILFRIED; HAFENBRADL DORIS; NEUMANN LARS; SOMMER MARC-NICOLA; MULLER STEFAN; HOPPE EDMUND; FREISLEBEN ACHIM; BACKES ALEXANDER; HARTUNG CHRISTIAN; FELBER BEATRICE; ZECH BIRGIT; ENGKVIST OLA; KERI GYORGY; ORFI LASZLO; BANHEGYI PETER; GREFF ZOLTAN; HORVATH ZOLTAN; VARGA ZOLTAN; MARKO PETER; PATO JANOS; SZABADKAI ISTVAN; SZEKELYHID ZSOLT; WACZEK FRIGYES
权利人:GPC BIOTECH AG
摘要:Described are heterobicyclic compounds such as 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]thiopyran 3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid amides, or benzo[b]thiophene-3-carboxylic acid amides and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of various diseases such as infectious diseases, including mycobacteriainduced infections and opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as compositions containing at least one heterobicyclic compound and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the heterobicyclic compound are disclosed.

专利号:CN-1634908-A
优先权日:2004-10-21
标题:Process for synthesis of (3R,5R)-3-hydroxy-5-amino ethyl cyclo-valerolactone

专利号:US-4925869-A
优先权日:1986-11-04
标题 :Therapeutic agents
发明人：SMITHERS MICHAEL J
权利人:ICI PLC
摘要:The invention concerns novel therapeutic agents containing a (Z)-(2-alkoxyalkyl- or 2-aryloxyalkyl-4-phenyl-1,3-dioxan-5-yl)alkenoic acid, or a related tetrazole derivative, which antagonizes one or more of the actions of thromboxane A2, together with a compound which inhibits the synthesis of thromboxane A2. The compositions are useful as medicines in treating a variety of diseases or medical conditions in which thromboxane A2 and/or other prostanoid contractile substances are involved.