CAS: 52426-66-1; 5-(Chloromethyl)-2-Methylpyridine

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CAS号34107-46-5 6-甲基-3-甲醇吡啶 | CAS号106651-81-4 5-(氯甲基)-2-甲基吡啶盐酸盐 | CAS号5470-70-2 6-甲基烟酸甲酯 | CAS号52426-67-2 2-(6-甲基吡啶-3-基)乙腈

📜6-甲基烟酸甲酯置于lithium Aluminium Tetrahydride,氯化亚砜体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 3.0H,反应生成 5-(氯甲基)-2-甲基吡啶
参考文献:通往印za烷的模块化路线
标题:通往印za烷的模块化路线
摘要:描述了基于收敛性自由基的氮杂茚满路线,其依赖于各种取代的s-(吡啶甲基)-O-乙基二硫代碳酸酯(黄原酸酯)的退化加成转移至功能性烯烃,然后自由基环化至吡啶环上,所述吡啶环通过用三氟乙酸质子化而活化.在一种情况下,一个富于装饰环庚并[B]吡啶,可以迅速地通过允许第一加合物组装ñ苯基马来经历除了ñ之前环化-Allylphthalimide.
DOI:10.1021/acs.Orglett.7B01772

专利信息

专利号:US-2014303333-A1
优先权日:2011-10-14
标题:Iron bisphenolate complexes and methods of use and synthesis thereof
发明人：SHAVER MICHAEL P; KOZAK CHRISTOPHER M
权利人:UNIV PRINCE EDWARD ISLAND; GENESIS GROUP INC
摘要:The present application, relates to iron bisphenolate complexes and methods of use and synthesis thereof. The iron complexes are prepared from tridentate or tetradentate ligands of Formula I: wherein R 1 and R 2 are as defined herein. Also provided are methods and processes of using the iron bisphenolate complexes as catalysts in cross-coupling reactions and in controlled radical polymerizations.

专利号:US-7300639-B2
优先权日:2002-12-03
标 题:Process for removing metals from liquids
发明人：LIU WANSHENG
权利人:BRISTOL MYERS SQUIBB CO
摘要:A process is provided for removing one or more metals from liquids. Also provided is a process for the synthesis of aP2 inhibiting compounds having the formula (I) n nwherein R 1 , R 2 , R 3 , R 4 , HET, and X-Z are as described herein, which process comprising the step of removing one or more metals from a solution of the compound of formula I or an intermediate or precursor thereof. The processes for removing metal comprise the step of contacting the liquid with a solid extractant comprising a metal-binding functionality.

专利号:US-2023192718-A1
优先权日:2018-03-30
标 题 :Bicyclic enone carboxylates as modulators of transporters and uses thereof
发明人：SANDANAYAKA VINCENT
权利人:NIROGY THERAPEUTICS INC
摘要:The invention generally relates to the field of monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate enone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.

专利号:US-7576245-B2
优先权日:2002-07-11
标题:Fluorous tagging and scavenging reactants and methods of synthesis and use thereof
发明人：ZHANG WEI; LUO ZHIYONG
权利人:FLUOROUS TECHNOLOGIES INC
摘要:The present invention includes methods and compositions for increasing the fluorous nature of an organic compound by reacting it with at least one fluorous compound to produce a fluorous tagged organic compound. The increased fluorous nature of the fluorous tagged organic compound can then be utilized to separate the fluorous organic compound from untagged reagents, reactants, catalysts and/or products derived therefrom. The resultant fluorous tagged organic compound can be subjected to subsequent chemical transformations, wherein the fluorous nature of the tagged compound is utilized to increase the ease of separation of the fluorous tagged organic compound from untagged reagents, reactants, catalysts and/or products derived therefrom, after each chemical transformation. The chemical transformations result in a second fluorous tagged organic compound wherein the fluorous nature of the second fluorous tagged organic compound can then be reduced by removing the fluorous group therefrom, thereby producing a second organic compound that may be employed as a pharmaceutical compound or intermediate, or a combinatorial library component.

专利号:US-8916705-B2
优先权日:2011-10-14
标 题:Procaspase-activating compounds and compositions
发明人：HERGENROTHER PAUL J
权利人:UNIV ILLINOIS; TRUSTEES OF THE UNIVERSITY OF ILLILNOIS BOARD OF
摘要:The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.

专利号:US-8399684-B2
优先权日:2007-09-17
标题 :Sulfonamide-based organocatalysts and method for their use
发明人：CARTER RICH GARRETT; YANG HUA
权利人:CARTER RICH GARRETT; YANG HUA; OREGON STATE
摘要:Organocatalysts, particularly proline sulfonamide organocatalysts, having a first general formula as follows are disclosed. n nEmbodiments of a method for using these organocatalysts also are disclosed. The method comprises providing a disclosed organocatalyst, and performing a reaction, often an enantioselective or diastereoselective reaction, using the organocatalyst. Solely by way of example, disclosed catalysts can be used to perform aldol reactions, conjugate additions, Michael additions, Robinson annulations, Mannich reactions, α-aminooxylations, α-hydroxyaminations, α-aminations and alkylation reactions. Certain of such reactions are intramolecular cyclizations used to form cyclic compounds, such as 5-or 6-membered rings, having one or more chiral centers Disclosed organocatalysts generally are much more soluble in typical solvents used for organic synthesis than are known compounds. Moreover, the reaction yield is generally quite good with disclosed compounds, as is their enantioselective and diastereoselective effectiveness.