CAS: 511272-33-6; (R)-3-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-3-(4-Methoxyphenyl)Propanoic Acid

该化合物是一种非天然的氨基酸衍生物,其成分是受氟化物保护的矿物质组和4-methoxy-苯基侧链,该化合物由于与基于氟化物的战略相容,广泛用于peptide合成,特别是固相方法;甲基氧基组增强有机溶剂的溶解性,促进高效的混合反应;其立体化学纯度确保了化物组装的高选择性,使其对结构上界定的生物活性聚醚或聚苯胺具有价值;该产品具有一贯的质量,在标准处理条件下保持稳定性,以及自动合成器的可靠性能;它是药物研究以及开发基于丙石化的治疗的关键中间体.

英文名称(R)-3-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-3-(4-Methoxyphenyl)Propanoic Acid
中文名称Fmoc-(R)-3-氨基-3-(4-甲氧基苯基)-丙酸
IUPAC名称(R)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-methoxyphenyl)propanoic acid
其它别名(R)-3-芴甲氧羰酰基氨基-3-(4-甲氧基苯基)丙酸; Fmoc-D-3-Amino-3-(4-Methoxylphenyl)Propanoic Acid
CAS编号511272-33-6
MFCD编号:MFCD03428014
分子式:C25H23NO5
分子量:417.46
产品CID: 1500204
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: GXOCWIPOYXOZAF-HSZRJFAPSA-N
InChI=1S/C25H23NO5/c1-30-17-12-10-16(11-13-17)23(14-24(27)28)26-25(29)31-15-22-20-8-4-2-6-18(20)19-7-3-5-9-21(19)22/h2-13,22-23H,14-15H2,1H3…
计算化学: 氢键受体数4.0氢键供体数2.0可旋转键数7.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P280-P302+P352

上下游产品

CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl) | CAS号131690-57-8 (R)-3-氨基-3-(4-甲...

合成工艺路线路线简述

氯甲酸-9-芴基甲酯,(R)-3-氨基-3-(4-甲氧基苯基)丙酸置于sodium Carbonate体系中,用水,丙酮作为反应溶剂,以69%的收率获得产物(R)-Fmoc-4-甲氧基-Beta-苯丙氨酸
参考文献:Synthetic And Pharmacological Studies On New Simplified Analogues Of The Potent Actin-Targeting Jaspamide
标题:Synthetic And Pharmacological Studies On New Simplified Analogues Of The Potent Actin-Targeting Jaspamide
摘要:In The Recent Years,We Focused Our Attention On The Cyclodepsipeptide Jaspamide 1,An Interesting Marine Metabolite,Possessing A Potent Inhibitory Activity Against Breast And Prostate Cancer,As A Consequence Of Its Ability To Disrupt Actin Cytoskeleton Dynamics. Although Its Biological Pro. Le Has Been Well Determined,Many Mechanistic Details Are Still Missing In Terms Of Molecular Target Identification. For This Reason,We Decided To Synthetically Modify The Natural Metabolite,Obtaining Small Arrays Of Unnatural Variants Useful To Illuminate The Structural Requirements Essential For The Activity. Here,We Report The Synthesis Of Seven New Jaspamide Analogues 2-8,Containing,As The Parent Compound,A Beta-Amino Acid In The Cyclopeptide Backbone. Their Biological Pro. Le Is Also Described. (C) 2008 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2008.05.019