CAS: 511272-33-6; (R)-3-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-3-(4-Methoxyphenyl)Propanoic Acid

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CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl) | CAS号131690-57-8 (R)-3-氨基-3-(4-甲...

📜氯甲酸-9-芴基甲酯,(R)-3-氨基-3-(4-甲氧基苯基)丙酸置于sodium Carbonate体系中,用 水,丙酮 作为反应溶剂,以69%的收率获得产物(R)-Fmoc-4-甲氧基-Beta-苯丙氨酸
参考文献:Synthetic And Pharmacological Studies On New Simplified Analogues Of The Potent Actin-Targeting Jaspamide
标题:Synthetic And Pharmacological Studies On New Simplified Analogues Of The Potent Actin-Targeting Jaspamide
摘要:In The Recent Years,We Focused Our Attention On The Cyclodepsipeptide Jaspamide 1,An Interesting Marine Metabolite,Possessing A Potent Inhibitory Activity Against Breast And Prostate Cancer,As A Consequence Of Its Ability To Disrupt Actin Cytoskeleton Dynamics. Although Its Biological Pro. Le Has Been Well Determined,Many Mechanistic Details Are Still Missing In Terms Of Molecular Target Identification. For This Reason,We Decided To Synthetically Modify The Natural Metabolite,Obtaining Small Arrays Of Unnatural Variants Useful To Illuminate The Structural Requirements Essential For The Activity. Here,We Report The Synthesis Of Seven New Jaspamide Analogues 2-8,Containing,As The Parent Compound,A Beta-Amino Acid In The Cyclopeptide Backbone. Their Biological Pro. Le Is Also Described. (C) 2008 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2008.05.019