CAS: 494-08-6; 3-Methoxy-4-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Benzaldehyde

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CAS号51482-43-0 [3,4,5-triacety... | CAS号133-89-1 尿苷二磷酸葡萄糖 | CAS号121-33-5 香草醛 | CAS号50-99-7 D(+)-无水葡萄糖 | CAS号121-33-5 香草醛

📜4-O-(2',3',4',6'-Tetra-O-Acetyl-β-D-Glucopyranosyl)Vanillin置于sodium Methylate体系中,用 甲醇 作为反应溶剂,化学反应 1.0H,以75 Mg的收率获得产物4-(Beta-D-葡萄糖基)-3-甲氧基苯甲醛
参考文献:立体控制合成酚类α-D-甘露糖苷
标题:立体控制合成酚类α-D-甘露糖苷
摘要:致力于richard Schmidt教授对糖苷合成的开创性贡献 抽象的 据报道,采用"远程激活概念",以最少的保护基使用立体控制的糖苷合成,已报道了酚类1,2-顺式糖吡喃糖苷的一般合成,例如芳基α-D-半乳糖基,α-D-葡萄糖基和2-叠氮基α-D-吡喃葡萄糖苷,尤其是使用带有异头(3-溴-2-吡啶氧基)基团并由三氟甲磺酸甲酯催化的糖基供体. 据报道,采用"远程激活概念",以最少的保护基使用立体控制的糖苷合成,已报道了酚类1,2-顺式糖吡喃糖苷的一般合成,例如芳基α-D-半乳糖基,α-D-葡萄糖基和2-叠氮基α-D-吡喃葡萄糖苷,尤其是使用带有异头(3-溴-2-吡啶氧基)基团并由三氟甲磺酸甲酯催化的糖基供体.
DOI:10.1055/s-0035-1561461

专利信息

专利号:US-6372461-B1
优先权日:1998-09-18
标题 :Synthesis of vanillin from a carbon source
发明人：FROST JOHN W
权利人:DIRECTORS OPERATING MICHIGAN S
摘要:A bioengineered synthesis scheme for the production of vanillin from a carbon source is provided. The bioconversion methods of the present invention comprise the steps of microbe-catalyzed conversion of a carbon source to vanillic acid followed by enzyme-catalyzed reduction of the vanillic acid to produce vanillin. As shown in the synthesis scheme of FIG. 2, the microbe-catalyzed conversion step of the present invention requires five enzymes which are provided by a recombinant microbe. In a preferred embodiment, the recombinant microbe is Escherichia coli designed to cause dehydration of 3-dehydroshikimic acid and regioselective methylation of the resulting protocatechuic acid. The enzyme-catalyzed reduction step of the present invention comprises the reduction of vanillic acid to vanillin by aryl-aldehyde dehydrogenase.

专利号:WO-0017319-A2
优先权日:1998-09-18
标题:Synthesis of vanillin from a carbon source

专利号:EP-1114173-A2
优先权日:1998-09-18
标题 :Synthesis of vanillin from a carbon source

专利号:EP-1114173-A4
优先权日:1998-09-18
标题:SYNTHESIS OF VANILLIN FROM A CARBON SOURCE

专利号:CA-2344665-A1
优先权日:1998-09-18
标题 :Synthesis of vanillin from a carbon source