CAS: 38363-32-5; Penbutolol Sulfate

该化合物是一种非选择性的乙醇抗体,主要用于治疗高血压和某些类型的心脏疾病,其特点是能够阻塞乙醇-1和乙-2肾上腺受体,这有助于降低心率和较低的血压;该化合物通常以其硫酸盐的形式施用,提高其溶解性和生物利用率; Penbutolal 硫酸盐以其中度的亲脂性闻名,允许其有效穿透生物膜; 表现出相对较长的半衰期,允许临床环境中每天一次服用; 常见副作用包括疲劳,眩晕和胃肠扰动,反映其对心血管系统的系统性影响; 与其他乙醇阻塞剂一样,对于哮喘或慢性阻塞性肺病患者,由于潜在的溴胆固化作用,告诫他们谨慎行事; 总的来说, Penbutolulfate是治疗心血管疾病的宝贵治疗剂,临床实践中具有固定的特征.

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    专利号:US-9757463-B2
    优先权日:2012-06-15
    标题 :Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures
    发明人:HARTH EVA M; BEEZER DAIN B; LI GUANGZHAO; SPEARS BENJAMIN R; STEVENS DAVID M
    权利人:UNIV VANDERBILT
    摘要:Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    专利号:US-9745419-B2
    优先权日:2014-01-24
    标 题 :Aqueous polyglycidol synthesis with ultra-low branching
    发明人:HARTH EVA M; SPEARS BENJAMIN R
    权利人:UNIV VANDERBILT
    摘要:Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for a variety of applications, including, but not limited to, drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    专利号:WO-2024097977-A1
    优先权日:2022-11-04
    标题:Silk nanoparticle synthesis: tuning size, dispersity, and surface chemistry for drug delivery
    发明人:SHAIDANI SAWNAZ; FALCUCCI THOMAS; FOSTER OLIVIA; SAHOO JUGAL KISHORE; HASTURK ONUR; KAPLAN DAVID L; JACOBUS CHARLOTTE S
    权利人:TUFTS COLLEGE
    摘要:Methods disclosed herein relate to generating silk nanoparticles with a low polydispersity index (PDI). Methods include adding a silk solution dropwise into a volatile solvent that is miscible with water, thereby forming a precipitate-bearing solution and applying shear forces to the precipitate-bearing solution for a length of time sufficient to achieve evaporation of at least 95% of the volatile solvent, thereby producing a population of silk fibroin nanoparticles in water having a polydispersity index (PDI) of 0.35 or less, including but not limited to, a PDI of 0.330 or less, 0.325 or less, 0.315 or less, 0.310 or less, 0.30 or less, 0.275 or less, 0.250 or less, 0.225 or less, or 0.200 or less. Parameters related to silk fibroin molecular weight, silk fibroin concentration, shear force application, and temperature may all be modified to achieve silk nanoparticles of a particular size exhibiting particular PDIs.

    专利号:US-2016206743-A1
    优先权日:2012-06-15
    标题 :Linear Polyester and Semi-Linear Glycidol Polymer Systems: Formulation and Synthesis of Novel Monomers and Macromolecular Structures

    专利号:US-2014005278-A1
    优先权日:2012-06-15
    标题 :Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures

    专利号:US-9161983-B2
    优先权日:2012-06-15
    标题:Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures

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    主要参考文献


    1: Ita KB, Popova IE. Influence of sonophoresis and chemical penetration enhancers on percutaneous transport of penbutolol sulfate. Pharm Dev Technol. 2015 Sep
    18:1-6. [Epub ahead of print] doi: 10.1080/10717540802396976. Chinese. Italian. German.

    合成参考文献


    摘要:Iyakuhin Kenkyu. Study of Medical Supplies., 16(590), 1985
    摘要:Oyo Yakuri. Pharmacometrics., 21(1001), 1981
    参考文献:10.1023/a:1016156927420
    摘要:Taillardat-Bertschinger A, Martinet CA, Carrupt PA, Reist M, Caron G, Fruttero R, Testa B. Molecular factors influencing retention on immobilized artifical membranes (IAM) compared to partitioning in liposomes and n-octanol. Pharm Res. 2002 Jun;19(6):729–37. doi: 10.1023/a:1016156927420.
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