📜5-乙基-2-甲基-吡啶置于chromium(Vi) Oxide,硫酸,乙酸酐,Sodium Carbonate体系中,用 溶剂黄146,水 作为反应溶剂,化学反应 24.0H,反应生成 5-乙酰基-2-甲基吡啶 参考文献: Pyridazin-3 (2H)-One Derivatives And Their Use As Pde4 Inhibitors[fr] Derives De Pyridazine-3(2H)-Ones Et Utilisation En Tant Qu'Inhibiteurs De Pde4 标题: Pyridazin-3 (2H)-One Derivatives And Their Use As Pde4 Inhibitors[fr] Derives De Pyridazine-3(2H)-Ones Et Utilisation En Tant Qu'Inhibiteurs De Pde4 摘要:新吡啶唑-E-(2H)-酮衍生物,具有通用公式(I)的化学结构被公开;以及它们的制备过程,包含它们的药物组合物以及它们作为磷酸二酯酶4抑制剂的疗法使用.
专利号:US-8703952-B2 优先权日:2008-12-12 标题:Synthesis of 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline and analogues and intermediates 发明人:WILLIAMSON CRAIG; STOREY JOHN MERVYN DAVID 权利人:WILLIAMSON CRAIG; STOREY JOHN MERVYN DAVID; WISTA LAB LTD 摘要:The present invention pertains generally to methods of preparing certain 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline compounds and their analogues, and especially to methods of preparing dimebon. The present invention also pertains to methods of preparing certain intermediate compounds which find use in the synthesis of the 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline compounds.
专利号:US-8664402-B2 优先权日:2011-03-09 标题:Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of etoricoxib 发明人:CASTELLIN ANDREA; STABILE PAOLO; FONTANA FRANCESCO; DE LUCCHI OTTORINO; CAPORALE ANDREA; TARTAGGIA STEFANO 权利人:CASTELLIN ANDREA; STABILE PAOLO; FONTANA FRANCESCO; DE LUCCHI OTTORINO; CAPORALE ANDREA; TARTAGGIA STEFANO; ITALIANA SINT SPA 摘要:A process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methyl sulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. The synthesis of the intermediates useful for such preparation is also described.
专利号:US-8501941-B2 优先权日:2005-02-25 标题 :Methods for the synthesis of unsymmetrical cycloakyl substituted xanthines 发明人:WANG GUOQUAN; RIEGER JAYSON M; THOMPSON ROBERT D 权利人:WANG GUOQUAN; RIEGER JAYSON M; THOMPSON ROBERT D; DOGWOOD PHARMACEUTICALS INC 摘要:The present invention provides compounds and pharmaceutical compositions that are selective antagonists of A 2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents. Also provided are processes for the preparation of the compounds and their intermediates.
专利号:US-8765962-B1 优先权日:2013-01-22 标题:Very efficient process for preparing an intermediate of etoricoxib 发明人:STABILE PAOLO; GALVAGNI MARCO 权利人:F I S —FABBRICA ITALIANA SINT S P A; F I S —FABRICA ITALIANA SINT S P A 摘要:The present invention relates to an efficient process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. Water is employed as reaction medium.
专利号:US-10906888-B2 优先权日:2016-07-14 标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme 发明人:CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE 权利人:PFIZER 摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
专利号:US-2007105821-A1 优先权日:2005-02-25 标 题 :Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines