CAS: 34259-99-9; 4-Bromothiazole

上下游产品

2,4-二溴噻唑 2,4-Dibromo-1,3-Thiazole 4175-77-3

3-甲硫基噻吩置于n-溴代丁二酰亚胺(Nbs)体系中,用 水,溶剂黄146 作为反应溶剂,化学反应生成 4-溴噻唑
参考文献:(3-Amino-1-Propynyl)Methylthiothiophene Derivatives
标题:(3-Amino-1-Propynyl)Methylthiothiophene Derivatives
摘要:可以使用以下结构式表示的药物化合物和组合物:##str1## 其中nr'"选择自氨基,(C.Sub.1-C.Sub.6)烷基氨基,二烷基氨基或三烷基氨基,吡咯烷基或哌啶基.这些化合物和组合物可用于治疗哺乳动物的中枢胆碱能功能障碍.

专利信息

专利号:US-2025179012-A1
优先权日:2022-03-04
标 题:Synthesis of sulfur(vi) compounds and reagents for same
发明人：LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-2024368190-A1
优先权日:2023-04-14
标题:Synthesis of ras inhibitors
发明人：LI SHAOLING; MANTHATI SURESH; WANG ROSS; BALLMER STEVE; HUANG XIAOJUN
权利人:REVOLUTION MEDICINES INC
摘要:The present invention relates to Ras inhibitors and to methods for preparing Ras inhibitors.

专利号:WO-2023168108-A2
优先权日:2022-03-04
标 题 :Synthesis of sulfur(vi) compounds and reagents for same

专利号:US-2023025807-A1
优先权日:2019-10-30
标题:Cd38 inhibitors
发明人：KULKARNI SANTOSH S; LAGU BHARAT; WU XINYUAN
权利人:MITOBRIDGE INC
摘要:The present invention is directed to a compound of Formula (I) or a pharmaceutically acceptable salt thereof. Compounds of Formula (I) are CD38 inhibitors, which can be used to treat a disease or condition in a subject that benefits from an increase in NAD + or to treat a mitochondrial disorder in a subject. Such disease or condition is a muscle structure disorder, a neuronal activation disorder, a muscle fatigue disorder, a muscle mass disorder, a metabolic disease, a cancer, a vascular disease, an ocular vascular disease, a muscular eye disease, or a renal disease. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 30 to 135; examples 1 to 61; table). Such an exemplary compound is e.g. N-((1r,4r)-4-(2-methoxyethoxy) cyclohexyl)-5-(thiazol-5-yl)-1H-indole-7-carboxamide (II).

专利号:US-9938258-B2
优先权日:2012-11-29
标 题:Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHECHTER SHARON; SHACHAM SHARON; MCCAULEY DILARA; SENAPEDIS WILLIAM; GOLAN GALI; KALID ORI
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula I: n nor a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.