CAS: 25333-24-8; Methyl 4-Oxo-4-Phenylbutanoate

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CAS号2051-95-8 3-苯甲酰丙酸 | CAS号100-52-7 苯甲醛 | CAS号292638-85-8 丙烯酸甲酯 | CAS号3878-55-5 丁二酸单甲酯 | CAS号98-80-6 苯硼酸 | CAS号2046-17-5 4-苯基丁酸甲酯 | CAS号33553-90-1 4-hydroxy-4-phe... | CAS号17851-98-8 tributyl(1-phen... | CAS号96-32-2 溴乙酸甲酯 | CAS号74-88-4 碘甲烷 | CAS号37779-49-0 3-氧代-4苯基丁酸甲酯 | CAS号939-52-6 4-氯-1-羰基-1-苯基丁烷 | CAS号2051-95-8 3-苯甲酰丙酸 | CAS号1006-64-0 2-苯基吡咯烷 | CAS号1011-46-7 4,5-二氢-6-苯基-3(2... | CAS号34272-66-7 (2-甲基-4-苯基-噻唑-5... | CAS号3365-26-2 CYCLOBUTENYLBENZENE | CAS号2046-17-5 4-苯基丁酸甲酯 | CAS号20958-78-5 3-phenylpyrrolo... | CAS号7498-88-6 4,4-二苯基-3-丁烯酸

4-苯丁酸甲酯置于manganese(II) Chloride Tetrahydrate,水,间氯过氧苯甲酸,4,4',4''-三叔丁基2,2',6'2''-曲吡啶体系中,用 乙腈 用作溶剂,化学反应 4.0H,以41%的收率获得3-苯基丙酸甲酯
参考文献:锰催化剂合成羰基化合物的统一氧化方案
标题:锰催化剂合成羰基化合物的统一氧化方案
摘要:我们已经开发出用于将醚,苄基化合物和醇氧化为羰基化合物的统一协议.该方案使用催化量的四水合氯化锰(II)和4,4',4'-三(叔丁基)-2,2':6',2''-吡啶和化学计量的任何一种间氯过苯甲酸(mcpba)或过氧硫酸氢钾(khso 5).由mn催化剂和mcpba组成的试剂体系使烷基醚和苄基化合物的化学选择性sp³ch氧化生成相应的酮.或者,水溶性无机盐khso 5与mn催化剂结合使用可将醇氧化为酮或羧酸.重要的是,Mn催化剂/ Khso 5系统消除了与分离羧酸产物相关的技术难题.本专题文章中提出的所有氧化反应均在有氧气氛中于低于环境温度的温度下进行,因此可用于复杂有机分子的实际合成中. 催化-氧化-醚-醇-酮-羧酸
Doi:10.1055/s-0029-1218809

专利信息

专利号:US-6838581-B2
优先权日:2002-12-04
标题:Process for the preparation of enantiomerically pure 3-phenyl-3-hydroxypropylamine
发明人：KUMAR PRADEEP; PANDEY RAJESH KUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to an improved process for the synthesis of enantiomerically pure 3-phenyl-3-hydroxypropylamine of formula I; more particularly the present invention relates to the said process using styrene; n n nthe synthetic strategy features a Sharpless asymmetric dihydroxylation (SAD) route to the target compound, using styrene, a readily accessible starting material gives the optically pure dihydroxy compound (ee >97%; the selective monotosylation of primary alcohol, nucleophilic displacement by cyano and subsequent reduction to amino group furnishes the desired 3-phenyl-3-hydroxypropylamine in enatiomerically pure form, a key intermediate in the synthesis of variety of oxetine related anti-depressant drugs.

专利号:US-6028224-A
优先权日:1998-06-22
标 题 :Fluoxetine process from benzoylpropionic acid
发明人：HILBORN JAMES WALLACE; JURGENS ALEX ROGER; SENANAYAKE CHRIS HUGH
权利人:SEPRACOR INC
摘要:A synthesis of fluoxetine is disclosed. The process begins with a lower alkyl ester of 3-benzoylpropionic acid, which is reduced in the presence of a chiral ligand to produce the corresponding γ-hydroxy ester, and the ester is cleaved. The free acid is then condensed with the alcohol to form a γ-lactone, which is treated with ammonia to provide the γ-hydroxy amide. The amide undergoes a Hoffman rearrangement to provide a 2-oxo-1,3 oxazine, which is reduced to 3-(methylamino)-1-phenyl-1-propanol. The alcohol is deprotonated and reacted with a 4-chloro- or 4-fluoro benzotrifluoride to provide fluoxetine free base.

专利号:CN-112300047-A
优先权日:2019-08-01
标题 :A kind of method for tandem reductive amination synthesis of chiral lactam

专利号:CN-106831665-A
优先权日:2016-12-14
标题 :Enantioselective synthesis of γ-substituted-γ-butyrolactone and δ-substituted-δ-valerolactone

专利号:CN-112300047-B
优先权日:2019-08-01
标题 :A kind of method of tandem reductive amination synthesis chiral lactam