CAS: 21637-25-2; 3-(((2S,3R,4R,5R)-5-((R)-1,2-Dihydroxyethyl)-3,4-Dihydroxytetrahydrofuran-2-yl)Oxy)-2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxy-4H-Chromen-4-One

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CAS号50-99-7 D(+)-无水葡萄糖 | CAS号117-39-5 槲皮素

📜芦丁置于α-L-Rhamnosidase From Aspergillus Niger Jmu-Ts528体系中,化学反应 1.0H,以95.1%的收率获得异槲皮苷
参考文献:使用黑曲霉jmu-Ts528的α-L-鼠李糖苷酶对芦丁进行生物转化制备异槲皮苷,并进行hsccc纯化.
标题:使用黑曲霉jmu-Ts528的α-L-鼠李糖苷酶对芦丁进行生物转化制备异槲皮苷,并进行hsccc纯化.
摘要:异槲皮苷是类黄酮,在制药和营养保健行业中具有重要的应用.然而,低产率和高生产成本阻碍了异槲皮苷的工业制备.在本研究中,通过使用黑曲霉jmu-Ts528的α-L-鼠李糖苷酶与高速逆流色谱(hsccc)纯化,通过芦丁的生物转化制备异槲皮苷.结果,最佳转化ph,温度和时间分别为ph 4.0,60oc和60 Min.Km和vmax分别为0.36 Mm和0.460 Mmol / Min.对于异槲皮苷的生产,最佳芦丁浓度和转化时间约为1000 Mg / L和60分钟.芦丁转化率达到96.44%.使用hsccc一步纯化将异槲皮苷纯化至97.83%的纯度.使用uplc-Q-Tof-Ms鉴定了异槲皮苷.综合结果表明,利用黑曲霉jmu-Ts528的α-L-鼠李糖苷酶与hsccc的结合进行生物转化是制备异槲皮苷的简单有效的方法,可能有助于工业生产异槲皮苷.
Doi:10.1080/10826068.2019.1655763

专利信息

专利号:US-2012208198-A1
优先权日:2007-01-11
标 题:Novel gene encoding myb transcription factor involved in proanthocyanidin synthesis
发明人：BOGS JOCHEN; WALKER AMANDA RUTH; ROBINSON SIMON PIERS
权利人:BOGS JOCHEN; WALKER AMANDA RUTH; ROBINSON SIMON PIERS; COMMW SCIENT IND RES ORG
摘要:An isolated or recombinant MYB polypeptide having activity as a transcription factor in the synthesis of proanthocyanidins in plants, and nucleic acid molecule encoding same, wherein the polypeptide activates in the plants (a) promoters of the leucoanthocyanidin (LAR) and anthocyanidid reductase (ANR) genes, and (b) promoters of at least two of the genes of the general flavonoid pathway. Use of the polypeptide and nucleic acid molecule in regulating the biosynthesis and accumulation of proanthocyanidins in plants, such as in modifying pasture quality of legumes, is also disclosed.

专利号:US-2002165207-A1
优先权日:2001-05-02
标题 :Compositions and methods for the treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD
摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

专利号:US-2006115880-A1
优先权日:2002-12-03
标 题 :Enzymatic production of acyl flavonoid derivatives
发明人：GHOUL MOHAMED; ENGASSER JEAN-MARC; MOUSSOU PHILIPPE; PAULY GILLES; ARDHAOUI MELIKA; FALCIMAIGNE AUDE
权利人:COGNIS FRANCE SA
摘要:Disclosed is a method for enzymatic synthesis of esters of flavonoid and flavonoid derivatives, according to which a reaction medium containing an organic solvent, a glycosylated flavonoid or aglycon flavonoid, an acyl group donor, and an enzymatic catalyst is produced, b) additional quantities of flavonoid and/or acyl donor are optionally added during the reaction, and c) the obtained esters are separated from the enzymatic particles and the solvent. The inventive method is characterized by maintaining the concentration of water and/or alcohol which are formed during the reaction to below 150 mM. Advantageously, the molar ratio of flavonoid to acyl donor in the reaction medium is maintained in the range from 0.01 to 20.00 during the reaction.

专利号:US-7914823-B2
优先权日:2000-12-21
标题 :Method and composition for the topical treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD ALLEN
权利人:PROPHASE LABS INC
摘要:A method and composition for the treatment of diabetic neuropathy is disclosed. The composition comprises a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant formulated in a pharmaceutically acceptable carrier. It has been found that this combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In view of the consensus in the art that effective combinations of various active agents have not been demonstrated to be effective for the treatment of diabetic neuropathy, the present invention provides a surprising and unexpected effect. In addition, the topical compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the topical administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is topically administered to the areas of the body that have been adversely affected by the diabetic neuropathy on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms and at least some recovery of the damaged nerve tissues.

专利号:CN-101985639-B
优先权日:2010-11-16
标 题:Application of α-L-rhamnosidase in biotransformation of rutin for directed synthesis of isoquercitrin

专利号:CN-115197951-A
优先权日:2022-05-10
标 题 :The candidate gene CsNAC086 for the synthesis of flavonols from tea tree and its application