CAS: 2051-62-9; 4-Chlorobiphenyl

上下游产品

biphenyl 4-Phenylphenol bis(4-chlorobenzoyl)peroxide 4-phenylalanine 1,3-diphenylbenzene [1,1';4',1'']terphenyl 2-(4'-chloro-biphenyl-4-carbonyl)-benzoic acid tris-biphenyl-4-yl-phenyl-silane

📜三氟甲磺酸-4-氯苯醚置于锰,Copper(L) Iodide,四(三苯基膦)钯,5 5'-二甲基-2,2'-二吡啶,四丁基氟化铵,Nickel Dichloride体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 48.0H,反应生成4-氯联苯
参考文献:乙烯基氯硅烷的跨亲电csp2-Si偶联.
标题:乙烯基氯硅烷的跨亲电csp2-Si偶联.
摘要:亲电子交联已成为形成c-C键的有力工具,但其锻造c-Si键的潜力仍未得到开发.在这里,我们报告了乙烯基/芳基亲电体与乙烯基氯硅烷的交叉亲电体csp 2-Si偶联反应.该新方案提供了一种从容易获得的材料中轻松,精确地合成具有高分子多样性和复杂性的有机硅烷的方法.反应在温和和非碱性条件下进行,这表明该方法具有较高的步骤经济性,广泛的底物范围,广泛的功能公差和易于扩展的特性.该方法的综合实用性通过有效利用硅生物等排体,新型bcb单体的设计以及对乙烯基硅烷产品的hiyama交叉偶联的研究而得以展示.
Doi:10.1002/anie.202010737

专利信息

专利号:US-6048991-A
优先权日:1990-11-16
标题:Preparation of epoxides
发明人：HAERMELING DIETER
权利人:BASF AG
摘要:Alpha-hydroxy-epoxides of alpha-alkoxy-epoxides of the formula IV ##STR1## in which the substituents have the following meanings: R 7 , R 8 , R 9 , R 10 , R 11 are independently hydrogen, C 1 -C 20 -alkyl, C 3 -C 12 -cycloalkyl, C 4 -C 20 -cycloalkylalkyl, C 1 -C 20 -hydroxy-alkyl, a heterocyclic ring, or an aryl or C 7 -C 20 -arylalkyl group optionally substituted by C 1 -C 8 -alkyl, C 1 -C 8 -alkoxy, halogen, C 1 -C 4 -haloalkyl, C 1 -C 4 -halo-alkoxy, phenyl, phenoxy, halophenyl, halophenoxy, carboxy, C 2 -C 8 -alkoxycarbonyl, or cyano, or R 7 and R 8 or R 7 and R 9 or R 7 and R 10 or R 9 and R 10 or R 10 and R 11 together form a (CH 2 ) n group in which n is an integer from 1 to 10 and which may be optionally substituted by C 1 -C 8 -alkyl, C 1 -C 8 -alkoxy, and/or halogen, and n R 12 is hydrogen, C 1 -C 8 -alkyl, or benzyl, n provided that R 10 is not hydrogen, methyl, ethyl, propyl, or cyclohexyl when R 7 , R 8 , R 9 , or R 11 is hydrogen, that R 7 is not methyl when R 8 is methyl or phenyl and R 9 , R 10 , or R 11 is hydrogen, that R 7 is not methyl when R 8 , R 9 , R 10 , or R 11 is hydrogen and R 12 is ethyl, that R 7 is not phenyl or hexyl when R 8 , R 9 , R 10 , or R 11 is hydrogen, that R 9 is not methyl when R 7 , R 8 , R 10 , or R 11 is hydrogen, that R 10 and R 11 are not methyl when R 7 , R 8 , or R 9 is hydrogen, and that R 7 and R 10 do not together form an unsubstituted cycloalkyl when R 8 , R 9 , or R 11 is hydrogen. The epoxides of the above formula serve as intermediates for the synthesis of, inter alia, perfumes, plant protectants and polymers.

专利号:US-4808607-A
优先权日:1985-05-22
标题 :Imidazole analogs of mevalonolactone and derivatives thereof for use in inhibiting cholesterol biosynthesis and lowering blood cholesterol level
发明人：WAREING JAMES R
权利人:SANDOZ PHARMACEUTICALS CORP
摘要:Compounds of the formula and the pharmaceutically acceptable acid addition salts thereof, wherein the various substituents are defined hereinbelow and the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.

专利号:US-9803050-B2
优先权日:2014-10-08
标 题:Dispersant for use in synthesis of polyaryletherketones
发明人：NAIR KAMLESH P
权利人:TICONA LLC
摘要:A method for forming a polyaryletherketone is described. More particularly, a reaction mixture is initially supplied to the reactor vessel that contains one or more precursor monomers. A heteroaryl compound is also added to the reaction mixture. The reaction can be carried out according to, e.g., an electrophilic aromatic substitution reaction or a nucleophilic aromatic substitution reaction. The heteroaryl compound can serve as a dispersant to the polymer as it is formed. This minimizes the likelihood of gelling of the product polymer within the reactor vessel and limits the impact of process disruptions on the production of the polyaryletherketone.

专利号:US-11344858-B2
优先权日:2019-05-02
标 题 :Micro-electrolysis reactor for ultra fast, oxidant free, C—C coupling reaction and synthesis of daclatasvir analogs thereof
发明人：SINGH AJAY KUMAR; PABBARAJA SRIHARI; GHOSH SUBHASH; BHUSHAN MAHAJAN; MUJAWAR TAUFIQUEAHMED
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a continuous micro-electro-flow reactor system for ultra-fast, oxidant free, C—C coupling reaction for making symmetrical biaryls and analogs thereof. This invention further relates to the said process for preparation of antiviral drug, daclatasvir of general formula I.

专利号:US-12364961-B2
优先权日:2021-01-13
标 题 :Multiplex synthesis method of compound library and parallel synthesizer of compound library using same
发明人：KIM DONG PYO; AHN GWANG NOH
权利人:POSTECH RES & BUSINESS DEV FOUND
摘要:The present invention relates to a parallel synthesis method and synthesizer of a compound library, and more specifically provides a parallel synthesis method and synthesizer of a compound library, which uniformly distribute a first reactant and perform independent reactions in separate spaces, and since it is possible to confirm the results for various reaction variables at once, the synthesis time of the compound library can be reduced with a high synthesis yield of the product.

专利号:WO-2024258613-A9
优先权日:2023-06-16
标题:Tetrachlorovancomycin and derivatives
发明人：BOGER DALE
权利人:SCRIPPS RESEARCH INST
摘要:A total synthesis of a new class of vancomycin analogues of reduced synthetic complexity was developed. The synthesis, achieved by the addition of two aryl chloride substituents to provide tetrachlorovancomcyin aglycon (Compound II), tetrachlorovancomcyin (Compound I ), and their derivatives, permitted a streamlined total synthesis of the new class of glycopeptide antibiotics by removing atropisomer stereochemical control and enabled the simultaneous and further activated SNAr macrocyclizations that establish the tricyclic skeleton of Compound I. In addition to the antimicrobial evaluation of tetrachlorovancomycin (Compound I), the preparation of key binding pocket and peripherally-modi fied derivatives, which overcome vancomycin resistance and introduce independent and synergistic mechanisms of action, revealed their exceptional antimicrobial potency and provide the foundation for use of this new class of synthetic glycopeptide analogues. Also disclosed are a pharmaceutical composition containing bactericidal amount of tetrachlorovancomycin, a derivative thereof or a salt of either dissolved or dispersed in a pharmaceutically acceptable diluent.