CAS: 202865-73-4; 2-Bromo-4-Fluoroiodobenzene

上下游产品

2-bromo-4-fluoroaniline 4-fluoroaniline

2-溴-4-氟苯胺置于盐酸,Sodium Nitrite,Potassium Iodide体系中,用 水 用作溶剂,以68%的收率获得2-溴-4-氟-1-碘苯
参考文献:钌催化的涉及碳-碳三键断裂的2,2'-二乙炔基-联苯的环异构化
标题:钌催化的涉及碳-碳三键断裂的2,2'-二乙炔基-联苯的环异构化
摘要:钌配合物催化新的2,2'-二乙炔基联苯的环异构化反应,形成9-乙炔基菲,从而裂解了原始乙炔基的碳-碳三键.由两个乙炔基之一生成金属-亚乙烯基配合物,其碳-碳双键与另一个乙炔基进行[2 + 2]环加成反应,形成环丁烯.菲骨架是由随后的环丁烯部分的电环开环构成的.
Doi:10.1002/chem.201504937

专利信息

专利号:US-2011130567-A1
优先权日:2009-06-03
标题 :Steroselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：FANDRICK DANIEL R; REEVES JONATHAN T; SONG JINHUA J; TAN ZHULIN; QU BO; YEE NATHAN K; RODRIGUEZ SONIA
权利人:BOEHRINGER INGELHEIM INT
摘要:A process for stereoselective synthesis of a compound of Formula (X) n n n n n n n n n n wherein:n R 1 is an aryl group substituted with one to three substituent groups,n wherein each substituent group of R 1 is independently C 1 -C 5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromethyl,n wherein each substituent group of R 1 is optionally independently substituted with one to three substituents selected from C 1 -C 3 alkyl, C 1 -C 3 alkoxy, phenyl, and alkoxyphenyl; n n R 2 and R 3 are each independently C 1 -C 5 alkyl; R 4 is C 1 -C 5 alkyl optionally independently substituted with one to three substituent groups,n wherein each substituent group of R 4 is independently C 1 -C 3 alkyl, hydroxy, halogen, amino, or oxo; and n R 5 is a heteroaryl group substituted with one to three substituent groups,n wherein each substituent group of R 5 is independently C 1 -C 5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylsulfonylamino, aminosulfonyl, C 1 -C 5 alkylaminosulfonyl, C 1 -C 5 dialkylaminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, or C 1 -C 5 alkylthio wherein the sulfur atom is optionally oxidized to a sulfoxide or sulfone.

专利号:US-2010312013-A1
优先权日:2009-06-03
标 题:Steroselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：FANDRICK DANIEL R; YEE NATHAN K; SONG JINHUA J; REEVES JONATHAN T
权利人:BOEHRINGER INGELHEIM INT
摘要:A process for synthesis of a compound of Formula (X) n n n n n n n n n n wherein:n R 1 is an aryl group substituted with one to three substituent groups,n wherein each substituent group of R 1 is independently C 1 -C 5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromethyl,n wherein each substituent group of R 1 is optionally independently substituted with one to three substituents selected from C 1 -C 3 alkyl, C 1 -C 3 alkoxy, phenyl, and alkoxyphenyl; and n n R 2 and R 3 are each independently C 1 -C 5 alkyl.

专利号:WO-2010141331-A2
优先权日:2009-06-03
标 题 :Stereoselective synthesis of certain trifluoromethyl-substituted alcohols

专利号:CN-105669590-B
优先权日:2016-03-08
标 题:Catalyst-free synthesis of phenothiazine drug intermediates

专利号:WO-2010141334-A1
优先权日:2009-06-03
标 题:Synthesis of certain trifluoromethyl ketones

专利号:CN-108395424-A
优先权日:2018-02-08
标 题:A method for the synthesis of benzothiophene derivatives from copper-catalyzed dihalogenated arenes under microwave radiation