CAS: 1867-66-9; (+/-)-Ketamine Hydrochloride

上下游产品

(2-chlorophenyl)(cyclopentyl)methanone 2-Chlorobenzonitrile (+/-)-(2-chlorophenyl)(1-hydroxycyclopentyl)methanone 1-((2-chlorophenyl)(methylimino)methyl)cyclopentan-1-olDL-N-Nitrosoketamin

📜盐酸羟亚胺置于aluminum (III) Chloride,苯甲酸乙酯体系中,化学反应 5.0H,以93.6%的收率获得盐酸氯氨酮
参考文献:氯胺酮的工艺研究和杂质控制策略
标题:氯胺酮的工艺研究和杂质控制策略
摘要:已经开发了一种改进的(S)-氯胺酮(esketamine)合成方法,该方法成本效益高,不需要的异构体可通过外消旋作用回收.确定每个步骤的关键工艺参数以及与工艺相关的杂质.首先讨论了大多数杂质的形成机理和控制策略.此外,(S)-酒石酸氯胺酮是二水合物,这是首次公开.由氯化铝催化的可行外消旋以定量收率进行,纯度为99%.Ich级质量(s通过手性拆分和三倍的母液回收率,可得到5-氯胺酮盐酸盐,总产率为51.1%(无外消旋作用为14.0%).氯胺酮的稳健工艺可以在工业上推广.
Doi:10.1021/acs.Oprd.9B00553

专利信息

专利号:US-11613514-B2
优先权日:2016-03-25
标题:Crystal forms and methods of synthesis of (2R, 6R)-hydroxynorketamine and (2S, 6S)-hydroxynorketamine
发明人：THOMAS CRAIG; ZARATE CARLOS; MOADDEL RUIN; GOULD TODD; ZANOS PANOS; MORRIS PATRICK
权利人:US HEALTH; UNIV MARYLAND
摘要:The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketamine (HNK) includes preparation of (R)-norketamine via chiral resolution from racemic norketamine via a chiral resolution with L-pyroglutamic acid. The disclosure also provided crystal forms of the corresponding (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine hydrochloride salts.

专利号:US-9828452-B1
优先权日:2004-11-11
标 题 :Process for the synthesis of poly (vinyl alcohol) and/or poly (vinyl acetate) with spherical morphology and shell-and-nucleus structure and its use in vascular embolization
发明人：COSTA DA SILVA PINTO JOSÉ CARLOS; Niemeyer Limeira Mariana Araújo; SILVA FABRICIO MACHADO; MELO PRIAMO ALBUQUERQUE; DE SOUZA Mà RCIO NELE; Lopez Galdêncio Espinosa
权利人:COSTA DA SILVA PINTO JOSÉ CARLOS; Niemeyer Limeira Mariana Araújo; SILVA FABRICIO MACHADO; MELO PRIAMO ALBUQUERQUE; DE SOUZA Mà RCIO NELE; Lopez Galdêncio Espinosa; INST ALBERTO LUIZ COIMBRA DE PÓS-GRADUAÇÃO E PESQUISA DE ENGENHARIA—COPPE; FIRST LINE IND E COMMERCIA S/A
摘要:The present invention describes a process for the synthesis of spherical particles of polyvinyl alcohol—PVA and/or polyvinyl acetate—PVAc with shell nucleus structure from total or partial hydrolysis in a caustic aqueous medium with obtaining particulates of PVA/PVAc with controlled spherical morphology, to be used in vascular embolization.

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:US-2009325858-A1
优先权日:2003-03-21
标 题:Reduction of Zinc-Induced Neurotoxic Injury By Blockade of Nitric Oxide Synthesis
发明人：FREDERICKSON CHRISTOPHER J
权利人:ANDRO DIAGNOSTICS INC
摘要:The present invention provides methods of inhibiting release of zinc from neurons and of preventing zinc-mediated brain injury. Also provided are methods of improving cerebral blood flow while preventing zinc-mediated brain injury. Inhibitors of or activators of nitric oxide synthases modulate nitric oxide synthesis to reduce nitric oxide-induced release of neurotoxic amounts of zinc, thereby reducing zinc-mediated neuronal injury after brain trauma.

专利号:WO-2024110191-A1
优先权日:2022-11-22
标 题:Codon-optimized oligonucleotide for induction of elastin de-novo synthesis in mammals
发明人：AVCI-ADALI MELTEM; WENDEL HANS-PETER; GOLOMBEK SONIA
权利人:UNIV TUEBINGEN MEDIZINISCHE FAKULTAET
摘要:The present invention relates to oligonucleotides for induction of elastin de-novo synthesis in mammals, a method of treatment of diseases and medical conditions associated with insufficient tissue elasticity, use of the oligonucleotide in such treatment, as well as pharmaceutical and cosmetical compositions comprising such oligonucleotide.

专利号:US-6030613-A
优先权日:1995-01-17
标题:Receptor specific transepithelial transport of therapeutics
发明人：BLUMBERG RICHARD S; SIMISTER NEIL E; LENCER WAYNE I
权利人:BRIGHAM & WOMENS HOSPITAL; UNIV BRANDEIS
摘要:The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.