CAS: 1793080-72-4; (4-(2-(4-Fluoro-2-Methylphenoxy)-4-(Trifluoromethyl)Benzamido)-2-Oxopyridin-1(2H)-yl)Methyl Dihydrogen Phosphate
- 英文名称(4-(2-(4-Fluoro-2-Methylphenoxy)-4-(Trifluoromethyl)Benzamido)-2-Oxopyridin-1(2H)-yl)Methyl Dihydrogen Phosphate
- 中文名称(4-(2-(4-氟-2-甲基苯氧基)-4-(三氟甲基)苯甲酰氨基)-2-氧代吡啶-1(2H)-基)甲基N磷酸酯
- IUPAC名称(4-(2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxopyridin-1(2H)-yl)methyl dihydrogen phosphate
- 其它别名(4-(2-(4-Fluoro-2-Methylphenoxy)-4-(Trifluoromethyl)Benzamido)-2-Oxo-1L4,2L5-Pyridin-1-yl)Methyldihydrogenphosphate; (4-(2-(4-Fluoro-2-Methylphenoxy) -4-(Trifluoromethyl)Benzamido) -2-Oxopyridin-1(2H)-yl)Methyl Dihydrogen Phosphate; Benzamide, N-[1,2-Dihydro-2-Oxo-1-[(Phosphonooxy)Methyl]-4-Pyridinyl]-2-(4-Fluoro-2-Methylphenoxy)-4-(Trifluoromethyl)-; Sorafenib Impurity 86; Pramipexole Impurity 66-D5 Dihydrochloride
- CAS编号1793080-72-4
- MFCD编号:MFCD34184505
- 分子式:C21H17F4N2O7P分子量:516.34
- 产品CID: 922496
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- 2905110000-甲醇
2912110000-甲醛
2912210000-苯甲醛
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主要参考文献
1: Vaelli P, Fujita A, Jo S, Zhang HB, Osorno T, Ma X, Bean BP. State-Dependent Inhibition of Nav1.8 Sodium Channels by VX-150 and VX-548. Mol Pharmacol. 2024 Nov 18;106(6):298-308. doi: 10.1124/molpharm.124.000944.
2: Hijma HJ, Siebenga PS, de Kam ML, Groeneveld GJ. A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults. Pain Med. 2021 Aug 6;22(8):1814-1826. doi: 10.1093/pm/pnab032.
3: Alles SRA, Smith PA. Peripheral Voltage-Gated Cation Channels in Neuropathic Pain and Their Potential as Therapeutic Targets. Front Pain Res (Lausanne). 2021 Dec 13;2:750583. doi: 10.3389/fpain.2021.750583.
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