CAS: 163253-37-0; Sitafloxacin Hydrate

英文名称Sitafloxacin Hydrate
中文名称西他沙星水合物
IUPAC名称7-((S)-7-amino-5-azaspiro[2.4]heptan-5-yl)-8-chloro-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrate
其它别名3-Quinolinecarboxylic Acid, 7-[(7S)-7-Amino-5-Azaspiro[2.4]Hept-5-Yl]-8-Chloro-6-Fluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo-, Hydrate; Sitafloxacin (Monohydrate); 3-Quinolinecarboxylic Acid, 7-[(7S)-7-Amino-5-Azaspiro[2.4]Hept-5-Yl]-8-Chloro-6-Fluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo-, Hydrate (1:1); 7-[(7S)-7-Amino-5-Azaspiro[2.4]Hept-5-Yl]-8-Chloro-6-Fluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid Hydrate (1:1); 7-[(7S)-7-Amino-5-Azaspiro[2.4]Hept-5-Yl]-8-Chloro-6-Fluoro-1-[(1R,2S)-2-Fluoro-Cyclopropyl]-1,4-Dihydro-4-Oxo-Quinolin-3-Carboxylic Acid Hydrate
CAS编号163253-37-0
MFCD编号:MFCD11046360
FDA UNII编号:45IP57B62B
分子式:C19H20ClF2N3O4分子量:427.83
产品CID: 827936
产品分类原料药 → 人工合成抗感染类药 → 喹诺酮类药

相似结构搜索
InChIKey: ANCJYRJLOUSQBW-JJZGMWGRSA-N
InChI=1S/C19H18ClF2N3O3.H2O/c20-14-15-8(17(26)9(18(27)28)5-25(15)12-4-10(12)21)3-11(22)16(14)24-6-13(23)19(7-24)1-2-19;/h3,5,10,12-13H,1-2,4,6-7,23H2,(H,27,28);1H2/t10-,1
计算化学: 氢键受体数9.0氢键供体数3.0可旋转键数3.0

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2903919090-氯苯
2905110000-甲醇
2912110000-甲醛
2915110000-甲酸
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专利信息

专利号:US-10358417-B2
优先权日:2016-05-06
标题 :Method for preparing efficiently synthetic sitafloxacin intermediate (7S)-5-azaspiro[2.4]heptane-7-yl tert-butyl carbamate
发明人：LAI YINGJIE; YE DABING; LANG FENGRUI; LONG XIANGTIAN
权利人:CHEN STONE GUANGZHOU CO LTD
摘要:The present invention discloses a preparation method for efficient synthesis of sitafloxacin intermediate (7S)-5-azaspiro[2.4]heptane-7-yl-tert-butyl carbamate, comprising the following steps: reacting n nto obtainn n nreactingn n nto obtainn n nreactingn n nto obtainn n nand reactingn n nto obtainn n nIn the present invention, a single compound with a relatively high ee value can be obtained, the unnecessary waste of materials is avoided, the yield is significantly improved, the operation is simple, the industrial scale-up is easy, and the production cost is reduced.

专利号:US-11382882-B2
优先权日:2010-03-08
标题 :Anti-virulence compositions and methods
发明人：SHOHAM MENACHEM
权利人:UNIV CASE WESTERN RESERVE
摘要:A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.

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合成参考文献

参考文献:10.1007/s10096-011-1326-7
摘要:Tatano Y, Sano C, Yasumoto K, Shimizu T, Sato K, Nishimori K, Matsumoto T, Yano S, Takeyama H, Tomioka H. Correlation between variable-number tandem-repeat-based genotypes and drug susceptibility in Mycobacterium avium isolates. European Journal of Clinical Microbiology & Infectious Diseases. 2011 Jul 12;31(4):445–54. doi: 10.1007/s10096-011-1326-7.