CAS: 142-59-6; Spring-Bak

该化合物是一种合成的非类静态雌激素,历来用于医药,特别是激素替代疗法和防止妊娠并发症.二乙基二乙基溴的特点是能够与雌激素受体结合,模仿体内自然雌激素的影响.该化合物是一种白色晶状固体,在水中溶解不力,但在有机溶剂中可溶解.由于其雌激素活动,它与各种健康风险有关,包括某些癌症和生殖问题的风险增加,导致其退出市场,用于大多数用途.此外,还研究了二乙基乙基溴的持久性和潜在的内分泌干扰效应.其遗留影响着围绕荷尔蒙疗法和药物合成化合物安全的讨论.

结构式图片

欧盟法规

统一分类与标签ECHA物质工作场所安全标识要求ECHA物质C&L通报REACH预注册废弃物危险特性清单

上下游产品

carbon disulfide ethylenediamine ethoxylated pentaerythitol tetraacrylate5,5'-bis-(4-chloro-phenyl)-3,3'-ethane-1,2-diyl-bis-[1,3,5]thiadiazinane-2-thione 5,5'-dibenzyl-3,3'-ethane-1,2-diyl-bis-[1,3,5]thiadiazinane-2-thione bis(tetraphenylphosphonium) ethylenebis(dithi°Carbamate)

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    海关参考信息

    专利信息


    专利号:WO-2025056767-A1
    优先权日:2023-09-15
    标题 :Process for the preparation of enantiomerically enriched aliphatic amines
    发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

    专利号:US-2023212425-A1
    优先权日:2021-02-23
    标 题 :Steel Protective Coating Compositions, Methods of Their Manufacture, and Methods of Their Use
    发明人:WINTERS JONATHAN KERRY; EPSTEIN JAMES
    权利人:Thor Custom Steel Coatings LLC
    摘要:Steel sheet coating compositions in which polymeric resin or ceramic properties are produced by admixing an aluminum coordinate complex and an anhydrous, encapsulated, aluminum particle paste, a polysilazane as a source of silicon, an organic solvent, an organic synthesis catalyst, and optionally a non-metallic, non-ionic, low-nucleophilic base. The admixed coating is applied to sheet steel prior to hot-stamping in order to inhibit surface formation of iron oxides and to improve steel sheet surface characteristics.

    专利号:WO-2021074309-A1
    优先权日:2019-10-16
    标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens
    发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)

    专利号:WO-2021074311-A1
    优先权日:2019-10-16
    标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens
    发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)

    专利号:US-10278395-B2
    优先权日:2013-03-11
    标 题 :Functionalized environmentally benign nanoparticles
    发明人:VELEV ORLIN D; RICHTER ALEXANDER P
    权利人:UNIV NORTH CAROLINA STATE
    摘要:This invention is directed to the preparation and applications of internally and/or externally functionalized environmentally benign nanoparticles (EbNPs), which are produced by a three step procedure: (1) synthesis of native EbNPs, (2) functionalization with active agents, and (3) additional surface property customization via one or more modifier(s).

    专利号:WO-2024177636-A1
    优先权日:2023-02-23
    标题:Improved steel protective coating compositions, methods of their manufacture, and methods of their use
    发明人:WINTERS JONATHAN KERRY; EPSTEIN JAMES
    权利人:Thor Custom Steel Coatings LLC
    摘要:Steel sheet coating compositions in which polymeric resin or ceramic properties are produced by admixing an aluminum coordinate complex and an anhydrous, encapsulated, aluminum particle paste, a polysilazane as a source of silicon, an organic solvent, an organic synthesis catalyst, and optionally a non-metallic, non-ionic, low-nucleophilic base. The admixed coating is applied to sheet steel prior to hot-stamping in order to inhibit surface formation of iron oxides and to improve steel sheet surface characteristics.

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    主要参考文献


    1: Anderson CC, Marentette JO, Rauniyar AK, Prutton KM, Khatri M, Matheson C, Reisz JA, Reigan P, D'Alessandro A, Roede JR. Maneb alters central carbon metabolism and thiol redox status in a toxicant model of Parkinson's disease. Free Radic Biol Med. 2021 Jan;162:65-76. doi: 10.1016/j.freeradbiomed.2020.11.028. Epub 2020 Dec 3.
    2: Hoffman L, Trombetta L, Hardej D. Ethylene bisdithiocarbamate pesticides Maneb and Mancozeb cause metal overload in human colon cells. Environ Toxicol Pharmacol. 2016 Jan;41:78-88. doi: 10.1016/j.etap.2015.11.002. Epub 2015 Nov 7. 30(7):1287-98. doi: 10.1080/19440049.2013.801083. Epub 2013 Jun 25. 34(5):324-9. doi: 10.1111/j.1600-0536.1996.tb02216.x. 74(2):384-8. 15(6):313-37. doi: 10.1002/(SICI)1520-6866(1996)15:6<313::AID- TCM7>3.0.CO;2-L.

    合成参考文献


    摘要:Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel, Perkow, W., Berlin, Verlag Paul Parey, 1971-1976, -(-), 1971/1976
    摘要:Menzie, C.M. Metabolism of Pesticides-Update III. Special Scientific Report- Wildlife No. 232. Washington, DC: U.S.Department of the Interior, Fish and Wildlife Service, 1980., p. 269
    摘要:Tomlin, C.D.S. (ed.). The Pesticide Manual - World Compendium. 10th ed. Surrey, UK: The British Crop Protection Council, 1994., p. 714
    摘要:USEPA/Office of Pesticide Programs; Reregistration Eligibility Decision Document - Nabam p.8 EPA 738-R-95-035 (January 1996). Available from, as of March 8, 2010:
    摘要:USEPA/Office of Pesticide Programs; Reregistration Eligibility Decision Document - Nabam p.v EPA 738-R-95-035 (January 1996). Available from, as of March 4, 2010: https://www.epa.gov/pesticides/reregistration/status.htm
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