CAS: 1244-58-2; Cannabidiolic Acid

上下游产品

geranyl diphosphate 2,4-dihydroxyl-6-pentylbenzoic acid CBGA OlivetolHU-331 -cyclohexen-(2)-yl)-1.4-benz°Chinoyl-(2)>Bis-3-n-amyl-5-hydroxy-6-(trans-3-methyl-6--cyclohexen-(2)-yl)-1.4-benz°Chinoyl-(2) CBD dronabinol

📜2,4-二羟基-6-戊基苯甲酸甲酯置于sodiumsulfide Nonahydrate,三氟化硼乙醚体系中,用 N,N-二甲基甲酰胺,氯苯 用作溶剂,化学反应 25.0H,反应生成大麻二醇酸
参考文献: Synthesis Of Phytocannabinoids Including A Demethylation Step[fr] Synthèse De Phytocannabinoïdes Comprenant Une étape De Déméthylation
标题: Synthesis Of Phytocannabinoids Including A Demethylation Step[fr] Synthèse De Phytocannabinoïdes Comprenant Une étape De Déméthylation
摘要:一种去甲基化甲基化植物大麻化合物的方法,形成化学式ii的植物大麻化合物:化学式i 化学式ii 其中:R1选择自:取代或未取代的c1-C5烷基;R2选择自:Oh或o,并且r3选择自:取代或未取代的环己烯,取代或未取代的c2-C8烯烃,或取代或未取代的c2-C8双烯;或者r2为o,且r2和r3一起形成一个环结构,其中r2为内环原子;其中该方法包括:在存在溶解的无机碱性盐的极性无水溶剂中加热反应混合物,以足够时间去甲基化至少一部分甲基化植物大麻化合物并形成植物大麻化合物.

专利信息

专利号:WO-2025217205-A1
优先权日:2024-04-08
标 题:Synthesis of (-)-trans-δ9-tetrahydrocannabivarin (δ9-thcv) and analogs thereof
发明人：HAGHDOOST MEHDI; ROBERTS MATTHEW; THOMAS BRIAN; DICKINSON LUKE; NIKITIN EDWARD
权利人:NALU BIO INC
摘要:A method is provided for the synthesis of (-)-trans-Δ9-tetrahydrocannabivarin (Δ9-THCV) and analogs thereof such that in the reaction product, the molar ratio of the Δ9 isomer to incidentally formed Δ8 isomers is greater than 4:1. Synthesis is carried out by combining a selected cannabinoid reactant, e.g., cannabidivarin (CBDV) or an analog thereof, with an acid in a solvent for the cannabinoid reactant, wherein the acid comprises (i) a Lewis acid having an acid softness index value in the range of -10 ΔG0 f, M n+ to ‑150 ΔG0 f, M n+, (ii) a Brønsted acid having a pKa in the range of -4.0 to +4.0, or (iii) a combination of (i) and (ii), under reaction conditions comprising a reaction temperature in the range of ‑0 °C to 25 °C and a reaction time in the range of 1 hour to 24 hours. The reaction is thereafter quenched with base and the solvent removed, wherein the crude reaction product so provided may be purified, e.g., chromatographically purified. Also provided is a method for synthesizing Δ9-THCV that further includes synthesis of the cannabinoid reactant. The invention additionally provides novel cannabinoid compositions that may be synthesized using the aforementioned methodology.

专利号:US-2024228455-A1
优先权日:2021-04-27
标 题 :Synthesis of cbn and cbnv
发明人：KAVARANA MALCOLM J
权利人:TEEWINOT LIFE SCIENCES CORP
摘要:The invention includes chemical synthesis for preparing cannabinol (CBN) and cannabinovarin (CBNV). The process is suitable for inter alia the large-scale synthesis of pharmaceutical grade CBN and CBNV.

专利号:US-11046978-B2
优先权日:2016-03-16
标 题:Synthesis of isoprenoids and derivatives
发明人：GONZALEZ RAMON; CLOMBURG JAMES M; CHEONG SEOKJUNG
权利人:UNIV RICE WILLIAM M
摘要:This disclosure generally relates to the use of enzyme combinations or recombinant microbes comprising same to make isoprenoid precursors, isoprenoids and derivatives thereof including prenylated aromatic compounds. Novel metabolic pathways exploiting Claisen, aldol, and acyioin condensations are used instead of the natural mevalonate (MVA) pathway or 1-deoxy-d-xylulose 5-phosphate (DXP) pathways for generating isoprenoid precursors such as isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), and geranyl pyrophosphate (GPP). These pathways have the potential for better carbon and or energy efficiency than native pathways. Both decarboxylative and non-carboxylative condensations are utilized, enabling product synthesis from a number of different starting compounds. These condensation reactions serve as a platform for the synthesis of isoprenoid precursors when utilized in combination with a variety of metabolic pathways and enzymes for carbon rearrangement and the addition/removal of functional groups. Isoprenoid alcohols are key intermediary products for the production of isoprenoid precursors in these novel synthetic metabolic pathways.

专利号:US-11466283-B2
优先权日:2016-08-18
标 题:Plants and methods for increasing and decreasing synthesis of cannabinoids
发明人：ROSCOW ROBERT F
权利人:CANOPY GROWTH CORP
摘要:This disclosure relates to new plants and methods for increasing and decreasing synthesis of cannabinoids. The plants disclosed herein comprise unnatural ratios and concentrations of cannabinoids in plants of genus Cannabis . The methods disclosed herein comprise manipulating the biosynthetic pathway of cannabinoids to produce plants of genus Cannabis with unnatural ratios and concentrations of cannabinoids.

专利号:WO-2024208875-A1
优先权日:2023-04-03
标题:Organic reinforcement of a polyamide with the in situ synthesis of a polyimide phase by reactive extrusion
发明人：CASSAGNAU PHILIPPE; DELAGE KARIM; BOUNOR-LEGARE VÉRONIQUE; MARESTIN CATHERINE; DUBOIS CHARLOTTE; GAROIS NICOLAS
权利人:TOTALENERGIES ONETECH; UNIV CLAUDE BERNARD LYON 1 UCBL; CENTRE NAT RECH SCIENT; UNIV JEAN MONNET SAINT ETIENNE UJM; INSTITUT NAT DES SCIENCES APPLIQUEES DE LYON INSA LYON
摘要:The disclosure relates to a reinforced polyamide and to a process to produce a reinforced polyamide comprising providing components being one or more polyamides, one or more dianhydrides, and one or more diamines; wherein the one or more polyamides are provided at a content of at least 60 wt.% based on the total weight of the components and wherein the one or more polyamides comprise at least one polyamide having amide groups separated by at least 10 CH2 groups; performing in situ synthesis of a polyimide by reactive extrusion of the components wherein the residence time is less than 10 minutes; and recovering a polyamide-polyimide blend being a reinforced polyamide comprising a continuous polyamide phase and a polyimide dispersed phase.

专利号:WO-2024170663-A1
优先权日:2023-02-15
标 题:Organic reinforcement of an elastomer with the in situ synthesis of a polyimide phase by reactive extrusion
发明人：CASSAGNAU PHILIPPE; DELAGE KARIM; BOUNOR-LEGARE VÉRONIQUE; MARESTIN CATHERINE; DUBOIS CHARLOTTE; GAROIS NICOLAS
权利人:TOTALENERGIES ONETECH; UNIV CLAUDE BERNARD LYON 1 UCBL; CENTRE NAT RECH SCIENT; UNIV JEAN MONNET SAINT ETIENNE; INSTITUT NAT DES SCIENCES APPLIQUEES DE LYON INSA LYON
摘要:The present disclosure relates to a process to produce a reinforced elastomeric material and to the reinforced elastomeric material. The process comprises the steps of providing components comprising a grafted elastomer, one or more dianhydrides, and one or more diamines; wherein the grafted elastomer is provided at a content of at least 60 wt.% based on the total weight of the components; performing in situ synthesis of a polyimide phase in the grafted elastomer by reactive extrusion of the components in a twin-screw extruder comprising main hopper wherein the screw profile comprises two or more reverse conveying elements forming two or more hot zones to form an elastomer-polyimide blend; and recovering said elastomer-polyimide blend being a reinforced elastomeric material.