CAS: 116-45-0; 4-Amino-N-(5-Bromo-4,6-Dimethylpyrimidin-2-yl)Benzenesulfonamide

📜2-氨基-5-溴-4,6-二甲基嘧啶,对乙酰胺基苯磺酰氯置于吡啶体系中,化学反应生成磺胺溴二甲嘧啶
参考文献:化疗研究;抗疟药 卤代磺酰胺基杂环.
标题:化疗研究;抗疟药 卤代磺酰胺基杂环.
摘要:
Doi:10.1021/ja01207A033

专利信息

专利号:US-9439423-B2
优先权日:2007-10-29
标 题 :Antiparasitic agent for fish and method of controlling proliferation of fish parasites
发明人：KAWANO FUMI; HIRAZAWA NORITAKA
权利人:KAWANO FUMI; HIRAZAWA NORITAKA; NIPPON SUISAN KAISHA LTD
摘要:An antiparasitic agent for fish includes an inhibitor of folate synthesis and/or an inhibitor of folate activation as the active substance(s). A combination preparation composed of an inhibitor of folate synthesis and an inhibitor of folate activation is disclosed. Sulfonamide is disclosed as suitable for the inhibitor of folate synthesis. A dihydrofolate reductase inhibitor, a folate antagonist are disclosed as suitable inhibitors of folate activation. The antiparasitic agent is able to exterminate fish parasites via oral administration. It is effective against fish parasites belonging to the ciliate group.

专利号:US-9265777-B2
优先权日:2009-04-27
标题 :Antiparasitic agent for fish and method of controlling proliferation of fish parasites
发明人：KAWANO FUMI; HIRAZAWA NORITAKA
权利人:KAWANO FUMI; HIRAZAWA NORITAKA; NIPPON SUISAN KAISHA LTD
摘要:A method of controlling proliferation of fish parasites comprising the administration of 1 to 50 mg/kg fish body weight/day of an inhibitor of folate synthesis and/or an inhibitor of folate activation to fish continuously for 1 to 2 weeks. Using a combination preparation composed of an inhibitor of folate synthesis and an inhibitor of folate activation is preferable, and a sulfonamide is preferable for the inhibitor of folate synthesis. A dihydrofolate reductase inhibitor, a folate antagonist, etc., can be used as the inhibitor of folate activation. The antiparasitic agent is able to exterminate fish parasites via oral administration. It is particularly effective against parasites belonging to the ciliate group among fish parasites.

专利号:US-2023398101-A1
优先权日:2022-06-09
标题 :Co-agents as Therapy Against Anaerobic Pathogens
发明人：PACE JOHN LEE; HARTSELL THERESA LYNN
权利人:FLEURIR ABX LLC
摘要:Co-agent combinations and/or formulations herein unexpectedly display significantly better antimicrobial activity (e.g., more efficacy and/or more potency) against anaerobic pathogens not previously considered targets. With three or more co-agents, selected from a group of a fosfomycin, a diaminopyridine, a sulfonamide, a beta lactam antibacterial, a bacterial beta-lactamase inhibitor, a bacterial fosfomycin-modifying enzyme, and a bacterial peptidoglycan synthesis inhibitor, the therapeutic potential of the three or more co-agents is expanded by targeting a broader spectrum of pathogens. Co-agents, by unexpected synergistic action in an anaerobic environment, are now active and efficacious against difficult to treat pathogenic anaerobes (including anaerobes that cannot utilize oxygen and/or reside in an anaerobic environment, some being inhibited by oxygen), as well as pathogens considered resistant or intolerant to at least one of the co-agents when used singly in an anaerobic environment. Some co-agent combinations and/or formulations contain one or more existing antibiotic agents being repurposed for utility against difficult to treat anaerobic pathogens.

专利号:TW-I429397-B
优先权日:2009-04-27
标题:Use of a composition containing a folic acid synthesis inhibitor and/or a folic acid activation inhibitor

专利号:CN-110028457-A
优先权日:2019-05-24
标题:A kind of stable isotope-labeled sulfa bromide and its synthesis method