CAS: 107149-56-4; Diethylisopropylsilylchloride

相似化合物

994-30-9 13154-24-0 18162-48-6

上下游产品

1,1,1-trichloro-2-methyl-1-silapropane ethyllithium isopropyl chloride diethyldichlorosilanediethyl(isopropyl)silyl trifluoromethanesulfonate (2S,3R)-2-[1-(Diethyl-isopropyl-silanyloxy)-2-(4-methoxycarbonyl-2-methoxymethoxy-6-nitro-phenyl)-ethyl]-3-(4-methoxy-benzyloxymethyl)-aziridine-1-carboxylic acid methyl ester methyl (2R,3S)-2-((4-methoxybenzyloxy)methyl)-3-(1R-(diethyl(isopropyl)silyloxy)-2-(2,3,5-trimethoxy-4-methyl-6-nitrophenyl)ethyl)aziridine-1-carboxylate 31H42O8SSiC31H42O8SSi

📜异丙基三氯硅烷,乙基锂 以 四氢呋喃,乙醚 用作溶剂,化学反应 18.0H,反应生成二乙基异丙基氯硅烷
参考文献:Steroidal Silicon Side-Chain Analogs As Potential Antifertility Agents
标题:Steroidal Silicon Side-Chain Analogs As Potential Antifertility Agents
摘要:A Number Of Silicon-Substituted Analogues Of Ethynylestradiol That Exhibit Modified And Enhanced Biological Activities Have Been Synthesized. Particularly Noteworthy Are A Group Of [(Trialkylsilyl)Ethynyl]Estradiol Analogues That Exhibit High Antifertility Potency And Markedly Reduced Estrogenic Activity. The Best Compounds Synthesized Are 17 Alpha-[(Triethylsilyl)Ethynyl]Estradiol (5) And 17 Alpha-[(Tert-Butyldimethylsilyl)Ethynyl]Estradiol (33),Which Show A Separation Of Antifertility From Estrogenic Activity In The Rat. The Results Of Structure-Activity Studies Indicate A Good Correlation Between The Observed Biological Activities And The Calculated Van Der Waals Volumes Of The Three Variable Silicon Substituents.
Doi:10.1021/jm00387A011

专利信息

专利号:US-7342003-B2
优先权日:2001-10-25
标 题 :Synthesis of 2-aralkyloxyadenosines, 2-alkoxyadenosines, and their analogs
发明人：MOORMAN ALLAN R; SCANNELL MICHAEL; BALASUBRAMANIAN THIAGARAJAN; OUTCALT RUSSELL; LEUNG EDWARD
权利人:KING PHARMACEUTICALS RES & DEV
摘要:Provided is a method for the synthesis of an aralkyloxyadenosine or an alkoxyadenosine. The method includes protecting the hydroxyl sugar groups with a protecting group to produce a protected halogenated adenosine. The protected halogenated adenosine is alkoxylated, and the hydroxyl sugar groups of the protected halogenated adenosine are deprotected to provide the aralkyloxyadenosine or alkoxyadenosine.

专利号:US-7884128-B2
优先权日:2005-10-13
标题:Process for total synthesis of pladienolide B and pladienolide D
发明人：KANADA REGINA MIKIE; ITO DAISUKE; SAKAI TAKASHI; ASAI NAOKI; KOTAKE YOSHIHIKO; NIIJIMA JUN
权利人:EISAI R&D MAN CO LTD
摘要:Process for producing compound of Formula: n nwherein P 2 , P 3 and R 2 are the same as defined below, characterized by comprising reacting a compound represented by Formula (7):n n nwherein P 3 means a protecting group for hydroxy group; and Het means a 1-phenyl-1H-tetrazol-5-yl group, with a compound represented by Formula (8):n n nwherein P 2 means a protecting group for hydroxy group; and R 2 means a phenyl group which may be substituted, in the presence of a base.

专利号:US-12415828-B2
优先权日:2014-08-22
标题:Modified oligonucleotides and methods for their synthesis
发明人：STETSENKO DMITRY; KUPRYUSHKIN MAXIM; PYSHNYI DMITRII
权利人:NOOGEN LLC
摘要:Modified oligonucleotides that contain one or more of the phosphate groups substituted at phosphorus and methods for their synthesis are disclosed.

专利号:US-2006135466-A1
优先权日:2001-10-25
标题 :Synthesis of 2-aralkyloxyadenosines, 2-alkoxyadenosines, and their analogs

专利号:US-4684724-A
优先权日:1981-12-25
标题:4-Cyano-2-azetidinones and production thereof
发明人：OCHIAI MICHIHIKO; KISHIMOTO SHOJI; MATSUO TAISUKE
权利人:TAKEDA CHEMICAL INDUSTRIES LTD
摘要:4-Cyano-2-azetidinone derivatives represented by the formula ##STR1## wherein R 1 is an amino group which may be acylated or protected, X is a hydrogen atom or a methoxy group and W is a hydrogen atom or a sulfo group, and methods of producing the same, for example, as represented by ##STR2## wherein R 2 is an acylated or protected amino group, Y is a halogen atom or a group having the formula --OCOR 3 , --SCOR 3 or --S(O) n --R 3 (R 3 being a hydrocarbyl group and n an integer 1 or 2), R 4 is an amino group which may be acylated or protected and X is as defined above. Compounds [I] are useful as advantageous intermediates for the synthesis of optically active 4-substituted-2-azetidinone derivatives, and, when W=SO 3 H, [I] are also useful as antimicrobial agents and as beta-lactamase inhibitors.

专利号:US-2008021226-A1
优先权日:2005-10-13
标题:Process for total synthesis of pladienolide B and pladienolide D