专利号:US-7527712-B2 优先权日:2002-07-23 标 题 :Method for the continuous purification by distillation of the solvent methanol, used in the synthesis of propylene oxide 发明人:BASSLER PETER; GOEBBEL HANS-GEORG; TELES JOAQUIM HENRIQUE; RUDOLF PETER 权利人:BASF AG 摘要:Process for the continuously operated purification by distillation of the methanol used as solvent in the synthesis of propylene oxide by reaction of a hydroperoxide with propylene, with the methoxypropanols being separated off simultaneously, wherein the solvent mixture obtained in the synthesis is separated in a dividing wall column into a low-boiling fraction including methanol, an intermediate-boiling fraction containing the methoxypropanols as azeotrope with water and a high-boiling fraction including water and propylene glycol.
专利号:US-2005252762-A1 优先权日:2002-07-23 标 题:Method for the continuous purification by distillation of methanol, used as a solvent in the synthesis of propylene oxide without coupling products, with the simultaneous isolation of the methoxy propanols 发明人:BASSLER PETER; GOBBEL HANS-GEORG; TELES JOAQUIM H; RUDOLF PETER 权利人:BASF AG 摘要:Continuously operated process for the purification by distillation of the methanol used as solvent in the synthesis of propylene oxide by reaction of a hydroperoxide with propylene, with the methoxypropanols, as azcotrope with water, and the low boilers and high boilers simultaneously being separated off, wherein the solvent mixture obtained in the synthesis is fractionated in a dividing wall column.
专利号:US-4939112-A 优先权日:1988-10-06 标 题:Catalyst for synthesis of vesicular phenoxy resins 发明人:BENNETT EVERETT W 权利人:JAMES RIVER PAPER CO 摘要:A catalyst for synthesis of vesicular phenoxy resins is disclosed. The catalyst includes a water-insoluble complex of a hydric phenol and a quaternary ammonium or phosphonium salt of the hydric phenol. Preferably, the hydric phenol is an intermediate of the phenoxy resin being produced. Dihydric phenols, such as sulfonyldiphenol are preferred. The invention further relates to a reaction medium for polymerization of phenoxy resins including the above-described catalyst and a solvent medium capable of dissolving the phenoxy resins and otherwise not interfering with the polymerization reaction. The solvent medium is advantageously free of toxic Methyl Cellosolve.
专利号:US-2010191010-A1 优先权日:2007-07-02 标题 :Process for the synthesis of carbamates using co2 发明人:BOSMAN JORIS KAREL PETER; CARR ROBERT HENRY 权利人:HUNTSMAN INT LLC 摘要:Process for the synthesis of non cyclic carbamate derivatives from amine compounds, alcohols and CO 2 in the presence of ionic liquids and optionally in the presence of a base.
专利号:US-8962887-B2 优先权日:2009-07-21 标题 :Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol 发明人:HOMESTAD OLE MAGNE 权利人:HOMESTAD OLE MAGNE; GE HEALTHCARE AS 摘要:This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerization of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with a solvent mixture comprising 1-methoxy-2-propanol and water or methanol.
专利号:WO-2024256322-A1 优先权日:2023-06-13 标题 :Synthesis of non-ionic radiographic contrast agents by means of reactive extrusion 发明人:LATTUADA LUCIANO; SEBASTIANO ROBERTO; LEONARDI GABRIELLA; CRAVOTTO GIANCARLO; BARGE ALESSANDRO; BUCCIOL FABIO 权利人:BRACCO IMAGING SPA; MILANO POLITECNICO 摘要:The present invention relates to the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a process for the synthesis of lopamidol using a reactive extrusion process in continuous which enable an efficient conversion of the relevant key intermediates, preferably in the absence of any solvent. The invention further relates to the preparation of radiographic X-rays contrast agents or key intermediates thereof by exploiting the technology of reactive extrusion.
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合成参考文献
参考文献:10.1007/s00216-010-3487-0 摘要:Tomicic C, Berode M. Sensitive headspace gas chromatography analysis of free and conjugated 1-methoxy-2-propanol in urine. Analytical and Bioanalytical Chemistry. 2010 Feb 13;396(7):2709–14. doi: 10.1007/s00216-010-3487-0.