CAS: 96-15-1; 2-Methylbutylamine

该化合物是一种有机化合物,被归类为一种矿物质,是一种手性分子,以两种对应形式存在,可以显示不同的生物活动;该化合物具有分链结构,其特点是五碳脊柱,与第二个碳相连的一组甲基;典型的是一种无色黄色的黄色液体,具有一种独特的矿味;2-甲基丁基胺在水和有机溶剂中溶解,使其具有多种用途,可应用于有机合成以及生产药品和农用化学品.该矿功能组的存在具有基本特性,允许其参与各种化学反应,例如变形和细胞反应.安全考虑包括它有可能引起皮肤或眼睛接触时的刺激,以及应当采取适当的处理措施以尽量减少接触.

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CAS号137-32-6 2-甲基丁醇 | CAS号106-98-9 正丁烯 | CAS号201230-82-2 carbon monoxide | CAS号73-32-5 L-异亮氨酸 | CAS号61892-69-1 3-methylpentanamide | CAS号4403-61-6 2-甲基-2-丁烯腈 | CAS号100-10-7 对二甲氨基苯甲醛 | CAS号107-12-0 丙腈 | CAS号319-78-8 D-异亮氨酸 | CAS号1565-80-6 S(-)-2-甲基-1-丁醇 | CAS号1011-92-3 α-氰基肉桂酸 | CAS号102-96-5 β-硝基苯乙烯 | CAS号1646-99-7 2-Methylbutanal... | CAS号4440-16-8 Malonic acid, f... | CAS号54449-43-3 N-(2-methylbuty... | CAS号95-14-7 苯并三氮唑 | CAS号14618-17-8 Acetamide, 2,2,...

合成工艺路线路线简述

  • 合成目标产物 2-Methylbutylamine 主要起始原料 2-Methyl-1-Butanol
  • 96-17-3 = 96-15-1
    反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Cobalt,Graphene Solvents: Methanol; 4 H,2 Mpa,90 °C
    标题:A General Synthesis Of Amines Via Cobalt Atoms Individually Anchored By Divacancy Sites On Graphene-Shelled Layers
    作者:Zhuang,Xiuzheng; Liu,Jianguo; Ji,Yangqi; Wu,Xiaojun; Zhang,Xinghua; Et Al
    参考文献:Chem Catalysis 日期:2023 卷标:3(8)]

    = 96-15-1
    反应条件:1.1 Reagents: Ammonia Catalysts: (Oc-6-52)-[4,5-Bis[[bis(1-Methylethyl)Phosphino-Kp]Methyl]Acridine-Kn]Carbonylch... Solvents: Toluene; 18 H,7.5 Atm,Reflux
    标题:Preparation Of Ruthenium Complexes With Quinolinyl Or Acridinyl Based Pincer Ligands For Use As Catalysts In The Process For Preparing Amines From Alcohols And Ammonia
    参考文献:World Intellectual Property Organization]

    94905-02-9 = 96-15-1
    反应条件:1.1 Reagents: Hydrogen
    标题:Reactions Of Unsaturated Alkyl Azides. Part 1. Synthesis And Reactions Of 4-Azido-3-Methyl-1,2-Butadiene
    作者:Banert,K.
    参考文献:Angewandte Chemie 日期:1985 卷标:97(3) 页码:231-2]

    = 96-15-1 [标题:Reaction Conditions
    标题:Drugs Composed Of ω-Polyunsaturated Fatty Amides Or Esters With Biogenic Amines Or Alcohols
    参考文献:European Patent Organization]

    = 96-15-1 [标题:Reaction Conditions
    标题:N-Indanyl-4-Aminosulfonylbenzamides As Potassium Channel Blockers
    参考文献:Germany]

    = 96-15-1 [标题:Reaction Conditions
    标题:Alkylation Of Ammonia By Aliphatic Alcohols Under Hydrogen Pressure
    作者:Bel'Chev,F. V.
    参考文献:Trudy Belorusskoi Sel'Skokhozyaistvennoi Akademii 日期:1968 卷标:42 页码:232-8]

    = 96-15-1 [标题:Reaction Conditions
    标题:Amines
    参考文献:United States]

    116-53-0 = 96-15-1 + 1113-57-1 + 27094-65-1
    反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Aluminum Magnesium Oxide (Al2Mgo4),Ruthenium Tungsten Oxide Solvents: Cyclopentyl Methyl Ether; 6 Bar,Rt -> 200 °C; 6.5 H,50 Bar,200 °C
    标题:One-Pot Reductive Amination Of Carboxylic Acids: A Sustainable Method For Primary Amine Synthesis
    作者:Coeck,Robin; De Vos,Dirk E.
    参考文献:Green Chemistry 日期:2020 卷标:22(15) 页码:5105-5114]

    96-17-3 = 96-15-1
    反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Nickel Monoxide (On Graphene),Nickel (On Graphene) Solvents: Methanol; 4 H,2 Mpa,90 °C
    标题:Method For Preparing Primary Amine Through Catalytic Reducing Amination Of Aldehyde/ketone Compound
    参考文献:China]

    96-17-3 = 96-15-1
    反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Nickel Monoxide,Nickel,Carbon Solvents: Methanol; 4 H,2 Mpa,90 °C
    标题:Facile Synthesis Of Controllable Graphene-Co-Shelled Reusable Ni/nio Nanoparticles And Their Application In The Synthesis Of Amines Under Mild Conditions
    作者:Liu,Jianguo; Zhu,Yuting; Wang,Chenguang; Singh,Thishana; Wang,Nan; Et Al
    参考文献:Green Chemistry 日期:2020 卷标:22(21) 页码:7387-7397]

    73-32-5 = 96-15-1
    反应条件:1.1 Reagents: Hydrogen Catalysts: Titania,Ruthenium Trichloride Trihydrate Solvents: Water; 8 Mpa,Rt; 4 H,180 °C
    标题:One-Step Preparation Method Of 2-Methylbutylamine By Decarboxylating L-Isoleucine
    参考文献:China]

    = 96-15-1
    反应条件:1.1 Reagents: Ammonia Catalysts: Nickel Solvents: 2-Methyl-2-Butanol; 18 H,7 Bar,170 °C
    标题:Primary Amines From Lignocellulose By Direct Amination Of Alcohol Intermediates,Catalyzed By Raney Ni
    作者:Wu,Xianyuan; De Bruyn,Mario; Barta,Katalin
    参考文献:Catalysis Science & Technology 日期:2022 卷标:12(19) 页码:5908-5916]

    = 96-15-1
    反应条件:1.1 Reagents: Ammonia Catalysts: (Oc-6-52)-[4,5-Bis[[bis(1-Methylethyl)Phosphino-Kp]Methyl]Acridine-Kn]Carbonylch... Solvents: Toluene; 18 H,7.5 Atm,Reflux
    标题:Selective Synthesis Of Primary Amines Directly From Alcohols And Ammonia
    作者:Gunanathan,Chidambaram; Milstein,David
    参考文献:Angewandte Chemie 日期:2008 卷标:47(45) 页码:8661-8664]

    96-17-3 = 96-15-1
    反应条件:1.1 Catalysts: Nadh Solvents: Water; 4 H,Ph 9.5,25 °C
    标题:Enzymic Preparation Of Chiral Amines From Aldehydes And Ketones Catalyzed By Microbial Dihydrodipicolinate Reductases
    参考文献:World Intellectual Property Organization]

    96-17-3 = 96-15-1
    反应条件:1.1 Reagents: Formaldehyde1.2 -
    标题:Method For Producing 2-Methylbutanal From The Secondary Flows Arising In The Production Of Mixtures Of Isomeric α,β-Unsaturated Decenals
    参考文献:Germany]

    = 96-15-1 [标题:Reaction Conditions
    标题:Preparation Of Benzamide Derivatives For Controlling Plant Diseases
    参考文献:World Intellectual Property Organization]

    = 96-15-1 [标题:Reaction Conditions
    标题:The Peptoid Synthesis From Some Amino Acid Analogs
    作者:Logoglu,E.
    参考文献:Communications De La Faculte Des Sciences De L'Universite D'Ankara 日期:2004 卷标:50(2) 页码:17-22]

    = 96-15-1 [标题:Reaction Conditions
    标题:Synthesis Of New 3'-,5-,And N4-Modified 2'-O-Methylcytidine Libraries On Solid Support
    作者:Ding,Yili; Habib,Qazi; Shaw,Stephanie Z.; Li,David Y.; Abt,Jeffrey W.; Et Al
    参考文献:Journal Of Combinatorial Chemistry 日期:2003 卷标:5(6) 页码:851-859]

    = 96-15-1 + 27094-65-1
    反应条件:1.1 Reagents: Urea,Potassium Carbonate Catalysts: 1,3-Bis(Diphenylphosphino)Propane,Chloro(η5-2,4-Cyclopentadien-1-Yl)[1,1′-(1,2-Ethanediyl)Bis[1,1-Diphenylphosphin... Solvents: Diglyme; 12 H,160 °C
    标题:Amination Of Aliphatic Alcohols With Urea Catalyzed By Ruthenium Complexes: Effect Of Supporting Ligands
    作者:Dindar,Sara; Nemati Kharat,Ali
    参考文献:Journal Of Coordination Chemistry 日期:2020 卷标:73(13) 页码:1954-1966]

    = 96-15-1
    反应条件:1.1 Reagents: Ammonia Catalysts: Di-μ-Chlorobis[(1,2,5,6-η)-1,5-Cyclooctadiene]Dirhodium,Di-μ-Chlorobis[(1,2,5,6-η)-1,5-Cyclooctadiene]Diiridium,[1,1′-Binaphthalene]-4,4′,7,7′-Tetrasulfonic Acid,2,2′-Bis[[bis(3-Sulfophenyl)P... Solvents: Tert-Butyl Methyl Ether,Water1.2 Reagents: Hydrogen
    标题:The First Efficient Hydroaminomethylation With Ammonia: With Dual Metal Catalysts And Two-Phase Catalysis To Primary Amines
    作者:Zimmermann,Burkhard; Herwig,Jurgen; Beller,Matthias
    参考文献:Angewandte Chemie 日期:1999 卷标:38(16) 页码:2372-2375
📜2-甲基-2-丁烯腈置于乙酸酐,铂体系中,化学反应生成 吲哚啉
参考文献:The Reactions Of Cyanogen Chloride. I. Addition To Olefins
标题:The Reactions Of Cyanogen Chloride. I. Addition To Olefins
摘要:
DOI:10.1021/jo01121A003

海关参考信息

专利信息


专利号:WO-9837078-A1
优先权日:1997-02-20
标题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The thiophenes are prepared by reaction of a substrate-bound primary or secondary amine with a thiophosgene equivalent and reaction of the resulting intermediate with an acceptor-substituted acetonitrile in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegler-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:US-7323575-B2
优先权日:2003-04-09
标题:Process for the synthesis of (2S)-indoline-2-carboxylic acid
发明人：SOUVIE JEAN-CLAUDE; LECOUVE JEAN-PIERRE
权利人:SERVIER LAB
摘要:Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): n nApplication in the synthesis of perindopril and its pharmaceutically acceptable salts.

专利号:US-10759743-B2
优先权日:2016-10-24
标 题 :Pd-catalyzed γ-C(sp3)-H arylation / heteroarylation of free amines
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:Pd(II)-catalyzed g-G(sp3)-H arylation or heteroarylation of primary amines is realized by using 2-hydroxynicotinaldehyde as a catalytic transient directing group. Importantly, the catalyst and the directing group loading can be lowered to 2% and 4% respectively, thus demonstrating high efficiency of this newly designed transient directing group. Heterocyclic aryl iodides are also compatible with this reaction. Furthermore, swift synthesis of 1,2,3,4-tetrahydronaphthyridine derivatives is accomplished using this reaction.

专利号:US-2016122450-A1
优先权日:2013-05-08
标题:Synthesis of a substituted furan
发明人：ZHANG YUGEN; TEONG SIEW PING; YI GUANGSHUN
权利人:AGENCY SCIENCE TECH & RES
摘要:The present invention provides a polymer comprising an aliphatic backbone having a plurality of aromatic rings bonded thereon, said plurality of aromatic rings comprising a first aromatic ring type that has an alkyl halide group substitution on the aromatic ring and a second aromatic ring type that has an optionally substituted ammonium halide group substitution on the aromatic ring. The present invention also provides a method for making an optionally substituted furan, the method comprising the step of subjecting a sugar to a dehydration reaction in the presence of a catalyst comprising said polymer.

专利号:US-2016311941-A1
优先权日:2013-12-19
标 题:Process for the preparation of colesevelam
发明人：GABOARDI MAURO; BARUTO ALESSANDRO; CASTALDI MARTA
权利人:CHEMI SPA
摘要:The present invention relates to a new process for the synthesis of Colesevelam, which is used in therapy in cases of hypercholesterolemia due to low density lipoproteins. Said process comprises the reaction, in a basic environment, of polyallylamine with: i) at least one alkylating agent of formula X—(CH 2 ) 9 —CH 3 and at least one alkylating agent of formula Y—(CH 2 ) 6 —N + (CH 3 ) 3 Z − , wherein X and Y are each independently a leaving group, and Z is a halogen; and ii) at least one crosslinking agent. The present invention also relates to the Colesevelam obtainable by the above process.

专利号:WO-9931506-A9
优先权日:1997-12-18
标题:Parallel solution phase synthesis of lactams
发明人：CWI CYNTHIA LYNN; SCOTT WILLIAM LEONARD
权利人:LILLY CO ELI; CWI CYNTHIA LYNN; SCOTT WILLIAM LEONARD
摘要:The present invention provides a parallel solution phase process for making combinatorial arrays of lactam derivatives which are useful for screening for therapeutically useful compounds.

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合成参考文献


摘要:Scammells, P. J., Science of Synthesis Knowledge Updates, (2013) 2, 445.
摘要:N. F. Hall and M. R. Sprinkle. J. Am. Chem. Soc. 54, 3469 (1932).
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