CAS: 956103-76-7; [18F]Florbetapir

上下游产品

(E)-2-[2-[2-[[5-[4-[boc-(甲基)氨基]苯乙烯基]-2-吡啶基]氧基]乙氧基]乙氧基]乙基-4-甲基苯磺酸酯 Av-105 1205550-99-7

📜(E)-2-[2-[2-[[5-[4-[boc-(甲基)氨基]苯乙烯基]-2-吡啶基]氧基]乙氧基]乙氧基]乙基-4-甲基苯磺酸酯置于potassium [18F]Fluoride,盐酸体系中,用 二甲基亚砜,水 作为反应溶剂,化学反应 0.25H,反应生成 氟贝他吡[18F]
参考文献:Preparation And Stability Of Ethanol-Free Solution Of [18F]Florbetapir ([18F]Av-45) For Positron Emission Tomography Amyloid Imaging
标题:Preparation And Stability Of Ethanol-Free Solution Of [18F]Florbetapir ([18F]Av-45) For Positron Emission Tomography Amyloid Imaging
摘要:我们使用市售的自动化 Jfe 多功能合成仪开发了[18F]Florbetapir ([18F]Av-45) 的无乙醇制剂方法.我们还通过与传统的[18F]Av-45的10%乙醇溶液比较,评估了[18F]Av-45的无乙醇溶液在可见光照射和黑暗条件下的放射化学稳定性. [18F]Av-45的放射化学产率为55.1+/-2.2%(衰变校正至轰击结束),比活性为591.6+/-90.3Gbq/μmol,放射化学纯度>99%,总合成时间约为73 分钟发现通过溶解无乙醇溶液配制的[18 F]Av-45的放射化学纯度随着暴露于可见光的时间而降低.相反,通过在配方中添加 10% 乙醇或避免暴露在可见光下,可以抑制可见光光解作用.在通过溶解无乙醇溶液配制的[18 F]Av-45的放射合成中,通过避免暴露于可见光,可以获得高放射化学纯度和高稳定性的[18 F]Av-45.版权所有 © 2013 约翰.威利父子有限公司
DOI:10.1002/jlcr.3021

专利信息

专利号:US-10109385-B2
优先权日:2009-09-23
标题:Dose synthesis card for use with automated biomarker production system
发明人：MCFARLAND AARON; ANZELLOTTI ATILIO; HILLESHEIM DANIEL; BROWN-PROCTOR CLIVE; KHACHATURIAN MARK HAIG; LAND ANDREW
权利人:ABT MOLECULAR IMAGING INC
摘要:Microfluidic radiopharmaceutical production system and process for synthesizing per run approximately, but not less than, ten (10) unit doses of radiopharmaceutical biomarker for use in positron emission tomography (PET). A radioisotope from an accelerator or other radioisotope generator is introduced into a reaction vessel, along with organic and aqueous reagents, and the mixture heated to synthesize a solution of a pre-selected radiopharmaceutical. The solution is purified by passing through a combination of solid phase extraction purification components, trap and release components, and a filter. The synthesis process reduces waste and allows for production of biomarker radiopharmaceuticals on site and close to the location where the unit dose will be administered to the patient. On-site, as-needed production of radiopharmaceuticals in small doses reduces the time between synthesis of the radiopharmaceutical and administration of that radiopharmaceutical, minimizing loss of active isotopes through decay and allowing production of lesser amounts of radioisotopes overall.

专利号:US-12007376-B2
优先权日:2014-02-26
标题 :Method for determining a concentration of a synthesis component in a radiopharmaceutical sample
发明人：LEBEDEV ARTEM Y; ELIZAROV ARKADIJ M
权利人:TRACE ABILITY INC
摘要:A method for determining a concentration of a synthesis component in a radiopharmaceutical sample comprises providing an indicator, a metal or a metal complex, contacting the radiopharmaceutical sample with the indicator, metal or metal complex for a period of time sufficient to obtain an interaction, measuring an optical characteristic of the interacted components, and determining a concentration of the synthesis component in the radiopharmaceutical sample based on the measured optical characteristic.

专利号:US-2010172836-A1
优先权日:2008-12-31
标题 :Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof

专利号:BR-102015020840-B1
优先权日:2015-08-28
标题:BIPHENYL-DISULFIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND PROCESS FOR SYNTHESIS OF BENZOTHIAZOLIC DERIVATIVES

专利号:EP-2381967-B1
优先权日:2008-12-31
标题 :Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof
发明人：BENEDUM TYLER; GOLDING GEOFF; LIM NATHANIEL; ZHANG WEI
权利人:AVID RADIOPHARMACEUTICALS INC

专利号:EP-2381967-A1
优先权日:2008-12-31
标 题:Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof