CAS: 95603-44-4; (2α,3ξ,5β,7β,10β,13α)-4-Acetoxy-1,13-Dihydroxy-9-Oxo-7,10-Bis{[(2 ,2,2-Trichloroethoxy)Carbonyl]Oxy}-5,20-Epoxytax-11-En-2-Yl Benzo Ate

英文名称(2α,3ξ,5β,7β,10β,13α)-4-Acetoxy-1,13-Dihydroxy-9-Oxo-7,10-Bis{[(2 ,2,2-Trichloroethoxy)Carbonyl]Oxy}-5,20-Epoxytax-11-En-2-Yl Benzo Ate
中文名称7,10-二(2,2,2-三氯乙氧羰基)-10-脱乙酰基巴卡丁 III
CAS编号95603-44-4
MFCD编号:MFCD09840512
分子式:C35H38Cl6O14分子量:895.39
产品CID: 2009378
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: KYJMOHGTSXCPAI-CDTXAQBNSA-N
KYJMOHGTSXCPAI-CDTXAQBNSA-N
计算化学: 氢键受体数14.0氢键供体数2.0可旋转键数13.0

MSDS等安全信息

上下游产品

CAS号32981-86-5 10-脱乙酰基巴卡丁 III；... | CAS号17341-93-4 氯甲酸-2,2,2-三氯乙酯 | CAS号114915-14-9 多西紫杉醇中间体 | CAS号114915-16-1 N-Des-t-b°C-10-...

合成工艺路线路线简述

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Reagents: Pyridine Solvents: Dichloromethane; -10 °C; -10 °C -> Rt; 2.2 H,Rt
标题:Preparation Of 10-Deacetyl Paclitaxel
参考文献:China]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Solvents: Dichloromethane,Pyridine; 0 - 5 °C; 30 Min,0 - 10 °C1.2 Reagents: Water1.3 Reagents: Hydrochloric Acid Solvents: Water; Neutralized
标题:Preparation Of 10-Acetyldocetaxel
参考文献:China]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Solvents: Dichloromethane; 0 °C; 5 H,0 °C
标题:Method For Synthesis Of Paclitaxel And Docetaxel
参考文献:China]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Solvents: Dichloromethane,Pyridine; 10 Min,0 °C; 30 Min,0 °C; 0 °C -> Rt; 30 Min,Rt1.2 Reagents: Water
标题:Method For Synthesis Of Cabazitaxel From 10-Deacetylbaccatin Iii
参考文献:China]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Solvents: Dichloromethane,Pyridine; 45 - 60 Min,25 - 28 °C; 5 - 10 Min,25 - 30 °C1.2 Reagents: Water
标题:Alternative Synthesis And The Determination Of Absolute Configuration Of Docetaxel,An Anticancer Drug
作者:Sekhar,N. M.; Vishweshwar,Peddy; Acharyulu,Palle V. R.; Anjaneyulu,Yerramilli
参考文献:Synthetic Communications 日期:2012 卷标:42(23) 页码:3482-3492]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Reagents: Pyridine Solvents: Dichloromethane; 1 H,0 °C; 1 H,0 °C; > 0 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Cooled
标题:Method For Preparing Cabazitaxel From 10-Deacetylbaccatin Iii
参考文献:China]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Catalysts: Pyridine Solvents: Dichloromethane; 2 H,2 °C
标题:Preparation Of Cabazitaxel From 10-Deacetylbaccatin
参考文献:China]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Solvents: Chloroform,Pyridine; 100 S,10 Bar,50 °C1.2 Reagents: Hydrochloric Acid Solvents: Water
标题:Method For Preparing 7,10-Bis(Trichloromethoxy Formyl Chloride)-10-Deacetylate Baccatin Iii Using Microchannel Reactor
参考文献:China]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Reagents: Pyridine,Sodium Bicarbonate Solvents: Dichloromethane1.2 Rt; 3 H,Rt1.3 Reagents: Water; 0.5 H,Rt
标题:Industrial Process For Semisynthesis Of Docetaxel
参考文献:China]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; -5 - 0 °C; 1 H,-5 - 0 °C; 0 °C -> Rt; 4 H,Rt
标题:Synthesis Of Daxotere
作者:Li,Peng; Li,Chunxiang; Li,Xiang
参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2009 卷标:19(5) 页码:356-360]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; -5 - 0 °C; 1 H,-5 - 0 °C; 0 °C -> Rt; 4 H,Rt
标题:Synthesis Of Docetaxel
作者:Li,Peng; Li,Chunxiang
参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2009 卷标:40(2) 页码:90-92]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Solvents: Pyridine; 10 - 15 °C; 10 - 20 Min,10 - 15 °C; 10 Min,15 +/- 5 °C1.2 Reagents: Water
标题:Method For Preparation Of Docetaxel From 10-Deacetylbaccatin Iii
参考文献:China]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Reagents: Pyridine; 30 Min,Rt
标题:Design,Synthesis And Cytotoxicity Of Novel 3'-N-Alkoxycarbonyl Docetaxel Analogs
作者:Chang,Jun; Hao,Xiao-Dong; Hao,Yun-Peng; Lu,Hong-Fu; Yu,Jian-Ming; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2013 卷标:23(24) 页码:6834-6837]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Reagents: Pyridine Solvents: Dichloromethane; < 0 °C; 35 Min,0 °C1.2 Reagents: Water
标题:Regio- And Stereoselective Methods For The Conversion Of (2S,3R)-β-Phenylglycidic Acid Esters To Taxoids And Other Enantiopure (2R,3S)-Phenylisoserine Esters
作者:Afon'Kin,A. A.; Kostrikin,L. M.; Shumeiko,A. E.; Popov,A. F.; Matveev,A. A.; Et Al
参考文献:Russian Chemical Bulletin 日期:2012 卷标:61(11) 页码:2149-2162]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Solvents: Pyridine; Cooled; 0.5 H,0 °C -> Rt1.2 Reagents: Water; Rt
标题:Method For Synthesis Of Taxane Derivatives And Their Medicinal Application
参考文献:China]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Solvents: Pyridine; 1 H,15 - 17 °C; 30 Min,40 - 45 °C1.2 Reagents: Water; 10 Min; 30 Min
标题:Study On The Industrial Process For Docetaxel Synthesis
作者:Shi,Li-Bei; Zhang,Li-Chun; Niu,Hai-Bin; Feng,Jun-Jie
参考文献:Shanghai Yiyao 日期:2012 卷标:33(13) 页码:41-43]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Reagents: 4-(Dimethylamino)Pyridine Solvents: 1,4-Dioxane; 2 H,80 °C
标题:A Convenient And Easy-Controlled Method For Preparation Of 7,10-Bis(2,2,2-Trichloroethyloxycarbonyl)-10-Deacetyl Baccatin Iii
作者:Xin,Qi; Li,Xu; Xiao-Ju,Lin; Yong,Ji; Tian-Wei,Wang
参考文献:Chemical Research In Chinese Universities 日期:2004 卷标:20(6) 页码:813-816]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Solvents: Pyridine; 15 Min,Rt1.2 Solvents: Dichloromethane; 1 H,Rt; 5 Min,Rt1.3 Solvents: Water; 5 Min,Rt
标题:Processes For Preparing Docetaxel Crystalline Polymorphs
参考文献:World Intellectual Property Organization]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Solvents: Pyridine; Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Neutralized,Rt
标题:Process For Preparation Of Docetaxel Side Chain 2'-Derived Novel Taxanes Anti-Tumor Compound
参考文献:China]

32981-86-5 + 17341-93-4 = 95603-44-4
反应条件:1.1 Solvents: Pyridine; 63 - 95 °C
标题:Taxane Derivatives As Antineoplastic Compounds And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Cancer
参考文献:China

📜13-O-[(3R)-2-[n-Benzoyl(Carbamoyloxy)]-3-Bromo-3-Phenylpropionyl]-7,10-O,O'-Bis(2,2,2-Trichloroethoxycarbonyl)-10-Deacetylbaccatin置于sodium Hydride,Caesium Carbonate体系中,用四氢呋喃,Mineral Oil 作为反应溶剂,化学反应 3.5H,反应生成 7,10-二(2,2,2-三氯乙氧羰基)-10-脱乙酰基巴卡丁 Iii
参考文献:Regio-And Stereoselective Methods For The Conversion Of (2S,3R)-β-Phenylglycidic Acid Esters To Taxoids And Other Enantiopure (2R,3S)-Phenylisoserine Esters
标题:Regio-And Stereoselective Methods For The Conversion Of (2S,3R)-β-Phenylglycidic Acid Esters To Taxoids And Other Enantiopure (2R,3S)-Phenylisoserine Esters
摘要:提出了一种新的高效方法,用于合成含类固醇的对映体前体,即 (2R,3S)-和 (2S,3R)-N-苯甲酰基苯基异丝氨酸的甲酯以及类似的类固醇酯.该方法基于对相应的反式-β-苯基甘氨酸对映体进行区域和立体选择性氢溴酸分解,对得到的 3-溴烷烃进行 O-酰基氨基甲酰化的连续反应,分子内环化为 4-苯基恶唑啉-2-酮-5-羧酸衍生物,以及恶唑啉酮开环.
DOI:10.1007/s11172-012-0302-4