CAS: 86847-84-9; N-(6-Chloropyridin-2-yl)Pivalamide

该化合物是一种化学化合物,其特征为氨化功能组,并用氯原子取代了环.该化合物一般在室温中呈现固态,可溶于有机溶剂,反映其非极性特征,因为存在2-2-二甲基丙烯基甲基混合物.该成分有助于其潜在的生物活动,因为卤化经常存在于制药和农用化学中.氨化物的存在表明,该化合物可能参与氢联结,影响其溶性与再活性.此外,该化合物的结构可能具有特定的消毒性与电子特性,使其对医药化学和材料科学具有兴趣.应当参考安全数据,以便处理和储存,如同所有化学物质一样,确保采取适当的预防措施.

结构式图片

相似化合物

86847-59-8 1192814-44-0 1346447-30-0

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

6-chloropyridin-2-amine pivaloyl chlorideN-(6-chloro-3-formylpyridin-2-yl)-2,2-dimethylpropionamide 7-chloro-3-(2,6-dichlorophenyl)-1-methyl-1,8-naphthyridin-2(1H)-one 7-chloro-3-(2,6-dichlorophenyl)-1,8-naphthyridin-2(1H)-one 7-chloro-3-(2,6-dichlorophenyl)-1,8-naphthyridin-2-amine

合成工艺路线路线简述

  • 45644-21-1 = 86847-84-9
    反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; Cooled; Rt; 5 H,Rt
    标题:Synthesis Of 2-Amino-3-Bromo-6-Chloropyridine
    作者:Qin,Yu-Mei; Et Al
    参考文献:Huaxue Shiji 日期:2019 卷标:41(8) 页码:869-872]

    132784-74-8 = 86847-84-9
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water1.2 Reagents: Potassium Nitrite Solvents: Water
    标题:Substituted 1,8-Naphthyridin-2(1H)-Ones Are Superior To Thymine In The Recognition Of Adenine In Duplex As Well As Triplex Structures
    作者:Eldrup,Anne B.; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2002 卷标:124(13) 页码:3254-3262]

    141-86-6 = 86847-84-9
    反应条件:1.1 Solvents: 1,4-Dioxane2.1 Reagents: Hydrochloric Acid Solvents: Water2.2 Reagents: Potassium Nitrite Solvents: Water
    标题:Substituted 1,8-Naphthyridin-2(1H)-Ones Are Superior To Thymine In The Recognition Of Adenine In Duplex As Well As Triplex Structures
    作者:Eldrup,Anne B.; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2002 卷标:124(13) 页码:3254-3262]

    2402-78-0 = 86847-84-9
    反应条件:1.1 Reagents: Ammonia Solvents: Water; 12 H,180 °C2.1 Reagents: Sodium Bicarbonate Solvents: Dichloromethane; -5 - 25 °C; 5 H,20 °C
    标题:The Synthesis Of A Dopamine D2 Partial Agonist For The Treatment Of Schizophrenia
    作者:Magano,Javier; Et Al
    参考文献:Organic Process Research & Development 日期:2009 卷标:13(3) 页码:555-566
📜2,6-二氨基吡啶置于盐酸,Potassium Nitrite体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 7.0H,反应生成 N-(6-氯吡啶-2-基)-2,2-二甲基丙酰胺
参考文献:Substituted 1,8-Naphthyridin-2(1H)-Ones Are Superior To Thymine In The Recognition Of Adenine In Duplex As Well As Triplex Structures
标题:Substituted 1,8-Naphthyridin-2(1H)-Ones Are Superior To Thymine In The Recognition Of Adenine In Duplex As Well As Triplex Structures
摘要:The Synthesis And Evaluation Of A Series Of Novel Nucleobases Based On Substituted 1,8-Naphthyridin-2(1H)-Ones Are Reported. The Nucleobases Were Designed To Meet The Requirements For Incorporation Into Peptide Nucleic Acids (Pnas) And Were Evaluated As Part Of Pna Duplex And Triplex Nucleic Acid Recognition Systems. Of The Various Nucleobases Tested,Only The 7-Chloro-1,8-Naphthyridin-2(1H)-One (7-Cl-Bt) Nucleobase Led To Consistently Increased Affinity In All Recognition Systems,Duplex (Watson-Crick) As Well As Triplex (Hoogsteen). For Multiply Modified Systems,The Increase In Thermal Stability Per Modification Was Dependent On The Sequence Context,Ranging From 2.0 Degreesc (In Separate Positions) To 3.5 Degreesc (In Adjacent Positions) In Pna-Dna Duplexes And From 1.2 Degreesc (In Separate Positions) To 3.2 Degreesc (In Adjacent Positions) In Pna-Rna Duplexes. Singly Mismatched Oligonucleotide Targets Were Employed To Demonstrate Uncompromised Sequence Discrimination. When Part Of Multiply Modified Triplex (Hoogsteen) Recognition Systems,The 7-Cl-Bt Unit Gave Rise To Increases In The Thermal Stability Ranging From 2.7 To 3.5 Degreesc When Incorporated Into Separated And Adjacent Positions,Respectively. Our Results Furthermore Indicate That The Duplex Stabilization Is Predominantly Enthalpic And Therefore Most Likely Not A Consequence Of Single-Strand Preorganization. Finally,And Most Surprisingly,We Find No Direct Correlation Between The Endstacking Efficiency Of This Type Of Nucleobase And Its Helix Stabilization When Involved In Watson-Crick Base Pairing Within A Helix.
DOI:10.1021/ja0117027

海关参考信息

专利信息


专利号:WO-2011050245-A1
优先权日:2009-10-23
标 题:Bicyclic heteroaryls as kinase inhibitors
发明人：FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
权利人:FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
摘要:The invention is directed to heteroaryl compounds useful as inhibitors of various kinase enzymes. In various embodiments, the invention provides a heteroaryl compound having inhibitory bioactivity with respect to a Rho kinase, an AKT kinase, a p70S6K kinase, a LIM kinase, an IKK kinase, a Flt kinase, an Aurora kinase, or a Src kinase, or any combination thereof. Compounds of the invention include bicyclic heteroaryl compounds of formula (I), which can contain a bridging nitrogen atom at a ring junction. The invention further provides methods of synthesis of compounds of the invention, pharmaceutical compositions, pharmaceutical combinations, and methods of treatment of malconditions using compounds of the invention.

专利号:CN-102875455-A
优先权日:2012-10-23
标题:A kind of synthesis technique of 3,6-dichloro-2-aminopyridine

专利号:CN-102875456-B
优先权日:2012-10-23
标 题:The chemical synthesis method of 3,6-dichloro-2-aminopyridine

专利号:CN-102875456-A
优先权日:2012-10-23
标 题 :The chemical synthesis method of 3,6-dichloro-2-aminopyridine

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.1055/s-0033-1339529
摘要:Synthesis of a Mineralocorticoid Antagonist. Synfacts. 2013 Aug 19;9(09):0924. doi: 10.1055/s-0033-1339529.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知