CAS: 83159-91-5; (4S,5R)-4-((Tert-Butyldimethylsilyl)Oxy)-5-(((Tert-Butyldimethylsilyl)Oxy)Methyl)Dihydrofuran-2(3H)-One
该化合物是属于硅酸类的化学化合物,通常用于有机合成和氢氧功能的保护组,并用作该类的有机合成和保护组.该化合物具有乳腺内酯结构特征,表明存在源自氢氧化酸凝聚的循环酯,表明存在一种循环酯酯酯,该化合物来自氢氧化酸的凝聚物.这种改变在生物化学应用中意义重大,特别是在核核糖类比合和用于医药化学的其他衍生物中.该化合物在合成过程中的特性通常是其有机溶解剂的中间性,在合成化学条件下的溶解性.
- 英文名称(4S,5R)-4-((Tert-Butyldimethylsilyl)Oxy)-5-(((Tert-Butyldimethylsilyl)Oxy)Methyl)Dihydrofuran-2(3H)-One
- 中文名称(4S,5R)-4-[(叔丁基二甲硅烷基)氧基]-5-{[(叔丁基二甲基硅烷基)氧基]甲基}氧杂环戊烷-2-酮
- IUPAC名称(4S,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)dihydrofuran-2(3H)-one
- 其它别名3,5-二-O-(T-丁基二甲基硅烷)-2-脱氧-D-Ribono-1,4-Lactone; 3,5-Di-O-(Tert-Butyldimethylsilyl)-2-Deoxy-D-Ribonolactone
- CAS编号83159-91-5
- MFCD编号:MFCD01630917
- 分子式:C17H36O4Si2分子量:360.64
- 产品CID: 1820602
- 产品分类有机原料→通用试剂→保护和衍生化试剂
相似化合物
34371-14-7 38996-14-4 1173700-22-5物理性质
上下游产品
CAS号18162-48-6 叔丁基二甲基氯硅烷 | CAS号34371-14-7 (4S,5R)-4-羟基-5-... | CAS号83159-90-4 (-)-(S)-3-((R)-... | CAS号452-51-7 2-deoxy-D-ribof... | CAS号83159-89-1 ethyl (S)-5-((R... | CAS号167023-13-4 2',5'-di-O-(ter... | CAS号210640-60-1 1-((2S,4S,5R)-4... | CAS号173327-56-5 1,4-ANHYDRO-2-D...合成工艺路线路线简述
- 18162-48-6 + 533-67-5 = 83159-91-5
反应条件:1.1 Reagents: Bromine Solvents: Water; Rt1.2 Reagents: Silver Carbonate; Neutralized,Rt1.3 Reagents: Imidazole Solvents: Dimethylformamide; 16 H,Rt
标题:Synthesis Of Functionalized Biphenyl-C-Nucleosides And Their Incorporation Into Oligodeoxynucleotides
作者:Zahn,Alain; Et Al
参考文献:Bioorganic & Medicinal Chemistry 日期:2006 卷标:14(18) 页码:6174-6188]
= 83159-91-5 + 1173700-29-2
反应条件:1.1 Reagents: Silylene,(Fluoroimino)- Solvents: Tetrahydrofuran; Rt -> -78 °C1.2 Reagents: Lithium Bis(Trimethylsilyl)Amide Solvents: Tetrahydrofuran; 1 H,-78 °C1.3 Reagents: Ammonium Chloride Solvents: Water; -78 °C -> Rt
标题:Diastereo-Controlled Electrophilic Fluorinations Of 2-Deoxyribonolactone: Syntheses Of All Corresponding 2-Deoxy-2-Fluoro-Lactones And 2'-Deoxy-2'-Fluoro-Nad+s
作者:Cen,Yana; Et Al
参考文献:Journal Of Organic Chemistry 日期:2009 卷标:74(16) 页码:5779-5789]
27607-77-8 + 83159-91-5 = 83159-91-5 + 1173700-29-2
反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 2 H,0 °C1.2 Reagents: Ammonium Chloride Solvents: Water; 0 °C -> Rt2.1 Reagents: Silylene,(Fluoroimino)- Solvents: Tetrahydrofuran; Rt -> -78 °C2.2 Reagents: Lithium Bis(Trimethylsilyl)Amide Solvents: Tetrahydrofuran; 1 H,-78 °C2.3 Reagents: Ammonium Chloride Solvents: Water; -78 °C -> Rt
标题:Diastereo-Controlled Electrophilic Fluorinations Of 2-Deoxyribonolactone: Syntheses Of All Corresponding 2-Deoxy-2-Fluoro-Lactones And 2'-Deoxy-2'-Fluoro-Nad+s
作者:Cen,Yana; Et Al
参考文献:Journal Of Organic Chemistry 日期:2009 卷标:74(16) 页码:5779-5789]
18162-48-6 + 533-67-5 = 83159-91-5 + 1173700-29-2
反应条件:1.1 Reagents: Bromine Solvents: Water; 5 D,Rt1.2 Reagents: Silver Carbonate; Ph 7,Rt1.3 Reagents: Imidazole Solvents: Dimethylformamide; 24 H,Rt1.4 Solvents: Water; Rt2.1 Reagents: Triethylamine Solvents: Dichloromethane; 2 H,0 °C2.2 Reagents: Ammonium Chloride Solvents: Water; 0 °C -> Rt3.1 Reagents: Silylene,(Fluoroimino)- Solvents: Tetrahydrofuran; Rt -> -78 °C3.2 Reagents: Lithium Bis(Trimethylsilyl)Amide Solvents: Tetrahydrofuran; 1 H,-78 °C3.3 Reagents: Ammonium Chloride Solvents: Water; -78 °C -> Rt
标题:Diastereo-Controlled Electrophilic Fluorinations Of 2-Deoxyribonolactone: Syntheses Of All Corresponding 2-Deoxy-2-Fluoro-Lactones And 2'-Deoxy-2'-Fluoro-Nad+s
作者:Cen,Yana; Et Al
参考文献:Journal Of Organic Chemistry 日期:2009 卷标:74(16) 页码:5779-5789]
18162-48-6 + 34371-14-7 + 78185-08-7 = 83159-91-5 + 106183-57-7 + 106183-56-6 + 106183-58-8
反应条件:1.1 Reagents: Pyridine Solvents: Dichloromethane
标题:Efficient Synthesis Of (S)-5-(Hydroxymethyl)-5(H)-Furan-2-One From D-Mannitol
作者:Danilova,G. A.; Et Al
参考文献:Tetrahedron Letters 日期:1986 卷标:27(22) 页码:2489-90]
106183-54-4 = 83159-91-5 + 106183-57-7 + 106183-56-6 + 106183-58-8
反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Water2.1 Reagents: Pyridine Solvents: Dichloromethane
标题:Efficient Synthesis Of (S)-5-(Hydroxymethyl)-5(H)-Furan-2-One From D-Mannitol
作者:Danilova,G. A.; Et Al
参考文献:Tetrahedron Letters 日期:1986 卷标:27(22) 页码:2489-90]
18162-48-6 + 34371-14-7 = 83159-91-5
反应条件:1.1 Reagents: Imidazole Solvents: Dimethylformamide; 12 H,Rt
标题:Direct And Facile Syntheses Of Heterocyclic Vinyl-C-Nucleosides For Recognition Of Inverted Base Pairs By Dna Triple Helix Formation: First Report By Direct Wittig Route
作者:Rothman,Jeffrey H.
参考文献:Journal Of Organic Chemistry 日期:2007 卷标:72(10) 页码:3945-3948]
18162-48-6 + 34371-14-7 = 83159-91-5
反应条件:1.1 Reagents: Imidazole Solvents: Dimethylformamide; 1 D,Rt1.2 Reagents: Water; Rt
标题:Synthesis Of Isomeric Analogues Of S-Ribosylhomocysteine Analogues With Homocysteine Unit Attached To C2 Of Ribose
作者:Chbib,Christiane
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2017 卷标:27(8) 页码:1681-1685]
18162-48-6 + 533-67-5 = 83159-91-5
反应条件:1.1 Reagents: Bromine Solvents: Water; 5 D,Rt1.2 Reagents: Silver Carbonate; Ph 7,Rt1.3 Reagents: Imidazole Solvents: Dimethylformamide; 24 H,Rt1.4 Solvents: Water; Rt
标题:Diastereo-Controlled Electrophilic Fluorinations Of 2-Deoxyribonolactone: Syntheses Of All Corresponding 2-Deoxy-2-Fluoro-Lactones And 2'-Deoxy-2'-Fluoro-Nad+s
作者:Cen,Yana; Et Al
参考文献:Journal Of Organic Chemistry 日期:2009 卷标:74(16) 页码:5779-5789]
1724-14-7 = 83159-91-5
反应条件:1.1 Reagents: Bromine Solvents: Water; 5 D,Rt1.2 Reagents: Silver Carbonate; Ph 7,Rt2.1 Reagents: Imidazole Solvents: Dimethylformamide; 1 D,Rt2.2 Reagents: Water; Rt
标题:Synthesis Of Isomeric Analogues Of S-Ribosylhomocysteine Analogues With Homocysteine Unit Attached To C2 Of Ribose
作者:Chbib,Christiane
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2017 卷标:27(8) 页码:1681-1685]
15186-48-8 + 53503-61-0 = 83159-91-5 + 106183-57-7 + 106183-56-6 + 106183-58-8
反应条件:1.1 Solvents: Tetrahydrofuran,Hexane2.1 Reagents: Trifluoroacetic Acid Solvents: Water3.1 Reagents: Pyridine Solvents: Dichloromethane
标题:Efficient Synthesis Of (S)-5-(Hydroxymethyl)-5(H)-Furan-2-One From D-Mannitol
作者:Danilova,G. A.; Et Al
参考文献:Tetrahedron Letters 日期:1986 卷标:27(22) 页码:2489-90
📜2-Deoxy-D-Ribose置于咪唑,溴体系中,化学反应生成 3,5-二-O-(叔丁基二甲基硅烷)-2-脱氧-D-核糖酸-1,4-内酯
参考文献:改进的1,2-二脱氧-β-1-苯基-D-呋喃呋喃糖途径.
标题:改进的1,2-二脱氧-β-1-苯基-D-呋喃呋喃糖途径.
摘要:描述了一种有效合成芳基核苷类似物1,2-二脱氧-β-1-苯基-D-呋喃呋喃糖(1)的方法.该路线利用向保护的2-脱氧核糖内酯中加入苯基锂,然后用三乙基硅烷/三氟化硼醚化物还原以选择性地产生β-异头物.脱保护从2-脱氧-D-核糖产生所需芳基c-核苷的总产率为27%.
DOI:10.1016/s0960-894X(98)00632-5
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合成参考文献
参考DOI号:10.1021/jo00004a040
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