CAS: 6850-57-3; (2-Methoxyphenyl)Methanamine

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CAS号135-02-4 邻甲氧基苯甲醛 | CAS号6609-56-9 2-甲氧基氰苯 | CAS号29577-53-5 2-甲氧基苯甲醛肟 | CAS号17608-09-2 2-甲氧基异硫氰酸苄酯 | CAS号67-56-1 甲醇 | CAS号63452-53-9 ACETAMIDE, N-[(... | CAS号300823-47-6 1-(azidomethyl)... | CAS号860567-26-6 α'-amino-2,2'-d... | CAS号2439-77-2 2-甲氧基苯甲酰胺 | CAS号55-21-0 苯甲酰胺 | CAS号623-03-0 对氯苯腈 | CAS号579-75-9 邻甲氧基苯甲酸 | CAS号6609-56-9 2-甲氧基氰苯 | CAS号93489-08-8 2-甲氧苄基异氰酸酯 | CAS号932-30-9 2-羟基苄胺 | CAS号135-02-4 邻甲氧基苯甲醛 | CAS号69875-89-4 苄基-(2-甲氧基苄基)胺 | CAS号2439-77-2 2-甲氧基苯甲酰胺 | CAS号6851-80-5 N-甲基-2-甲氧基苄胺

邻甲氧基苯甲醛置于氨,氢气体系中,用 甲醇 作为反应溶剂,90.0 °C,2.0 Mpa 条件下,反应 4.0H,以99%的收率获得产物邻甲氧基苄胺
参考文献:可控石墨烯共壳可重复使用ni / Nio纳米粒子的简便合成及其在温和条件下胺合成中的应用
标题:可控石墨烯共壳可重复使用ni / Nio纳米粒子的简便合成及其在温和条件下胺合成中的应用
摘要:化学合成中许多研究人员的主要目标是开发可回收和易于使用的催化剂.这些催化剂应优选由富含地球的金属制成,并具有用于合成药学上重要的化合物的能力.胺被列为特权化合物,并广泛用于精细和大宗化学工业以及制药和材料研究.在许多实验室和工业中,主要使用氨和h 2进行过渡金属催化的羰基化合物的还原胺化反应.但是,这些反应通常需要贵金属基催化剂或raney®镍,并且要求苛刻的反应条件,并且对所需产物的选择性较低.本文中,我们描述了一种简单且环保的方法,用于制备薄石墨烯球,该球体封装了使用柠檬酸镍作为前体的均匀ni / Nio纳米合金催化剂(ni / Nio @ C).所得催化剂稳定且可重复使用,并且已成功用于伯,仲,叔和n-甲胺的合成(超过62个实例).该反应在非常温和的工业可行且可扩展的条件下(80oc和1 Mpa H 2)将易于获得的羰基化合物(醛和酮)与氨,胺和h 2偶联压力(4小时)后,可以经济高
DOI:10.1039/d0Gc02421J

专利信息

专利号:WO-0140193-A1
优先权日:1999-12-03
标题:Method for the synthesis of pyrazolines
发明人：BOLDI ARMEN M
权利人:CHEMRX ADVANCED TECHNOLOGIES I; BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula (I). Also claimed are novel intermediates and their methods of synthesis.

专利号:US-2002103381-A1
优先权日:2000-11-30
标 题 :Method for the synthesis of pyrazolines
发明人：BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula I: n n n Also claimed are novel intermediates and their methods of synthesis.

专利号:US-6175020-B1
优先权日:1999-04-09
标题 :Spirodiamino acid scaffold for combinatorial synthesis
发明人：DOLLE III ROLAND ELLWOOD; BARDEN MICHAEL C
权利人:PHARMACOPEIA INC
摘要:Azaspirononanes of formula I and their synthesis n are disclosed. The compounds are useful as templates for constructing synthetic receptors and as intermediates in the synthesis of enzyme inhibitors. They are prepared by an intramolecular ylide cycloaddition of a 6-hydrazone of 2,10-undecadienoic acid ester.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-9018371-B2
优先权日:2007-03-07
标 题 :Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient
发明人：JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH
权利人:JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH; FM THERAPEUTICS CO LTD; US OF AMERICA AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES THE OFFICE OF TECHNO
摘要:Disclosed are adenosine derivatives, methods for the synthesis thereof, and pharmaceutical compositions for the prevention and treatment of inflammatory diseases, comprising the same as an active ingredient. The adenosine derivatives have high binding affinity and selectivity for adenosine receptors, especially for A 3 adenosine receptors and act as A 3 adenosine receptor antagonists, and exhibit anti-inflammatory activity. Thus, the adenosine derivatives are useful in the prevention and treatment of inflammatory diseases.

专利号:US-2025049791-A1
优先权日:2023-08-03
标题:Synthesis of MEK7 Inhibitors and methods of Use Thereof
发明人：SCHEIDT KARL A; KIM DALTON ROBERT; ORR MEGHAN JO
权利人:UNIV NORTHWESTERN
摘要:Disclosed herein are 4-phenoxypyrimidine compounds and derivatives thereof for use as inhibitors of mitogen-activated protein kinase 7 (MEK7). The disclosed compounds and pharmaceutical compositions thereof may be used in methods for treating a disease or disorder associated with MEK7 activity, including cell proliferative diseases and disorders associated with MEK7 activity, such as cancer.