CAS: 66258-76-2; Piperacillin
该化合物是一种半合成二硝基苯丙胺抗生素,主要用于治疗各种细菌感染,其特征是,它具有广泛频谱性,对抗模性细菌和克丁阴性细菌都具有抗药性,因此能够有效治疗Pseudomonas aeruginosa等有机体引起的感染.从物理特性来看,管状氨的化学结构包括一个乙酯环,该环是其抗菌活动必不可少的,以及一个侧链,它能增强该环的稳定性,防止某些乙酯和某些细菌产生的酶产生抗药性.Piperacillin 单体水合物通常通过注射来施用,并且往往与乙型乳酶抑制剂(例如 tazobactamm)结合,以进一步扩大其抗抗药性.从物理特性看,它是一种白色到白色的晶状粉粉,在水中可以溶解.单水形式表明存在一种与每种烟素分子相关的水分子的分子,可以影响其稳定性和抗性.
- 英文名称Piperacillin
- 中文名称氯噻酮
- 其它别名(2s,5r,6r)-6-[[(2r)-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- CAS编号66258-76-2
- MFCD编号:MFCD26142884
- EINECS号:811-368-4
- FDA UNII编号:X00B0D5O0E
- 分子式:C23H29N5O8S分子量:535.57
- 产品CID: 1643676
- 产品分类原料药 → 泌尿系统用药 → 利尿药
物理性质
MSDS等安全信息
欧盟法规
C&L通报合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905130000-正丁醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9604985-B2
优先权日:2013-06-10
标 题 :Process for the preparation of chiral tert-butyl 4-((1R,2S,5R)-6(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carb derivatives and (2S,5R)-7-oxo-N-piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
发明人：MILLER STEVEN P; LIMANTO JOHN; ZHONG YONG-LI; YASUDA NOBUYOSHI; LIU ZHIJIAN
权利人:MERCK SHARP & DOHME
摘要:A process for the preparation of N-protected 6-(piperidin-4-ylcarbamoyl)piperidin-3-yl sulfonates of Formula (III): which comprises contacting a lactone of Formula (II): with an azacycloalkylamine of formula (II-Am): followed by contact with a sulfonyl halide of formula (II-Su): R 4 —SO 2 W (II-Su) in the presence of tertiary amine base, wherein P G1 and P G2 are amine protective groups; k, p and q are 0, 1, or 2, and W, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are defined herein. Additional embodiments add a series of process steps leading to the synthesis of 7-oxo-1,6-diazabicyclo[3.2.1]octanes suitable for use as β-lactamase inhibitors.
