CAS: 659-40-5; 4,4'-(Hexane-1,6-Diylbis(Oxy))Dibenzimidamide Bis(2-Hydroxyethanesulfonate)

1,6-二溴己烷置于tungstate Sulfuric Acid,Ammonium Acetate,Potassium Carbonate,碳酸二甲酯体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 63.25H,反应生成 羟乙磺酸己氧苯脒
参考文献:一种己脒定及己脒定二羟乙基磺酸盐的催化合成方法
标题:一种己脒定及己脒定二羟乙基磺酸盐的催化合成方法
摘要:本发明公开了一种己脒定及己脒定二羟乙基磺酸盐的催化合成方法,己脒定的催化合成方法,包括以下步骤:步骤101)将4‑羟基苯甲腈,1,6‑二溴己烷,碱和第一溶剂,经回流反应得到1,6‑(对氰基苯基)己二醚;步骤102)将催化剂添加到第二溶剂中,并加入铵盐,搅拌均匀后,再加入1,6‑(对氰基苯基)己二醚,反应后得到反应混合液;将反应混合液冷却至室温后过滤,得到沉淀物和滤液;将滤液浓缩和重结晶后得到己脒定.本发明的己脒定及己脒定二羟乙基磺酸盐的催化合成方法,反应条件温和,操作简单,步骤少,试剂绿色和产物纯度高.

专利信息

专利号:US-8858968-B2
优先权日:2005-12-05
标题 :Use of tyrosine-arginine dipeptide and niacinamide as substance P antagonist
发明人：POTIN ANTHONY
权利人:POTIN ANTHONY; OREAL
摘要:Use of the combination of the tyrosine-arginine dipeptide or derivatives thereof and of niacinamide as a substance P antagonist for treating red blotches on the skin, skin oedema and sensitive skin. Use of this combination for the preparation of a composition for use in treating disorders associated with an excess synthesis and/or release of substance P.

专利号:US-2013164265-A1
优先权日:2011-12-21
标题 :Skin care compositions
发明人：FLAVIN DANA; OBENLAND SIGRID
权利人:FLAVIN DANA; OBENLAND SIGRID
摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.

专利号:US-2014328952-A1
优先权日:2011-12-21
标题:Topical compositions
发明人：FLAVIN DANA
权利人:FLAVIN DANA
摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.