CAS: 581772-29-4; 2-((4R,6R)-6-(2-(2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Phenylcarbamoyl)-1H-Pyrrol-1-yl)Ethyl)-2,2-Dimethyl-1,3-Dioxan-4-yl)Acetic Acid

该化合物是多环结构和各种功能组.它具有一个以其芳香特性而闻名的发烧环,并含有二氧杂交,有助于其潜在的溶性和再活性.一个含氟联的组的存在表明生物活动或亲脂性有所增强,而苯基碳基组可能表明生物系统中的潜在相互作用.由(4R,6R)配置所显示的立体化学学表明,具体空间安排能够影响化合物的生物活动和药理学.

结构式图片

物理性质

MSDS等安全信息

    上下游产品

    lipitor 2,2-dimethoxy-propane tert-butyl (4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate methyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetateatorvastatin lactone (Z)-4-hydroxybut-2-enyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (3R,5R)-((Z)-4-((1-(nitrooxy)ethoxy)carbonyloxy)but-2-enyl) 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate (3R,5R)-((Z)-4-((1-chloroethoxy)carbonyloxy)but-2-enyl) 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate

    合成工艺路线路线简述

      📜Lipitor置于硫酸,水,对甲苯磺酸,Sodium Hydroxide体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 22.0H,反应生成 阿托伐他汀缩丙酮
      参考文献:阿托伐他汀酯类药物的合成和评价,该药为人羧酸酯酶代谢激活的药物
      标题:阿托伐他汀酯类药物的合成和评价,该药为人羧酸酯酶代谢激活的药物
      摘要:我们以中等至高收率合成了11种具有阿托伐他汀酯化羧酸部分的前药.我们发现,它们通过人类羧酸酯酶1(ces1)同工酶特别地经历了代谢激活.结果表明,阿托伐他汀的这些酯化合物具有在体内充当前药的潜力.
      DOI:10.1016/j.Bmcl.2015.12.069

      海关参考信息

      专利信息


      专利号:WO-2007096751-A1
      优先权日:2006-02-21
      标题 :Process for the preparation of atorvastatin calcium
      发明人：PATEL DHIMANT JASUBHAI; KUMAR RAJIV; DWIVEDI SHRI PRAKASH DHAR
      权利人:CADILA HEALTHCARE LTD; PATEL DHIMANT JASUBHAI; KUMAR RAJIV; DWIVEDI SHRI PRAKASH DHAR
      摘要:The present invention relates to process for the preparation of atorvastatin calcium. The process provides the novel approach for the synthesis of an important intermediate atorvastatin protected diol chemically (4R-cis)-6-[-2-[3-phenyl-4-(phenyl- carbamoyl)-2-(4-flourophenyl)-5-(1-methyl-ethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl- [1,3]dioxane-4-yl-acetic acid-tertriay butyl ester for atorvastatin calcium i.e. [R- (R*,R*)]-2-(4-fluorophenyl-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4- [(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1). The present invention relates the use of amino side chain i.e [6-(2-aminoethyl)-2,2,-dimethyl- [1,3]dioxan-4-yl]-acetic acid tert-butyl ester and stetter compound i.e. 4-(4- FluoroÏ?henyl)-2-isobutryl-4-oxo-N-phenyl butryl amide as an important starting materials for the preparation of atorvastatin protected diol in the high yield and thereby the recovery of amino side chain with an industrially applicable process.

      专利号:EP-1490333-B1
      优先权日:2002-03-28
      标题 :New atorvastatin salts and pharmaceutical compositions containing them
      发明人：FISCHER JANOS; VUKICS KRISZTINA; ERDELYI PETER; HEGEDUES BELA; TIHANYI KAROLY; VASTAG MONIKA; LEVAI SANDOR; BALINT SANDORNE; LANCZOS KRISZTINA
      权利人:RICHTER GEDEON NYRT
      摘要:The invention relates to salts of atorvastatin formed with a basic amino acid of the general formula (I), where the meaning of R is a group originated from lysine, arginine or ornithine, and the amorphous or polymorph modifications thereof. The invention also relates to the synthesis of the compounds of the general formula (I).

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      合成参考文献


      参考文献:10.1055/s-0030-1259402
      摘要:Synthesis of Atorvastatin Lactone. Synfacts. 2011 Feb 16;2011(03):0242. doi: 10.1055/s-0030-1259402.
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