CAS: 57948-41-1; 3-Bromoimidazo[1,2-A]Pyrazine

相似化合物

87597-26-0 957344-74-0 63744-24-1

上下游产品

imidazo[1,2-a]pyrazine 3-phenylimidazo[1,2-a]pyrazine 4-trifluoromethyl-N-imidazo[1,2-a]pyrazin-3-ylbenzamide

吲哚[1,2-A]吡嗪置于溴,Sodium Acetate,Potassium Bromide体系中,用 甲醇 作为反应溶剂,化学反应 0.17H,反应生成 3-溴咪唑[1,2-A]吡嗪
参考文献: 5,6,7,8-Tetrahydroimidazo[1,2-A]Pyrazine Derivatives As P2X7 Modulators[fr] Dérivés De 5,6,7,8-Tétrahydroimidazo[1,2-A]Pyrazine Comme Modulateurs De P2X7
标题: 5,6,7,8-Tetrahydroimidazo[1,2-A]Pyrazine Derivatives As P2X7 Modulators[fr] Dérivés De 5,6,7,8-Tétrahydroimidazo[1,2-A]Pyrazine Comme Modulateurs De P2X7
摘要:本发明提供了一种具有以下式(i)的化合物或其药学上可接受的盐:其中a为氢,C1-4烷基,C3-6环烷基,C1-3烷氧基,C1-3烷氧基c1-4烷基,C1-2氟代烷基,卤素,Nr6R7可选择地取代的杂芳基(het)或可选择地取代的苯基,R1,R2,R3,R4,R5,R6和r7如描述中所定义.认为这些化合物或盐能够调节p2X7受体功能,并能够拮抗p2X7受体上atp的作用.本发明还提供了该化合物或盐在治疗或预防炎症性疼痛,神经病性疼痛,内脏疼痛,类风湿性关节炎或骨关节炎或神经退行性疾病等疾病中的用途.

专利信息

专利号:US-8378104-B2
优先权日:2010-02-11
标 题 :7-aminofuropyridine derivatives
发明人：HORNBERGER KEITH R; BERGER DAN M; CHEN XIN; CREW ANDREW P; DONG HANQING; KLEINBERG ANDREW; LI AN-HU; MA LIFU; MULVIHILL MARK J; PANICKER BIJOY; SIU KAM W; STEINIG ARNO G; TARRANT JAMES G; WANG JING; WENG QINGHUA; SANGEM RAJARAM; GUPTA RAMESH C
权利人:OSI PHARMACEUTICALS LLC; HORNBERGER KEITH R; BERGER DAN M; CHEN XIN; CREW ANDREW P; DONG HANQING; KLEINBERG ANDREW; LI AN-HU; MA LIFU; MULVIHILL MARK J; PANICKER BIJOY; SIU KAM W; STEINIG ARNO G; TARRANT JAMES G; WANG JING; WENG QINGHUA; SANGEM RAJARAM; GUPTA RAMESH C
摘要:Compounds of Formula 1, as shown below and defined herein: n n n n n n n n n n n n pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by TAK1 or for which an appropriate TAK1 inhibitor is effective. This Abstract is not limiting of the invention.