CAS: 51077-14-6; (S)-1-(Tert-Butoxycarbonyl)Azetidine-2-Carboxylic Acid

相似化合物

228857-58-7 159749-28-7 136552-06-2

上下游产品

(S)-1-Boc-2-氮杂环丁烷甲醇 2-(S)-Hydroxymethyl-Azetidine-1-Carboxylic Acid Tert-Butyl Ester 161511-85-9

(S)-1-Boc-2-氮杂环丁烷甲醇置于sodium Hypochlorite,碳酸氢钠,硫酸,氟氯氰菊酯,Sodium Thiosulfate,Sodium Bromide体系中,用 水,乙酸乙酯 作为反应溶剂,化学反应生成 1-Boc-L-吖啶-2-羧酸
参考文献:Processes For Producing Azetidine-2-Carboxylic Acid And Intermediates
标题:Processes For Producing Azetidine-2-Carboxylic Acid And Intermediates
摘要:本发明的目的是提供一种生产氮杂环丙氨酸及其中间体的方法,该方法高效,经济且适合工业实践.本发明涉及一种生产氮杂环丙氨酸的方法,包括将一般式(1)所代表的4-氧代-2-氮杂环丙氨酸衍生物经氢化还原得到以下式(2)所示的氮杂环丙醇,将其与氨基保护剂处理得到以下一般式(3)所示的n-保护的氮杂环丙醇,将其与氧化剂处理得到以下一般式(4)所示的n-保护的氮杂环丙氨酸,并进一步对其氨基保护基进行消除.

专利信息

专利号:US-8329686-B2
优先权日:2006-08-29
标题:Isatin analogues and uses therefor
发明人：MACH ROBERT H; WELCH MICHAEL; CHU WENHUA; ROTHFUSS JUSTIN
权利人:MACH ROBERT H; WELCH MICHAEL; CHU WENHUA; ROTHFUSS JUSTIN; UNIV WASHINGTON
摘要:Novel isatin analogues, including isatin analogues comprising Michael Acceptors (IMAs) are disclosed. Further disclosed are methods of synthesis of the isatin analogues, and uses of the analogues, including inhibition of caspase-3 and caspase-7, and in vivo imaging of apoptosis by Positron emission tomography (PET) or Single Photon Emission Computed Tomography (SPECT).

专利号:RU-2026296-C1
优先权日:1988-06-20
标题 :Method of synthesis of nitrogen-containing heterocyclic compounds or their pharmaceutically acceptable salts

专利号:RU-2176645-C2
优先权日:1995-07-06
标 题:Thrombin inhibitors, pharmaceutical composition based on thereof, method of treatment, method of their synthesis (versions) and protected derivative