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CAS号2207-50-3 氨苯恶唑啉 | CAS号407-25-0 三氟乙酸酐(TFAH) | CAS号556-64-9 硫氰酸甲酯 | CAS号76-05-1 三氟乙酸(TFA) | CAS号353-85-5 三氟乙腈 | CAS号14565-32-3 三氟乙酰基异氰酸酯 | CAS号616-05-7 2-溴己酸 | CAS号354-38-1 三氟乙酰胺 | CAS号60956-76-5 3,3,3-trifluoro... | CAS号2925-25-9 2,2,2-trifluoro... | CAS号354-38-1 三氟乙酰胺 | CAS号331-04-4 2,2,2-trifluoro... | CAS号2561-21-9 Trifluoroacetic...

📜三氟乙腈,三氟乙酸 反应生成 双三氟乙酰胺
参考文献:Fluorocarbon Nitrogen Compounds. Vii.1 The Indirect Fluorination Of Some Fluorocarbon Nitrogen Derivatives2
标题:Fluorocarbon Nitrogen Compounds. Vii.1 The Indirect Fluorination Of Some Fluorocarbon Nitrogen Derivatives2
摘要:The Indirect Fluorination Of Some Fluorocarbon Nitrogen Compounds Has Been Investigated And Reactions Of The Following Functional Groups Have Been Determined Under Mild Conditions:-N=c<,N C-,C-(-N = C<)(8),>N-H,>Ncof,-N = C = O,-Nhcof,-Conh2 And-Conhco-. Fluorocarbon N-F Compounds Can Be Synthesized In Certain Cases By The Action Of Silver Difluoride On Carbon-Nitrogen Unsaturation,By Replacement Of Amine Hydrogen Or By Cleavage Of An Acyl Group From Nitrogen. Rearrangement And Coupling Of The Free Radical Intermediates Are Competitive With N-F Bond Formation,Coupling Becoming More Important With Progressively Milder Conditions. Volatile Fluorocarbon Isocyanates Can Be Conveniently Prepared From The Corresponding Amides By Reaction With Agf2,And Fluorocarbon Azoalkanes,Rfcf2N = Ncf2Rf,From Nitriles By Use Of The Same Reagent. Similarity Of The Isocyanate Synthesis To The Hofman And Curtius Reactions Is Discussed.
DOI:10.1021/ja01502A027

专利信息

专利号:WO-2013132505-A1
优先权日:2012-03-09
标题 :Improved process for preparation of octreotide by solution phase peptide synthesis
发明人：KOTA SATYANARAYANA; TALLAPANENI VENKATESWARLU; ADIBHATLA KALI SATYA BHUJANGA RAO; NANNAPANENI VENKAIAH CHOWDARY
权利人:NATCO PHARMA LTD; KOTA SATYANARAYANA; TALLAPANENI VENKATESWARLU; ADIBHATLA KALI SATYA BHUJANGA RAO; NANNAPANENI VENKAIAH CHOWDARY
摘要:The present invention relates to a novel processes for commercial production of pharmaceutical grade octreotide using classical solution phase peptide synthesis in high yield and purity and using inexpensive amino acid derivatives. Thus the protected octapeptide alcohol Boc -D- Phe - Cys (Trt)-Phe -D - Trp - Lys (Boc) - Thr - Cys (Trt) - Thr - OL is prepared by condensation of hexapeptide acid Boc -D - Phe - Cys (Trt)-Phe -D - Trp - Lys (Boc) - Thr - OH with dipeptide alcohol H- Cys (Trt) - Thr - OL. The hexapeptide Boc -D- Phe - Cys (Trt)-Phe -D - Trp - Lys (Boc) - Thr - OMe is prepared by condensing Boc - D - Phe - Cys (Trt) - OH with tetrapeptide H-Phe -D - Trp - Lys (Boc) - Thr - OMe followed by hydrolysis. The linear octapeptide alcohol is treated with cocktail mixture TFA /water/ TIS (9.0:0.5:0.25), in one step removes the Trt and Boc groups, followed by oxidation with hydrogen peroxide to affords octreotide.

专利号:CN-102686601-A
优先权日:2009-11-16
标 题 :Synthesis of Ac-Arg-cyclo(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2

专利号:WO-2011060355-A1
优先权日:2009-11-16
标题 :Process for the synthesis of ac-arg-cyclo(cys-d-ala-his-d-phe-arg-trp-cys)-nh2

专利号:JP-2013510881-A
优先权日:2009-11-16
标题 :Method for the synthesis of Ac-Arg-cyclo (Cys-D-Ala-His-D-Phe-Arg-Trp-Cys) -NH2