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CAS号501-00-8 3-氟苯乙腈 | CAS号456-41-7 3-氟苄溴 | CAS号456-88-2 3-氟-DL-苯丙氨酸 | CAS号404-96-6 Benzenepropanam... | CAS号458-45-7 3-氟肉桂酸 | CAS号587-41-7 α-benzoylamino-... | CAS号214045-84-8 6-氟-3,4-二氢-1(2H...

3-氟苯乙醛置于l-Alanine Dehydrogenase,ω-Transaminase,氨体系中,化学反应生成 3-氟苯乙胺
参考文献:生物催化形式的反马尔科夫尼科夫加氢胺化和芳烃的水合
标题:生物催化形式的反马尔科夫尼科夫加氢胺化和芳烃的水合
摘要:基于涉及酶级联反应的两个概念,实现了生物催化抗马尔科夫尼科夫烯烃的水合和水合反应:环氧化-异构化-水合胺化和环氧化-异构化-水合还原.的大肠杆菌菌株共表达苯乙烯单加氧酶(smo),苯乙烯氧化物异构酶(soi),ω转氨酶(cvta)和丙氨酸脱氢酶(aladh)催化的12个的芳烯烃加氢胺化,得到高的转化率相应的有价值末端胺(许多>=86%)和专有的抗马尔可夫尼科夫选择性(> 99:1).另一株大肠杆菌共表达smo,Soi和苯乙醛还原酶(par)的菌株以高转化率(许多>=80%)和非常高的抗马尔科夫尼科夫选择性(> 99:1)催化12种芳基烯烃水合为相应的有用末端醇.重要的是,发现soi可将手性环氧化物立体选择性异构化为手性醛,从而为酶法环氧化物重排提供了一些见识.利用这种立体选择性重排,高对映选择性的抗马尔科夫尼科夫水合和水合反应可将α-甲基苯乙烯以84-81%的转化率(97-92%ee)转化为相应的(S)-胺和(S)-醇.,
DOI:10.1021/acscatal.7B01464

专利信息

专利号:WO-0140193-A1
优先权日:1999-12-03
标题:Method for the synthesis of pyrazolines
发明人：BOLDI ARMEN M
权利人:CHEMRX ADVANCED TECHNOLOGIES I; BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula (I). Also claimed are novel intermediates and their methods of synthesis.

专利号:US-2002103381-A1
优先权日:2000-11-30
标 题 :Method for the synthesis of pyrazolines
发明人：BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula I: n n n Also claimed are novel intermediates and their methods of synthesis.

专利号:US-9758507-B2
优先权日:2010-07-01
标 题:Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors
发明人：SILVERMAN RICHARD B; XUE FENGTIAN
权利人:UNIV NORTHWESTERN
摘要:A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-6933303-B2
优先权日:2001-10-19
标 题:Heteroaryl-fused nitrogen heterocycles as therapeutic agents
发明人：MJALLI ADNAN M M; ANDREWS ROBERT C; XIE RONGYUAN; YARRAGUNTA RAVINDRA R; REN TAN
权利人:TRANSTECH PHARMA INC
摘要:This invention provides compounds which are useful as inhibitors of protein tyrosine phosphatases (PTPases). As inhibitors of PTPases, the compounds of the invention are useful for the management, treatment, control and adjunct treatment of diseases mediated by PTPase activity. Such diseases include type I diabetes, type II diabetes, immune dysfunction, AIDS, autoimmunity, glucose intolerance, obesity, cancer, psoriasis, allergic diseases, infectious diseases, inflammatory diseases, diseases involving the modulated synthesis of growth hormone or the modulated synthesis of growth factors or cytokines which affect the production of growth hormone, or Alzheimer's disease.

专利号:US-8273403-B2
优先权日:2002-05-10
标题 :Generation of surface coating diversity
发明人：BARDEN MICHAEL C; KAMBOURIS PETER A
权利人:BARDEN MICHAEL C; KAMBOURIS PETER A; BIO LAYER PTY LTD
摘要:This invention relates to a surface discovery system and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. The system is built upon a synthon which comprises at least three elements: a chemical backbone coating on the solid substrate that comprises a copolymer (B) of at least one passive constituent (P) and at least one active constituent (A); a spacer unit (S) separating the backbone from a functional group; and a functional group (F). The methods comprise the following steps: 1) selecting a plurality of synthons so that each synthon has at least two points of diversity selected from P, A, S and F; 2) applying copolymer B onto a substrate; and 3) attaching a combination of S and F to constituent A of copolymer B. Steps 2) and 3) are performed such that different synthons are generated on localized regions of the substrate.