CAS: 40012-14-4; 6-Hydrazinyl-1,3-Dimethylpyrimidine-2,4(1H,3H)-Dione

专利信息

专利号:US-4093812-A
优先权日:1975-03-25
标 题:(Nitrofuryl)pyrazoles, their synthesis and use, and compositions containing them
发明人：RAINER GEORG
权利人:BYK GULDEN LOMBERG CHEM FAB
摘要:3-(5-Nitro-2-furyl)pyrazoles unsubstituted in the 5-position and 5-(5-nitro-2-furyl)pyrazoles unsubstituted in the 3-position are antimicrobials and disinfectants. The compounds are structurally represented by one of the formulae: ##STR1## wherein A is --CHO, --CN, --COOH, a protected or derived aldehyde group or a protected or derived carboxylic acid group; n B is 5-nitro-2-furyl; n R 1 is --H, substituted or unsubstituted hydrocarbyl (saturated or unsaturated; acyclic, alicyclic or aromatic; or araliphatic); substituted or unsubstituted (cycloaliphatic or aromatic) heterocyclic or acyl (carboxylic or carbonic acid); n R 2 is --H; and n n is a positive whole number of at most 2.

专利号:US-8623880-B2
优先权日:2009-03-23
标 题 :Fused pyrimidine-dione derivatives as TRPA1 modulators
发明人：CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; PATIL NISHA PARAG; KADAM ASHOK BHAUSAHEB; DESHMUKH VISHAL GOVINDRAO; DHONE SACHIN VASANTRAO; CHIKHALE RAJENDRA PRAKASH; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL
权利人:CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; PATIL NISHA PARAG; KADAM ASHOK BHAUSAHEB; DESHMUKH VISHAL GOVINDRAO; DHONE SACHIN VASANTRAO; CHIKHALE RAJENDRA PRAKASH; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL; GLENMARK PHARMACEUTICALS SA
摘要:The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

专利号:US-9000159-B2
优先权日:2009-03-23
标 题 :Fused pyrimidine-dione derivatives as TRPA1 modulators
发明人：CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; PATIL NISHA PARAG; KADAM ASHOK BHAUSAHEB; DESHMUKH VISHAL GOVINDRAO; DHONE SACHIN VASANTRAO; CHIKHALE RAJENDRA PRAKASH; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL
权利人:GLENMARK PHARMACEUTICALS SA; GLENMARK PHARMACEUTICALS SA
摘要:The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.