CAS: 38696-20-7; 5-Bromo-2-Phenylpyrimidine

该化合物是一种溴化的火利米汀衍生物,其基质为2级替代苯基.该环环化合物是有机合成,特别是制药和农用化学研究的多用途中间体.其溴性能允许通过交叉反应(如Suzuki或Buchwald-Hartwig)进一步发挥作用,从而能够构建复杂的分子结构.苯丙胺核心有助于其在医药化学中的用途,它可以作为生物活性化合物的食肉动物.该化合物的界定明确再活性和稳定性使其适合于用于受控合成转化. 它通常在标准实验室条件下处理,其纯性和一致性是可靠性能的关键属性.

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1260770-85-1 1086381-99-8 7431-45-0

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上下游产品

CAS号183438-24-6 5-溴-2-碘嘧啶 | CAS号98-80-6 苯硼酸 | CAS号32779-37-6 2,5-二溴嘧啶 | CAS号114078-88-5 5-溴-1,2,3-三嗪 | CAS号618-39-3 苯甲脒 | CAS号179260-95-8 5-溴-2-苯基嘧啶-4-羧酸 | CAS号130161-46-5 2-苯基嘧啶-5-甲醛 | CAS号66739-85-3 2-phenylpyrimid...

合成工艺路线路线简述

    📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成 5-溴-2-苯基嘧啶
    参考文献:Kunckell; Zumbusch,Chemische Berichte,1902,Vol. 35,P. 3168
    标题:Kunckell; Zumbusch,Chemische Berichte,1902,Vol. 35,P. 3168

    海关参考信息

    专利信息


    专利号:WO-2024185814-A1
    优先权日:2023-03-06
    标题:Method for producing aryl compound containing tritylsulfanyl group
    发明人：OKAZOE TAKASHI; NOZAKI KYOKO; GATZENMEIER Tim; LIU YUE
    权利人:AGC INC; UNIV TOKYO
    摘要:The present invention provides: a substrate for achieving the highly efficient synthesis of an aryl compound containing a tritylsulfanyl group; a method for producing a compound containing an SF 5 group using the substrate; and others. The present invention is a method for producing an aryl compound containing a tritylsulfanyl group, the method comprising thiotritylating a halogenated aryl compound represented by general formula (1) [wherein A 1 represents an aryl group that may have a substituent or a heteroaryl group that may have a substituent; and X represents a halogen atom] using [(triphenylmethyl)sulfanyl]potassium or [(triphenylmethyl)sulfanyl]sodium to produce an aryl compound containing a tritylsulfanyl group, the aryl compound being represented by general formula (2) [wherein A 1 is the same as A 1 in general formula (1); and Ph represents a phenyl group].

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    主要参考文献

    参考标题:Synthesis Of Enantiopure Unnatural Amino Acids By Metallaphotoredox Catalysis
    作者:Tomer M. Faraggi,Caroline Rouget-Virbel,Juan A. Rincón,Mario Barberis,Carlos Mateos,Susana García-Cerrada,Javier Agejas,Oscar De Frutos,David W. C. Macmillan |发布日期:2021.8.20
    摘要:Wide Array Of Optically Pure Unnatural Amino Acids. This Method Utilizes A Photocatalytic Cross-Electrophile Coupling Between A Bromoalkyl Intermediate And A Diverse Set Of Aryl Halides To Produce Artificial Analogues Of Phenylalanine, Tryptophan, And Histidine. The Reaction Is Tolerant Of A Broad Range Of Functionalities And Can Be Leveraged Toward The Scalable Synthesis Of Valuable Pharmaceutical Scaffolds

    合成参考文献


    摘要:Campagne, J. M.; Leclerc, E., Science of Synthesis Knowledge Updates, (2020) 2, 170.
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