CAS: 306-67-2; N1,N1'-(Butane-1,4-Diyl)Bis(Propane-1,3-Diamine) Tetrahydrochloride

该化合物是生物化学和分子生物学研究中广泛使用的一种聚胺化合物,作为精子的四氢氯化盐,它提供了水溶液中的强化溶解性,便利了其用于各种实验用途,该化合物在核酸稳定,蛋白结晶化和细胞培养研究方面发挥着关键作用,因为它有能力与具有负电荷的生物分子进行互动,其高纯度和稳定性使它适合于敏感分析,包括涉及DNA凝聚和酶调节的实验.

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CAS号71-44-3 精胺

合成工艺路线路线简述

  • 合成目标产物 Spermine Tetrahydrochloride 主要起始原料 Spermine
  • (文献来源)合成步骤主要原料 Spermine
精胺 在 二氯甲烷体系中,反应 0.05H,以61%的收率获得spermine TetrahydroChloride
参考文献:Spermine Adducts Of Metal Alkoxides
标题:Spermine Adducts Of Metal Alkoxides
摘要:Reaction Of Spermine With M(Oipr)(4) (M = Ti,Zr) In Toluene Solution Results In The Formation Of Crystalline Coordination Polymers [M-2(Oipr)(8)(C10H26N4)](A). In These Compounds,Only The Terminal Primary Amino Groups Are Coordinated To The Metal Centers. The Adducts Are Stabilized By Intramolecular Hydrogen Bonds. Nmr Spectroscopy Indicates That Only The Adduct With Zr(Oipr)(4) Is Stable In Benzene Solution,Whereas It Dissoiates In The Case Of Ti(Oipr)(4). When Dichloromethane Was Used As The Solvent,Spermine DihydroChloride Crystallized From The Solution.
Doi:10.1007/S00706-012-0862-X

海关参考信息

专利信息


专利号:US-8354524-B2
优先权日:2001-03-22
标 题:Synthesis of selenium-derivatized nucleosides, nucleotides, phosphoramidites, triphosphates and nucleic acids
发明人:HUANG ZHEN
权利人:UNIV GEORGIA STATE RES FOUND; HUANG ZHEN
摘要:The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonucleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.

专利号:US-2023219881-A1
优先权日:2022-01-11
标题 :Synthesis of Spermidine, Spermine, and Free Bases Thereof
发明人:TITLOW MATTHEW; GU XINGLONG
权利人:COMPOUND SOLUTIONS INC; SHAOXING KING YEAR BIOCHEMICAL CO LTD
摘要:A simplified synthetic process for production of spermine and spermidine are presented that can provide spermine and spermidine in free base or salt form. Advantageously, the synthetic procedure is safe, simple, and environmentally friendly, while at the same time also being cost-effective.

专利号:US-2003055016-A1
优先权日:2001-03-22
标 题:Synthesis of selenium-derivatized nucleosides, nucleotides, phosphoramidites, triphosphates and nucleic acids

专利号:US-2012065387-A1
优先权日:2001-03-22
标题:Synthesis of selenium-derivatized nucleosides, nucleotides, phosphoramidites, triphosphates and nucleic acids

专利号:US-7982030-B2
优先权日:2001-03-22
标 题 :Synthesis of selenium-derivatized nucleosides, nucleotides, phosphoramidites, triphosphates and nucleic acids

专利号:US-7592446-B2
优先权日:2001-03-22
标题:Synthesis of selenium-derivatized nucleosides, nucleotides, phosphoramidites, triphosphates and nucleic acids
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主要参考文献


1: Cervelli M, Leonetti A, Duranti G, Sabatini S, Ceci R, Mariottini P. Skeletal Muscle Pathophysiology: The Emerging Role of Spermine Oxidase and Spermidine. Med Sci (Basel). 2018 Feb 14;6(1). pii: E14. doi: 10.3390/medsci6010014. Review.
2: Sindhu KK. Uremic toxins: some thoughts on acrolein and spermine. Ren Fail. 2016 Nov;38(10):1755-1758. doi: 10.1080/0886022X.2016.1229990. Epub 2016 Oct 19. Review. doi: 10.1134/S0006297913130051. Review. doi: 10.1002/iub.1237. Epub 2014 Jan 6. Review. doi: 10.1007/s00726-013-1591-0. Epub 2013 Sep 17. Review. doi: 10.1007/s00726-013-1579-9. Epub 2013 Sep 3. Review. doi: 10.1007/s00239-013-9570-3. Epub 2013 Jul 5. Review. doi: 10.1016/j.mehy.2012.07.010. Epub 2012 Aug 6. Review. doi: 10.4161/gmic.19345. Review.
10: Cervelli M, Amendola R, Polticelli F, Mariottini P. Spermine oxidase: ten years after. Amino Acids. 2012 Feb;42(2-3):441-50. doi: 10.1007/s00726-011-1014-z. Epub 2011 Aug 2. Review. doi: 10.1007/s00726-009-0399-4. Epub 2009 Dec 3. Review. doi: 10.1007/s00018-009-0165-5. Epub 2009 Oct 27. Review.

合成参考文献


参考文献:10.1007/bf00177441
摘要:Vavruch L, Nordenskjöld B, Carstensen J, Eneström S. DNA ploidy and S-phase in recurrent astrocytomas: a retrospective study by flow cytometry of deparaffinized specimens. J Neurooncol. 1996 Oct;30(1):37–45. doi: 10.1007/bf00177441.
参考文献:10.1007/bf00143389
摘要:Schenkel E, Dubois JG, Helson-Cambier M, Hanocq M. Cytotoxicity of polyamines to Amoeba proteus: role of polyamine oxidase. Cell Biol Toxicol. 1996 Feb;12(1):1–9. doi: 10.1007/bf00143389.
参考文献:10.1186/1472-6750-11-54
摘要:Lutz KA, Wang W, Zdepski A, Michael TP. Isolation and analysis of high quality nuclear DNA with reduced organellar DNA for plant genome sequencing and resequencing. BMC Biotechnol. 2011 May 20;11():54.
参考文献:10.1007/s13197-012-0621-3
摘要:Chong CY, Abu Bakar F, Rahman RA, Bakar J, Zaman MZ. Biogenic amines, amino acids and microflora changes in Indian mackerel (Rastrellinger kanagurta) stored at ambient (25–29 °C) and ice temperature (0 °C). Journal of Food Science and Technology. 2012 Feb 02;51(6):1118–25. doi: 10.1007/s13197-012-0621-3.
参考文献:10.1007/bf02370172
摘要:Shearer WT, Ulrich RG, McClure JE, Green CG, Gilliam EB, Das C, Langone JJ. Cyclic AMP and theophylline enhance DNA synthesis in L cells stimulated with anti-actin IgG and [(IgG)2protein A]2 complex by recruiting cells into S-phase. Molecular and Cellular Biochemistry. 1985 Jul;67(2):135–44. doi: 10.1007/bf02370172.
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