CAS: 28910-99-8; 1-Methyl-8-Nitro-6-Phenyl-4H-[1,2,4]Triazolo[4,3-A][1,4]Benzodiazepine

📜7-Nitro-1,3-Dihydro-5-Phenyl-2H-1,4-Benzodiazepine-2-Thione,正丁醇 以 水 用作溶剂,化学反应生成1-甲基-8-硝基-6-苯基-4H-均三唑并[4,3-A][1,4]苯并二氮杂卓
参考文献:6-Phenyl-4H-S-Triazolo[4,3-A][1,4]Benzodiazepines
标题:6-Phenyl-4H-S-Triazolo[4,3-A][1,4]Benzodiazepines
摘要:6-苯基-4H-S-三唑并[4,3-A][1,4]苯二氮杂环己烷的化学式(iv):##spc1##其中r选自由氢,1至3个碳原子的烷基,苯基,苄基和-Coor'的群,其中r'是1至4个碳原子的烷基;其中r.Sub.1选自由氢和1至3个碳原子的烷基;其中r.Sub.2,R.Sub.3,R.Sub.4和r.Sub.5选自由氢,1至3个碳原子的烷基,卤素,硝基,氰基,三氟甲基和烷氧基,烷硫基,烷基亚硫基,烷基磺基,烷酰胺基和二烷基胺基,其中碳链基团为1至3个碳原子,通过将化学式(i)的1,3-二氢-5-苯基-2H-1,4-苯二氮杂环己烷-2-硫酮与化学式的有机酸酰肼缩合而制备:##spc2##其中r.Sub.1,R.Sub.2,R.Sub.3,R.Sub.4和r.Sub.5如上所定义,与化学式的有机酸酰肼缩合:##equ1##其中r如上所定义.公式iv的新产品及其药理学上可接受的酸盐在哺乳动物和鸟类中作为镇静剂,安定剂和肌肉松弛剂具有用途.

专利信息

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.