CAS: 2706-50-5; Amphetamine Hydrochloride

该化合物是一种具有分子式C9H14ClN的手性有机化合物.它有一个苯乙胺主干体,在阿尔法位置上由一个甲基组替代,形成一种盐酸盐,以加强稳定性和溶解性.该复合体通常用于药物研究和有机合成,特别是在开发生物活性分子和手性中间体方面.其盐化形式确保了一致的处理和储存特性.结构改变(α-甲基化)影响其反应性和结合性,使其对研究...

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diethyl (1-phenylpropan-2-yl)phosphoramidate 21H22NOPC21H22NOP 1-methyl-2-phenylethylmagnesium bromide allylbenzene3-(α-methylphenethyl)sydnone imine 3-[(1-Methyl-2-phenyl-ethylamino)-methyl]-5-pyridin-4-yl-3H-[1,3,4]oxadiazole-2-thione; hydr°Chloride 4-methyl-N-(1-phenylpropan-2-yl)benzenesulfonamide N-(1-Methyl-2-phenylethyl)harnstoff

合成工艺路线路线简述

    📜右旋苯丙胺置于盐酸体系中,用 水,甲苯 用作溶剂,化学反应 3.0H,反应生成外消旋安非他命盐酸盐溴化物
    参考文献:α-手性胺与 D2O 的立体保留氘化
    标题:α-手性胺与 D2O 的立体保留氘化
    摘要:我们展示了使用 Ru-Bmepi (Bmepi = 1,3-(6'-Methyl-2'-Pyridylimino)Isoindolate) 配合物和 D2O 对伯胺进行直接和立体保留的氘化.高氘掺入发生在 α-碳 (70-99%).对于 α-手性胺,使用缺电子 Ru 催化剂时可完全保留立体化学.对映体纯度的保持归因于亚胺中间体与钌的高结合亲和力,以及相对于配体解离的快速 H/d 交换.
    Doi:10.1021/jacs.6B07879

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    专利信息


    专利号:US-4000197-A
    优先权日:1973-07-23
    标 题 :Asymmetric synthesis of phenylisopropylamines
    发明人:BARFKNECHT CHARLES F; NICHOLS DAVID E
    权利人:UNIV IOWA RES FOUND
    摘要:The synthesis of enantiomers of a series of methoxy- and alkyl- substituted phenylisopropylamines is described. The synthesis comprises reducing the imines, formed by the reaction of appropriate phenylacetones with either (+)- or (-)-α-methylbenzylamine, by low-pressure reduction techniques, and subsequently subjecting the optically active N-(α-phenethyl)phenylisopropylamine derivative to hydrogenolysis. The hydrogenolysis products are characterized by enantiomeric purities in the range of 96 - 99%. Yields of products are approximately 60%.

    专利号:US-2016122450-A1
    优先权日:2013-05-08
    标题:Synthesis of a substituted furan
    发明人:ZHANG YUGEN; TEONG SIEW PING; YI GUANGSHUN
    权利人:AGENCY SCIENCE TECH & RES
    摘要:The present invention provides a polymer comprising an aliphatic backbone having a plurality of aromatic rings bonded thereon, said plurality of aromatic rings comprising a first aromatic ring type that has an alkyl halide group substitution on the aromatic ring and a second aromatic ring type that has an optionally substituted ammonium halide group substitution on the aromatic ring. The present invention also provides a method for making an optionally substituted furan, the method comprising the step of subjecting a sugar to a dehydration reaction in the presence of a catalyst comprising said polymer.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:JAMA, Journal of the American Medical Association., 94(790), 1930
    参考文献:10.1007/s002130050176
    摘要:Cabib S, Castellano C. Impairments produced by amphetamine and stress on memory storage are reduced following a chronic stressful experience. Psychopharmacology (Berl). 1997 Jan;129(2):161–7. doi: 10.1007/s002130050176.
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