CAS: 2390-99-0; Chanoclavine

📜4-吲哚甲醛置于盐酸,4-二甲氨基吡啶,Palladium Diacetate,Sodium Tetrahydroborate,Sodium Periodate,四氧化锇,Lithium Aluminium Tetrahydride,水,二异丁基氢化铝,Potassium Carbonate,N-甲基吗啉氧化物,R-(+)-1,1'-联萘-2,2'-双二苯膦,三乙胺,汞,三氟乙酸,锌体系中,用 四氢呋喃,甲醇,乙醚,二氯甲烷,丙酮,乙腈 用作溶剂,化学反应 90.58H,反应生成裸麦角碱
参考文献:Synthesis Of (−)-Chanoclavine I
标题:Synthesis Of (−)-Chanoclavine I
摘要:The Total Enantioselective Synthesis Of (-)-Chanoclavine I 2 In Twelve Steps From Indole-4-Carboxaldehyde 4 Is Described The Key-Step 3--> 6 Which Involves The Formation Of The C Ring By Creation Of The C5-C10 Bond Is Catalyzed By A Chiral Palladium (0) Complexes. The Chiral Ergoline Synthon 6 Is Produced With An Excellent Diastereo-And Enantioselectivity (Up To 95%) Eel.
Doi:10.1016/0957-4166(94)80122-3

专利信息

专利号:US-3929796-A
优先权日:1974-08-02
标 题:Synthesis of penniclavine and elymoclavine
发明人：KORNFELD EDMUND C; BACH NICHOLAS J
权利人:LILLY CO ELI
摘要:Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.

专利号:US-3968112-A
优先权日:1974-08-02
标 题:Synthesis of penniclavine and elymoclavine
发明人：KORNFELD EDMUND C; BACH NICHOLAS J
权利人:LILLY CO ELI
摘要:Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.

专利号:US-3923812-A
优先权日:1974-08-02
标题:Synthesis of elymoclavine
发明人：BACH NICHOLAS J; KORNFELD EDMUND C
权利人:LILLY CO ELI
摘要:Elymoclavine is prepared by oxidation of D-6-methyl-8hydroxymethyl-10 Alpha -methoxy-8-ergolene to the corresponding D-8-aldehyde followed by reduction with an active metal in acid medium.

专利号:US-4054567-A
优先权日:1975-08-11
标 题:6-Methyl-8β-hydroxymethyl-8-γ-substituted-9-ergolene compounds
发明人：KORNFELD EDMUND C; BACH NICHOLAS J
权利人:LILLY CO ELI
摘要:Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.

专利号:CA-1051879-A
优先权日:1974-08-02
标题 :Synthesis of elymoclavine and derivatives

专利号:CA-1042423-A
优先权日:1974-08-02
标题 :Synthesis of penniclavine and derivatives