CAS: 2295-31-0; 2,4-Thiazolidinedione

相似化合物

16312-21-3 125518-48-1 37868-80-7

上下游产品

CAS号556-90-1 假硫代乙内酰脲 | CAS号79-11-8 氯乙酸 | CAS号110-89-4 六氢吡啶 | CAS号79-04-9 氯乙酰氯 | CAS号103-85-5 N-苯基硫脲 | CAS号214282-14-1 4-[2-[1-oxo-1,2... | CAS号104742-64-5 N-[4-[(2,4-diox... | CAS号1119898-47-3 5-((4-(2,3-二氢噻吩... | CAS号34301-40-1 5-[(4-硝基苯基)亚甲基]... | CAS号438190-29-5 (Z)-SMI-4A | CAS号141037-40-3 3-(2-hydroxy-3-... | CAS号92972-48-0 2,4-二氯噻唑-5-甲醛 | CAS号4175-77-3 2,4-二溴噻唑 | CAS号24044-50-6 5-[(4-羟基-3-甲氧基苯... | CAS号24044-52-8 5-[(3-硝基苯基)亚甲基]... | CAS号55359-96-1 4-氯-2,3-二氢-2-氧代...

假硫代乙内酰脲置于盐酸,水体系中,化学反应 10.0H,以77.2%的收率获得2,4-噻唑烷二酮
参考文献:(e)-5-[(1-Aryl-1 H-1,2,3-Triazol-4-Yl)亚甲基]噻唑烷-2,4-二酮的合成及抗癌活性
标题:(e)-5-[(1-Aryl-1 H-1,2,3-Triazol-4-Yl)亚甲基]噻唑烷-2,4-二酮的合成及抗癌活性
摘要:摘要通过将相应的1-芳基-1 H-1,2,3-三唑-4-甲醛与噻唑烷-2,4-二酮缩合,合成了一系列新的1,2,3-三唑基噻唑烷二酮类似物.Koh.使用mtt测定法针对四种癌细胞系:A549(肺),Ht-29(结肠),Mcf-7(乳腺癌)和a375(黑素瘤)评估了标题化合物的体外抗癌活性.大多数化合物显示出非常好的抗癌活性,但是羟基和硝基取代的衍生物显示出比其他化合物更高的活性.
Doi:10.1134/s1070428020050206

专利信息

专利号:US-11161827-B2
优先权日:2019-04-05
标 题 :Catalytic systems for stereoselective synthesis of chiral amines by enantiodivergent radical C—H amination
发明人：Zhang xiao-xiang; Lang kai
权利人:TRUSTEES BOSTON COLLEGE; THE TRUSTEES OF BOSTON COLLEGE
摘要:In one aspect, the disclosure relates to a mode of asymmetric induction in radical processes based on sequential combination of enantiodifferentiative H-atom abstraction and stereoretentive radical substitution. Also disclosed is an asymmetric system for stereoselective synthesis of strained 5-membered cyclic sulfamides via radical 1,5-C—H amination of sulfamoyl azides. The disclosed metalloradical system can control the degree and sense of asymmetric induction in the catalytic radical C—H amination in a systematic manner. The disclosed system is applicable to a broad scope of substrates with different types of C(sp 3 )—H bonds and exhibits reactivity and selectivity, providing access to both enantiomers of useful 5-membered cyclic sulfamides in a highly enantioenriched form. Also disclosed are catalysts useful in these processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:WO-2023012709-A1
优先权日:2021-08-05
标 题 :An improved process for fmoc synthesis of semaglutide
发明人：LOBO LESTER JOHN; CHANDRAKESAN MURALIDHARAN; DOSHI CHETAN; CHANADAK SHAILESH LALCHAND; YADAV NANDLAL GOPAL; MOHE NIKHIL UMESH; VISHWANATHAN KODANDARAMAN
权利人:USV PRIVATE LTD
摘要:The present invention relates to an improved process for the synthesis of glucagon-like-peptide-1 (GLP-1) and its analogs by using combination of solid and solution phase synthesis of Fmoc protected amino acids in a sequential manner, optionally incorporating Boc protected dipeptide for unnatural amino acid in the Sequence of GLP-1, cleaving GLP-1 sequence from the resin followed by purification; attaching side-chain to the desired amino acid in the solution phase to synthesize desired GLP-1 analog, purifying it to Semaglutide. Temperature gradient is applied during initial coupling of amino acids to facilitate completion of difficult coupling reactions.

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:US-6376667-B1
优先权日:1997-11-26
标 题 :Solid phase synthesis of heterocycles
发明人：CASTELHANO ARLINDO L; SHAO HUI
权利人:OSI PHARM INC
摘要:Methods and compounds for the synthesis of heterocycles, including pyrimidine-2,4-diones, are disclosed. Also disclosed are solid supports useful for solid phase synthesis, and methods for making the solid supports.

专利号:US-11912647-B2
优先权日:2020-05-22
标 题:Diversity-oriented synthesis of N,N,O-trisubstituted hydroxylamines from alcohols and amines by N—O bond formation
发明人：CRICH DAVID; HETTIKANKANAMALAGE ASIRI; HILL JARVIS
权利人:UNIV GEORGIA
摘要:In one aspect, the disclosure relates to a method for the direct synthesis of complex N,N,O-trisubstituted hydroxylamines by N—O bond formation. In another aspect, the method can successfully be employed using a wide variety of commercially available alcohols and secondary amines and enables the construction of large fragment-based libraries of trisubstituted hydroxylamines for drug discovery purposes. Also disclosed are N,N,O-trisubstituted hydroxylamines having low basicity, high stability at ambient temperatures, and an inherent lack of reactivity towards acetylating and sulfonylating enzymes that confer mutagenicity on less-substituted hydroxylamines.

专利号:US-11459549-B2
优先权日:2018-05-10
标 题:Method for biocatalytic synthesis of Sitagliptin and intermediate thereof
发明人：WU FAHAO; YANG WEN; LI GANG; SHI HONGWEI; GAO YANGZHE; LIU LILI; YUAN ZHIFA
权利人:CHINA FORTUNE WAY COMPANY; NANJING REDWOOD FINE CHEMICAL CO LTD
摘要:Provided is a method for biocatalytic synthesis of Sitagliptin and intermediates thereof, in particular, provided are compounds of Formula (I) and Formula (II), or pharmaceutically acceptable salts thereof, a polypeptide capable of catalyzing conversion of a compound of Formula (I) to a compound of Formula (II), a nucleic acid encoding the polypeptide, a vector and a cell comprising the nucleic acid. In addition, also provided are a method for producing a compound of Formula (II) and Sitagliptin by using the polypeptide and the compound of Formula (I), and a method for preparing the polypeptide.