CAS: 2164-84-3; 4,6-Diamino-5-Nitropyrimidine

相似化合物

118-70-7 49721-45-1 23120-18-5

上下游产品

CAS号118-70-7 4,5,6-三氨基嘧啶

4,6-二氯-5-硝基嘧啶置于ammonium Hydroxide体系中,化学反应 7.0H,以87%的收率获得5-硝基-4,6-二氨基嘧啶
参考文献:一种4,5,6-三氨基嘧啶的合成方法
标题:一种4,5,6-三氨基嘧啶的合成方法
摘要:本发明公开了一种4,5,6‑三氨基嘧啶的合成方法,通过5‑硝基‑4,6‑二羟基嘧啶,三氯氧磷和有机碱制得中间产物4,6‑二氯‑5‑硝基嘧啶,4,6‑二氯‑5‑硝基嘧啶和氨水制得的产物在加入乙醇,然后和水合肼,雷尼镍制得4,5,6‑三氨基嘧啶的合成方法,本发明只需3步即可得到目标物,总产率高,合成路线短,反应温和,时间短,操作简单安全,同时采用4,6‑二氯‑5‑硝基嘧啶为起始原料,由于该原料有大量商业供应,廉价易得,辅料可以回收套用,可明显降低成本,由于本发明选用了合适的原料和辅料,避免了生产过程中有毒物质对环境的污染,并且制得嘧啶收率和纯度高,具有非常好的工业化应用前景.

专利信息

专利号:US-7105666-B2
优先权日:2002-06-27
标 题:Synthesis of purine derivatives
发明人：HAMMARSTROEM LARS G J; KRAUSS NANCY ELISABTH; LABADIE SHARADA SHENVI; SMITH DAVID BERNARD; TALAMAS FRANCISCO XAVIER
权利人:ROCHE PALO ALTO LLC
摘要:The present invention provides a method for producing 2-, 6-, 8- and 9-substituted purine compounds from 4,6-dihalo-5-nitro-2-alkyl-pyrimidine compounds in solution or by solid phase techniques. The present process provides for the sequential introduction of amine substituents at the 4- and 6-positions, displacement of an alkylsulfony group at the 2-position of the pyrimidine, reduction of the nitro group and formation of the imidazole portion of the purine compound. Furthermore, the methods of the present invention are ideally suited to the preparation of a library of purine compounds.

专利号:CA-2488562-A1
优先权日:2002-06-27
标 题:Synthesis of purine derivatives

专利号:JP-2005535631-A
优先权日:2002-06-27
标题 :Synthesis of purine derivatives

专利号:US-2004034224-A1
优先权日:2002-06-27
标题:Synthesis of purine derivatives

专利号:EP-1519938-A2
优先权日:2002-06-27
标题:Synthesis of purine derivatives

专利号:WO-2004002990-A2
优先权日:2002-06-27
标题 :Synthesis of purine derivatives