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CAS号109-70-6 1-溴-3-氯丙烷 | CAS号263149-10-6 4-氯-7-羟基-6-甲氧-3-腈基喹啉 | CAS号3943-74-6 香草酸甲酯 | CAS号3535-27-1 4-异丙氧基-3-甲氧基苯甲酸甲酯 | CAS号50413-53-1 2-氨基-4-异丙氧基-5-甲... | CAS号948553-02-4 4-异丙氧基-5-甲氧基-2-... | CAS号741276-43-7 4-氯-7-异丙氧基-6-甲氧... | CAS号319492-96-1 1,4-二氢-6-甲氧基-7-... | CAS号627-30-5 3-氯-1-丙醇 | CAS号380843-75-4 伯舒替尼 | CAS号380844-49-5 7-(3-氯丙氧基)-4-[(...

香草酸甲酯置于氯化亚砜,氨,水,溴,Sodium Ethanolate,Potassium Carbonate,溶剂黄146,Sodium Hydroxide,三氯氧磷体系中,用 甲醇,乙醇,乙酸酐,二甲基亚砜,N,N-二甲基甲酰胺 用作溶剂,化学反应 31.0H,反应生成4-氯-7-(3-氯丙氧基)-3-氰基-6-甲氧基喹啉
参考文献:A New And Practical Synthesis Of Bosutinib
标题:A New And Practical Synthesis Of Bosutinib
摘要:New And Improved Synthetic Route Of Bosutinib Is Described On A Decagram Scale. An Intramolecular Cyclization Of 3-Amino-2-(2-Bromobenzoyl)-Acrylonitrile (22) In K2Co3/dmf Condition To Form The Key 3-Cyano-4-Hydroxyquinoline Intermediate (13) Is Adopted As The Key Step. Bosutinib Is Obtained In 13.7% Yield Over Ten Steps And 98.9% Purity (HPLC),Which Make It As A Process Of Cost Effective,Environmentally Friendly And Feasible For Scale-Up Operation.
Doi:10.3987/com-14-13117