CAS: 21434-91-3; 6-(3,4,5-Trimethoxybenzamido)Hexanoic Acid

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CAS号4521-61-3 3,4,5-三甲氧基苯甲酰氯 | CAS号60-32-2 6-氨基己酸

📜3,4,5-三甲氧基苯甲酰氯,6-氨基己酸置于sodium Hydroxide体系中,化学反应 2.0H,以86%的收率获得克冠酸
参考文献:四胺的合成和选择性 M-胆碱阻断活性.第二部分
标题:四胺的合成和选择性 M-胆碱阻断活性.第二部分
摘要:已证明这些物质对胆碱受体 [i] 的 M2 亚型具有选择性亲和力,并且已确定至少一种合成化合物 [xiii: Ar=ph,A=(Ch2)6,B = 1,4-C6H4(Ch2)2] 与甲胺丁胺 [at = 2-Meoc6H4,A = (Ch2)6,B = (Che)S] 相比具有更高的选择性,被认为是该类型中最有前途的制剂 [2] . 这项工作的目的是获得新的四胺 I,其中基团 B 的部分亚甲基被氧原子取代.预计这种取代将显着改变初始化合物的性质.分子极性和亲水性的增加必须改变它们的构象特性,从而改变化合物的生物活性(包括对某些亚型 M-胆碱受体的特异性).
Doi:10.1007/bf02464370

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:US-2008107598-A1
优先权日:2006-10-05
标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications

专利号:EP-2079486-A2
优先权日:2006-10-05
标题:Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:US-2013039853-A1
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:CN-101678118-A
优先权日:2006-10-05
标 题:Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications