CAS: 21401-21-8; (R)-2-(4-Hydroxyphenyl)-2-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Acetonitrile

上下游产品

amygdalin methanol 4-formylphenyl acetate 13H17NO3SiC13H17NO3Si

📜苦杏仁苷置于extracellular Enzymes From Aspergillus Niger体系中,化学反应 4.0H,反应生成紫杉氰醣苷
参考文献:黑曲霉胞外酶催化降解苦杏仁苷
标题:黑曲霉胞外酶催化降解苦杏仁苷
摘要:摘要 苦杏仁苷是一种备受争议的抗肿瘤天然产物,多年来一直被用作抗癌药物.苦杏仁苷的抗肿瘤机制和代谢一直是许多研究的焦点.然而,我们课题组此前的研究表明,苦杏仁苷本身没有抗肿瘤活性,但活性成分被确定为苦杏仁苷降解产物.为了筛选具有抗肿瘤活性的新型药物,黑曲霉的胞外酶被用于降解苦杏仁苷.在 37°催化反应的 4 小时内,苦杏仁苷迅速降解为四种产物.然后通过柱色谱法提取和纯化产物.通过HPLC色谱图,1 H NMR,13 C NMR和ms数据的比较,确定产物为扁桃腈,李子苷,苯甲醛和苯基-(3,4,5-Trihydroxy-6-Methyl-Tetrahydro-Pyran-2-Yloxy)-Acetonitrile (Ptmt),一种新型的prunasin羟基衍生物.此外,这些化合物的药理学研究表明,10 Mg/kg 的 Ptmt置于11 天内以浓度依赖性方式显着抑制 S-18 肿瘤细胞的生长.
Doi:10.1016/j.Procbio.2011.10.030

专利信息

专利号:US-7829124-B2
优先权日:2001-04-26
标题:Use of Phyllanthus constituents for treating or preventing infections caused by hepatitis B-viruses
发明人：OTT MICHAEL; MANNS MICHAEL P
权利人:OTT MICHAEL; MANNS MICHAEL P
摘要:The disclosure relates to a method of inhibiting synthesis of viral DNA in a mammal infected with a hepatitis B virus. This method includes administering at least one Phyllanthus component or substance to a mammal infected with the hepatitis B virus. It also includes inhibiting hepatitis B viral DNA synthesis in the mammal using the Phyllanthus component or substance. The disclosure also relates to a method of inhibiting viral gene expression in a mammal infected with a hepatitis B virus. This method includes administering at least one Phyllanthus component or substance to a mammal infected with the hepatitis B virus. It also includes inhibiting expression of at least one hepatitis B viral gene in the mammal using the Phyllanthus component or substance. These methods may form part of a method of preventing or treating hepatitis B infection.