CAS: 183232-66-8; 1-(2,4-Dichlorophenyl)-5-(4-Iodophenyl)-4-Methyl-N-Piperidin-1-Ylpyrazole-3-Carboxamide

上下游产品

1-(2,4-dichlorophenyl)-5-(4-bromophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide H-pyrazole-3-carboxylic acid piperidin-1-ylamide5-(4-amino-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide 2,4-dichlorophenyl hydrazine hydr°Chloride 1-phenyl-propan-1-one4-(4-(1-(2,4-dichlorophenyl)-4-methyl-3-(piperidin-1-ylcarbamoyl)-1H-pyrazol-5-yl)phenyl)but-3-yn-1-yl nitrate 1-(2,4-dichlorophenyl)-5-(4-(4-iodobut-1-ynyl)phenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

📜5-(4-Bromophenyl)-1-(2,4-Dichlorophenyl)-4-Methyl-1H-Pyrazole-3-Carboxylic Acid置于四(三苯基膦)钯,氯化亚砜,Chloroamine-T,六正丁基二锡,溶剂黄146,三乙胺,Sodium Iodide体系中,用 二氯甲烷,甲苯 用作溶剂,化学反应 35.0H,反应生成1-(2,4-二氯苯基)-5-(4-碘苯基)-4-甲基-N-1-哌啶基-1H-吡唑-3-羧胺
参考文献:Preparation Of Iodine-123 Labeled Am251: A Potential Spect Radioligand For The Brain Cannabinoid Cb1 Receptor
标题:Preparation Of Iodine-123 Labeled Am251: A Potential Spect Radioligand For The Brain Cannabinoid Cb1 Receptor
摘要:
Doi:10.1002/(Sici)1099-1344(199610)38:10<875::Aid-Jlcr908>3.0.Co;2-G

专利信息

专利号:US-2022370650-A1
优先权日:2021-03-26
标 题 :Formulations and kits for the diagnostic evaluation of infectious diseases and methods thereof
发明人：BRYANT JR JERRY L
权利人:VYRIPHARM ENTPR INC
摘要:Kits for the preparation, synthesis, and delivery of compositions comprising a conjugate of a nucleoside analog, a chelator, and a label for use as imaging and therapeutic agents. The kits, as well as methods for their use, may be used in diagnosing, treating, or monitoring the progression of infectious diseases and/or symptoms or complications resulting from infection.

专利号:WO-2008084057-A1
优先权日:2007-01-10
标题:Compounds with a combination of cannabinoid-cb1 antagonism and serotonin reuptake inhibition
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G
权利人:SOLVAY PHARM BV; LANGE JOSEPHUS H M; KRUSE CORNELIS G
摘要:This invention relates to compounds with a combination of cannabinoid-CB1antagonism and serotonin reuptake inhibition to pharmaceutical compositions containing these compounds, to methods for preparing the compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing compositions. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in psychosis, anxiety, depression, attention deficits, cognitive disorders, obesity, drug dependence, Parkinson's disease, Alzheimer's disease, pain disorders, neuropathic pain disorders and sexual disorders. In particular the invention relates to compoundsof the general formula (I): wherein the symbols have the meanings given in the specification.

专利号:US-8138174-B2
优先权日:2007-01-10
标 题:Compounds with a combination of cannabinoid CB1 antagonism and serotonin reuptake inhibition
发明人：LANGE JOSEPHUS H M; KRUSE CORNELIS G
权利人:LANGE JOSEPHUS H M; KRUSE CORNELIS G; SOLVAY PHARM BV
摘要:Compounds with a combination of cannabinoid CB 1 antagonism and serotonin reuptake inhibition, pharmaceutical compositions containing these compounds, methods for preparing these compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing these compositions are disclosed. Uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in psychosis, anxiety, depression, attention deficits, cognitive disorders, obesity, drug dependence, Parkinson's disease, Alzheimer's disease, pain disorders, neuropathic pain disorders and sexual disorders are disclosed. n In at least one embodiment, the invention relates to compounds of the general formula (1): n nwherein the substitutents have the definitions given in the specification.

专利号:US-7754188-B2
优先权日:2003-06-30
标 题:Radiolabeled cannabinoid-1 receptor modulators
发明人：BURNS H DONALD; CHEN ALEX M; GIBSON RAYMOND E; GOULET MARK T; HAGMANN WILLIAM K; HAMILL TERENCE G; JEWELL JAMES P; LIN LINUS S; LIU PING; PERESYPKIN ANDREY V
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to particular radiolabeled Cannabinoid-1 (CB1) receptor modulators, and methods of using these modulators for labeling and diagnostic imaging of Cannabinoid-1 receptors in mammals, particularly humans. In addition, intermediates useful for the synthesis of the radiolabeled Cannabinoid-1 receptor modulators are also disclosed, as well as the processes for synthesizing the radiolabeled Cannabinoid-1 receptor modulators. Still further, formulations of the radiolabeled Cannabinoid-1 receptor compounds are described.

专利号:US-2024109830-A1
优先权日:2020-07-10
标题:Cannabis extracts and uses thereof
发明人：LINCIANO PASQUALE; CITTI CINZIA; RUSSO FABIANA; LUONGO LIVIO; IANNOTTA MONICA; BELARDO CARMELA; MAIONE SABATINO; VANDELLI MARIA ANGELA; FORNI FLAVIO; GIGLI GIUSEPPE; LAGANÃ? ALDO; CAPRIOTTI ANNA LAURA; MONTONE CARMELA MARIA; CANNAZZA GIUSEPPE
权利人:CONSIGLIO NAZIONALE RICERCHE; UNIV DEGLI STUDI DI MODENA E REGGIO EMILIA; SAPIENZA UNIV DI ROMA
摘要:The present disclosure concerns a group of cannabinoid compounds defined by formulas (I) to (IV), wherein R1 is —H or —COOH, for the first time isolated and fully characterized in structure, absolute stereochemistry by the present applicant. Methods of isolation, characterization, stereoselective synthesis, biological activity, pharmaceutical composition and therapeutic applications of the present compounds as modulators of the cannabinoid CB1 receptor are also object of the disclosure.