CAS: 174484-41-4; Tipranavir

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CAS号174485-72-4 5-三氟甲基吡啶-2-磺酰氯 | CAS号174485-90-6 (R)-3-((R)-1-(3... | CAS号33698-85-0 (E)-1-Chloro-2-... | CAS号174590-40-0 (4R)-3-[(3S)-3-... | CAS号188559-25-3 [R-(R*,R*)]-3-[... | CAS号188559-10-6 (4R)-3-[(2S,3S)... | CAS号188559-22-0 (2S,5R)-2-[(1S)... | CAS号188559-05-9 [R-(E)]-3-(1-Ox... | CAS号29898-25-7 1-苯基-3-己酮 | CAS号99-61-6 间硝基苯甲醛

📜(E)-Pent-2-Enoyl Chloride置于palladium On Activated Charcoal 吡啶,正丁基锂,2,3-二巯基丁二酸,Oxonium,Potassium Tert-Butylate,氢气,Sodium Carbonate,Copper(I) Bromide体系中,用 四氢呋喃,甲醇,二氯甲烷,乙酸乙酯 用作溶剂,化学反应 1.0H,反应生成替拉那韦
参考文献:Asymmetric Syntheses And Absolute Stereochemistry Of 5,6-Dihydro-α-Pyrones,A New Class Of Potent Hiv Protease Inhibitors
标题:Asymmetric Syntheses And Absolute Stereochemistry Of 5,6-Dihydro-α-Pyrones,A New Class Of Potent Hiv Protease Inhibitors
摘要:
Doi:10.1021/ja963434W

专利信息

专利号:US-7002017-B2
优先权日:2003-03-24
标题 :Enantioselective hydrogenation of intermediates in the synthesis of tipranavir
发明人：KLINGLER FRANZ DIETRICH; STEIGERWALD MICHAEL; EHLENZ RICHARD
权利人:BOEHRINGER INGELHEIM INT
摘要:The invention relates to a process for preparing the compounds of general formula I n nby enantioselective hydrogenation of the compounds of formula II n nin the presence of special hydrogenation catalysts. The invention is characterised by high enantioselectivity, providing easy access to a category of important pharmaceutical compositions, i.e. intermediates for the synthesis of tipranavir.

专利号:US-8987493-B2
优先权日:2010-05-20
标题 :Process for synthesis of silane dipeptide analogs
发明人：SIEBURTH SCOTT MCNEILL; BO YINGJIAN
权利人:SIEBURTH SCOTT MCNEILL; BO YINGJIAN; Temple University—Of the Commonwealth System of Higher Education
摘要:The invention provides a method of preparing silane dipeptide analogs, comprising the steps of treating a solution of a substituted 1,2-oxasilolane with lithium metal to form a solution of the dilithium salt of a substituted 3-hydroxypropylsilanol, and reacting the solution of the dilithium salt of the substituted 3-hydroxypropylsilanol with a substituted enamine.

专利号:US-2010261876-A1
优先权日:2007-09-25
标 题:Novel methods of synthesis for therapeutic antiviral peptides
发明人：BRAY BRIAN L; JOHNSTON BARBARA E; SCHNEIDER STEPHEN E; TVERMOES NICOLAI A; ZHANG HUYI; FRIEDRICH PAUL E
权利人:BRAY BRIAN L; JOHNSTON BARBARA E; SCHNEIDER STEPHEN E; TVERMOES NICOLAI A; ZHANG HUYI; FRIEDRICH PAUL E
摘要:Provided herein are methods for synthesis of peptides. In particular, provided herein are methods of synthesis for therapeutic antiviral peptides.

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-2016185745-A1
优先权日:2013-08-07
标题:Analogs of vinaxanthone and xanthofulvin, methods of synthesis, and methods of treatments thereof
发明人：SIEGEL DIONICIO; CHIN MATTHEW; ELIASEN ANDERS; AXELROD ABRAM
权利人:UNIV TEXAS
摘要:The present invention relates generally to methods of synthesis of vinaxanthone and xanthofulvin, novel analogs, and methods of use thereof.

专利号:US-2004110957-A1
优先权日:2002-12-05
标 题 :Process for the synthesis of an antiviral compound
发明人：WILKEN JOERG; NERENZ FRANK; KANSCHIK-CONRADSEN ANDREAS
权利人:HONEYWELL INT INC
摘要:In a process comprising synthesizing pyranes including [R—(R*,R*)]-N-[3-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide the present invention comprises the improvements comprising: (a) providing a racemic mixture of 3-hydroxy-3-(2-phenylethyl)-hexanoate ethyl acetate by reacting said 1-phenyl-hexan-3-one with ethylbromoacetate under Reformatsky conditions; and (b) separating (R)-3-hydroxy-3-(2-phenylethyl)-hexanoic acid in enantiomeric excess by saponification and reverse resolution of the racemate of step (a) to produce a resolved product. In addition, the present invention comprises a reverse resolution process for separating an enantiomer from a mixture of enantiomers.