CAS: 139954-00-0; (3S,5R,8R,9R,10S,14S)-3,17-Dihydroxy-4,4,8,10,14-Pentamethyl-2,3,4,5,6,7,8,9,10,14-Decahydro-1H-Cyclopenta[a]Phenanthrene-15,16-Dione
- 英文名称(3S,5R,8R,9R,10S,14S)-3,17-Dihydroxy-4,4,8,10,14-Pentamethyl-2,3,4,5,6,7,8,9,10,14-Decahydro-1H-Cyclopenta[a]Phenanthrene-15,16-Dione
- 中文名称芍药二酮
- IUPAC名称(3S,5R,8R,9R,10S,14S)-3,17-dihydroxy-4,4,8,10,14-pentamethyl-2,3,4,5,6,7,8,9,10,14-decahydro-1H-cyclopenta[a]phenanthrene-15,16-dione
- 其它别名Palbinone; (3Beta,5Alpha)-3,17-Dihydroxy-4,4,8,14-Tetramethyl-18-Norandrosta-11,13(17)-Diene-15,16-Dione; 18-Norandrosta-11,13(17)-Diene-15,16-Dione, 3,17-Dihydroxy-4,4,8,14-Tetramethyl-, (3β,5α)-
- CAS编号139954-00-0
- FDA UNII编号:TXG6F287LT
- 分子式:C22H30O4分子量:358.48
- 产品CID: 618160
- 产品分类天然产物 → 萜类
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2901241000-1,3-丁二烯
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主要参考文献
1: Shi Q, Wang J, Cheng Y, Dong X, Zhang M, Pei C. Palbinone alleviates diabetic retinopathy in STZ-induced rats by inhibiting NLRP3 inflammatory activity. J Biochem Mol Toxicol. 2020 Jul;34(7):e22489. doi: 10.1002/jbt.22489. Epub 2020 Mar 22. 28(2):308-11. doi: 10.1002/ptr.4993. Epub 2013 Apr 18. potent inhibitory activity on 3 alpha- hydroxysteroid dehydrogenase. Chem Pharm Bull (Tokyo). 1993 Mar;41(3):487-90. doi: 10.1248/cpb.41.487. 19(19):5556-9. doi: 10.1016/j.bmcl.2009.08.048. Epub 2009 Aug 15.
11:581984. doi: 10.3389/fphar.2020.581984.
6: Zhang JF, Li YC, Song YQ, Xia GY, Xia H, Wang YN, Tian GH, Ge GB, Lin S. Paeonone A, a novel nonanortriterpenoid from the roots of Paeonia lactiflora. Bioorg Chem. 2021 May;110:104783. doi: 10.1016/j.bioorg.2021.104783. Epub 2021 Mar 2.
合成参考文献
参考文献:10.1002/ptr.2650090515
摘要:Kadota S, Basnet P, Terashima S, Li J, Namba T, Kageyu A. Palbinone, a novel terpenoid from Paeonia albiflora: A potent inhibitory activity on human monocyte interleukin‐1β. Phytotherapy Research. 1995 Aug;9(5):379–81. doi: 10.1002/ptr.2650090515.
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